Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael Marconi"'
Autor:
Kelley C. Larson, Lauren H. Martens, Michael Marconi, Christopher Dejesus, Suzanne Bruhn, Thomas A. Miller, Barbara Tate, Jonathan M. Levenson
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Neuroinflammation is a key driver of neurodegenerative disease, however the tools available to model this disease biology at the systems level are lacking. We describe a translational drug discovery platform based on organotypic culture of m
Externí odkaz:
https://doaj.org/article/f99fd718d187495393c0c52cd3dd9f64
Autor:
Erica C. Dresselhaus, Leah Cleary, Gayathri Ramaswamy, Michael Marconi, Patrick Robert Verhoest, Edel Evrard, Uthpala Seneviratne, Christopher amEnde, Martin Pettersson, Ethan Lawrence Fisher, Jamison B. Tuttle, Lorraine F. Lanyon, Longfei Xie, Emily Sylvain, Travis T. Wager, Butler Todd W, John M. Humphrey, Claire M. Steppan, Simone Sciabola, Douglas Scott Johnson, Zhen Huang, Christopher J Helal, Michael Eric Green, Paramita Mukherjee
Publikováno v:
SSRN Electronic Journal.
Apolipoprotein E (apoE) is a 34 kDa key lipid transport protein in both the brain and the periphery. In the brain, it is produced predominantly by astrocytes and has been shown to play an important role in promoting neurite outgrowth and synaptogenes
Autor:
Angela C. Doran, Cheng Chang, Shenping Liu, Butler Todd W, Travis T. Wager, Klaas Schildknegt, Lei Zhang, Michael Marconi, Jianke Li, Scot Richard Mente, Katherine Fisher, Ramalakshmi Yegna Chandrasekaran, Joseph R. Hedde, Sarah Grimwood, Chakrapani Subramanyam, Paul Galatsis
Publikováno v:
ACS Chemical Neuroscience. 8:1995-2004
To enable the clinical development of our CNS casein kinase 1 delta/epsilon (CK1δ/e) inhibitor project, we investigated the possibility of developing a CNS positron emission tomography (PET) radioligand. For this effort, we focused our design and sy
Autor:
Christopher W. am Ende, Ethan Lawrence Fisher, Erica C. Dresselhaus, Leah Cleary, John M. Humphrey, Edelweiss Evrard, Douglas S. Johnson, Patrick Robert Verhoest, Jamison B. Tuttle, Travis T. Wager, Longfei Xie, Emily Sylvain, Zhen Huang, Martin Pettersson, Uthpala Seneviratne, Lorraine F. Lanyon, Michael Marconi, Claire M. Steppan, Gayathri Ramaswamy, Simone Sciabola, Christopher John Helal, Michael Eric Green, Butler Todd W, Paramita Mukherjee
Publikováno v:
Cell Chem Biol
Summary Utilizing a phenotypic screen, we identified chemical matter that increased astrocytic apoE secretion in vitro. We designed a clickable photoaffinity probe based on a pyrrolidine lead compound and carried out probe-based quantitative chemical
Autor:
Jermaine Ross, Kelley C. Larson, Sarah Kolitz, Thomas A. Miller, Michael Marconi, Matthew Ung, Barbara Tate, Jonathan M. Levenson, Lauren H. Martens, Rebecca Kusko, Rob Nunes, Ben Zeskind, Christopher D. Dejesus
Publikováno v:
Alzheimer's & Dementia. 15:P947-P947
High throughput object-based image analysis of β-amyloid plaques in human and transgenic mouse brain
Autor:
Diane Stephenson, Santos Carvajal-Gonzalez, Jan Schreiber, Kelly R. Bales, Anthony J. Milici, Sharon M. O’Neill, Alan C. Opsahl, Jessie Qian, Barbara Tate, Michael Marconi, Harry Samaroo
Publikováno v:
Journal of Neuroscience Methods. 204:179-188
Advances in imaging technology have enabled automated approaches for quantitative image analysis. In this study, a high content object based image analysis method was developed for quantification of β-amyloid (Aβ) plaques in postmortem brains of Al
Autor:
Kelly R. Bales, Eva Hajos-Korcsok, Martin Pettersson, Dmitri Volfson, Cathleen Gonzales, Feng Pan, Ashley Robshaw, Michael Marconi, David Riddell, Kathleen M. Wood, Nikolay Pozdnyakov
Publikováno v:
Alzheimer's & Dementia. 11
Autor:
Kevin M. Walton, Jeff Ohren, John D. Knafels, Amy Rosado, Travis T. Wager, Butler Todd W, Andy N. Mead, Blossom Sneed, Katherine Fisher, David Horton, Shenping Liu, George J DeMarco, Scot Richard Mente, Helen Berke, Angela C. Doran, Cheng Chang, Jenifer Bradley, Michael Marconi, Ramalakshmi Yegna Chandrasekaran, David M. Rubitski
Publikováno v:
ACS chemical neuroscience. 5(12)
Casein kinase 1 delta (CK1δ) and casein kinase 1 epsilon (CK1ε) inhibitors are potential therapeutic agents for a range of psychiatric disorders. The feasibility of developing a CNS kinase inhibitor has been limited by an inability to identify safe
Autor:
Kelly R. Bales, Simone P. Zehntner, Kathleen M. Wood, Eric M. Parker, Felix Carbonell, Michael Marconi, Barry J. Bedell, Alex P. Zijdenbos, Thomas W. Rosahl
Publikováno v:
Alzheimer's & Dementia. 10
STUDIESOFGAMMA-SECRETASE INHIBITION IN AN APP-SW MOUSE MODEL OFALZHEIMER’S DISEASE Barry J. Bedell, Simone P. Zehntner, Thomas Rosahl, Kathleen Wood, Kelly R. Bales, Michael A. Marconi, Eric Parker, Felix Carbonell, Alex P. Zijdenbos, Biospective I
Autor:
John M. Humphrey, Shenping Liu, Jeff Ohren, Katherine Fisher, Ramalakshmi Yegna Chandrasekaran, Kevin M. Walton, Kevin Cherry, Butler Todd W, W. Scott McDonald, Eric P. Arnold, Jianke Li, Ken Dirico, Angela C. Doran, Blossom Sneed, Travis T. Wager, Subramanyam Chakrapani, Michael Eric Green, Scot Richard Mente, John D. Knafels, Matthew Merrill Hayward, Paul Galatsis, Vanessa Paradis, Michael Marconi
Publikováno v:
Journal of medicinal chemistry. 56(17)
Casein kinase 1δ (CK1δ) and 1e (CK1e) are believed to be necessary enzymes for the regulation of circadian rhythms in all mammals. On the basis of our previously published work demonstrating a CK1e-preferring compound to be an ineffective circadian