Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Michael Mareš"'
Autor:
Jakub Benýšek, Michal Buša, Petra Rubešová, Jindřich Fanfrlík, Martin Lepšík, Jiří Brynda, Zuzana Matoušková, Ulrike Bartz, Martin Horn, Michael Gütschow, Michael Mareš
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 515-526 (2022)
Cathepsin K (CatK) is a target for the treatment of osteoporosis, arthritis, and bone metastasis. Peptidomimetics with a cyanohydrazide warhead represent a new class of highly potent CatK inhibitors; however, their binding mechanism is unknown. We in
Externí odkaz:
https://doaj.org/article/c51df7b09c7a427fa4eefb8b01b73746
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background The blood flukes of genus Schistosoma are the causative agent of schistosomiasis, a parasitic disease that infects more than 200 million people worldwide. Proteases of schistosomes are involved in critical steps of host–parasite
Externí odkaz:
https://doaj.org/article/a18937be7287464f84ee8c4272801743
Autor:
Adrian Leontovyč, Lenka Ulrychová, Anthony J O'Donoghue, Jiří Vondrášek, Lucie Marešová, Martin Hubálek, Pavla Fajtová, Marta Chanová, Zhenze Jiang, Charles S Craik, Conor R Caffrey, Michael Mareš, Jan Dvořák, Martin Horn
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006446 (2018)
BACKGROUND:Serine proteases are important virulence factors for many pathogens. Recently, we discovered a group of trypsin-like serine proteases with domain organization unique to flatworm parasites and containing a thrombospondin type 1 repeat (TSR-
Externí odkaz:
https://doaj.org/article/fd9a30c7310c4f6b87532160c1ad348f
Autor:
Lenka Ulrychová, Martin Horn, Carina Lemke, Michal Buša, Michael Gütschow, Dominik Brajtenbach, Jakub Benýšek, Christian Breuer, Katharina F. Kubatzky, Annika Illies, Adéla Jílková, Ulrike Bartz, Michael Mareš
Publikováno v:
Journal of Medicinal Chemistry. 64:13793-13806
The cysteine protease cathepsin K is a target for the treatment of diseases associated with high bone turnover. Cathepsin K is mainly expressed in osteoclasts and responsible for the destruction of the proteinaceous components of the bone matrix. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec972a79fa3c0ad74112d81cec9c59be
https://doi.org/10.1021/acs.jmedchem.1c01178
https://doi.org/10.1021/acs.jmedchem.1c01178
Autor:
Carina Lemke, Adéla Jílková, Dominic Ferber, Annett Braune, Anja On, Patrick Johe, Alena Zíková, Tanja Schirmeister, Michael Mareš, Martin Horn, Michael Gütschow
Publikováno v:
Chemistry – A European Journal. 28
Rhodesain is the major cysteine protease of the protozoan parasite Trypanosoma brucei and a therapeutic target for sleeping sickness, a fatal neglected tropical disease. We designed, synthesized and characterized a bimodal activity-based probe that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27d0522b3aa25a7d720c8994aa3d3b7
https://doi.org/10.1002/chem.202201636
https://doi.org/10.1002/chem.202201636
Publikováno v:
Acta Crystallogr D Struct Biol
Structures of BbKI, a recombinant Kunitz-type serine protease inhibitor fromBauhinia bauhinioides, complexed with human kallikrein 4 (KLK4) were determined at medium-to-high resolution in four crystal forms (space groupsP3121,P6522,P21andP61). Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ac870589b196e2860328e5d6584e95
https://doi.org/10.1107/s2059798321006483
https://doi.org/10.1107/s2059798321006483
Autor:
Michal Buša, Zuzana Matoušková, Pavla Bartošová-Sojková, Petr Pachl, Pavlína Řezáčová, Ramon Marc Eichenberger, Peter Deplazes, Martin Horn, Saša Štefanić, Michael Mareš
Publikováno v:
Journal of Biological Chemistry. 299:102970
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b3c2751370a3ffb701ffff57e75d26
https://doi.org/10.1016/j.jbc.2023.102970
https://doi.org/10.1016/j.jbc.2023.102970
Autor:
Pavla Fajtová, Jim Küppers, Jindřich Fanfrlík, Michael Mareš, Marta Chanová, Petr Pachl, Adéla Jílková, Conor R. Caffrey, Martin Lepšík, Pavlína Řezáčová, Michael Gütschow, Martin Horn, Petra Rubešová
Publikováno v:
ACS Infectious Diseases
Azapeptide nitriles are postulated to reversibly covalently react with the active-site cysteine residue of cysteine proteases and form isothiosemicarbazide adducts. We investigated the interaction of azadipeptide nitriles with the cathepsin B1 drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c7375e2e725eab96a930e5400b7d91
http://europepmc.org/articles/PMC7802074
http://europepmc.org/articles/PMC7802074
Autor:
Pavla Fajtová, Saša Štefanić, Martin Hradilek, Jan Dvořák, Jiří Vondrášek, Adéla Jílková, Lenka Ulrychová, James H McKerrow, Conor R Caffrey, Michael Mareš, Martin Horn
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003827 (2015)
Blood flukes of the genus Schistosoma cause schistosomiasis, a parasitic disease that infects over 240 million people worldwide, and for which there is a need to identify new targets for chemotherapeutic interventions. Our research is focused on Schi
Externí odkaz:
https://doaj.org/article/22076b38bc044fd5bb9ceba19797d471
Autor:
Edgar Schmitt, Natascha Stergiou, Helena Langhansová, Eric Calvo, Michail Kotsyfakis, Alexandra Schwarz, Jan Kotál, Michael Mareš, Zuzana Beránková, Jan Kopecký, Pavlína Řezáčová, Adéla Chlastáková, Jindřich Chmelař, Michal Buša
Publikováno v:
Cellular and Molecular Life Sciences. 76:2003-2013
To successfully feed, ticks inject pharmacoactive molecules into the vertebrate host including cystatin cysteine protease inhibitors. However, the molecular and cellular events modulated by tick saliva remain largely unknown. Here, we describe and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86b33541ef7165df6258ab5640f7cb7
https://doi.org/10.1007/s00018-019-03034-3
https://doi.org/10.1007/s00018-019-03034-3