Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michael Man‐Chu Lo"'
Autor:
Clayton D. Knox, Pieter‐Jan deKam, Karim Azer, Peggy Wong, Antwan G. Ederveen, Diane Shevell, Christopher Morabito, Alan G. Meehan, Wen Liu, Tom Reynders, Jean Francois Denef, Anna Mitselos, Daniel Jonathan, David E. Gutstein, Kaushik Mitra, Shu Yu Sun, Michael Man‐Chu Lo, Doris Cully, Amjad Ali
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)
Background Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we descri
Externí odkaz:
https://doaj.org/article/7cd174d677244bd59548edc692b1ac0a
Publikováno v:
The Journal of Organic Chemistry. 85:4807-4812
The therapeutic application of nitric oxide, an endogenous cellular signaling molecule, has been limited due to the difficulty of developing stable pro-drugs with slow kinetics of NO release. Diazeniumdiolates are valuable NO donors; however, synthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48e5529960a6e0702578b8db27d6e9f
https://doi.org/10.1021/acs.joc.0c00020
https://doi.org/10.1021/acs.joc.0c00020
Autor:
John A. Morrow, Robert Mazzola, Cristian Salinas, Eric D. Hostetler, Stefania Risso, Fiona Thomson, Tjerk Bueters, Nicholas B. Hastings, Jenny Wai, Sony Agrawal, Liza Gantert, Brian C. Magliaro, Paul McQuade, Zhizhen Zeng, Marie A. Holahan, David Hesk, Melissa Egbertson, Jeffrey W. Schubert, Ling Tong, Robert Gomez, Jongrock Kong, Aniket Joshi, Frederick J. Monsma, David M. Tellers, Kristen L.G. Jones, Jason M. Uslaner, Jing Liao, Patricia Miller, Michelle Smith, Oleg Selyutin, Kerry Riffel, Xiaolei Gao, Scott T. Harrison, Zhaoyang Meng, James Mulhearn, Michael Man-Chu Lo, Wenping Li, Michael T. Rudd, Barbara Hanney, Mona Purcell, Jianming Bao, Hyking Haley
Publikováno v:
Journal of Medicinal Chemistry. 63:2411-2425
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::949c4dbede58ed2de44d27f608635d36
https://doi.org/10.1021/acs.jmedchem.9b01406
https://doi.org/10.1021/acs.jmedchem.9b01406
Autor:
Ling, Tong, Wenping, Li, Michael Man-Chu, Lo, Xiaolei, Gao, Jenny Miu-Chen, Wai, Michael, Rudd, David, Tellers, Aniket, Joshi, Zhizhen, Zeng, Patricia, Miller, Cristian, Salinas, Kerry, Riffel, Hyking, Haley, Mona, Purcell, Marie, Holahan, Liza, Gantert, Jeffrey W, Schubert, Kristen, Jones, James, Mulhearn, Melissa, Egbertson, Zhaoyang, Meng, Barbara, Hanney, Robert, Gomez, Scott T, Harrison, Paul, McQuade, Tjerk, Bueters, Jason, Uslaner, John, Morrow, Fiona, Thomson, Jongrock, Kong, Jing, Liao, Oleg, Selyutin, Jianming, Bao, Nicholas B, Hastings, Sony, Agrawal, Brian C, Magliaro, Frederick J, Monsma, Michelle D, Smith, Stefania, Risso, David, Hesk, Eric, Hostetler, Robert, Mazzola
Publikováno v:
Journal of medicinal chemistry. 63(5)
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd3ef3c047c980065bd64efde0a0b7e9
https://pubmed.ncbi.nlm.nih.gov/32101422
https://pubmed.ncbi.nlm.nih.gov/32101422
Autor:
Rolf W. Hartmann, Qingzhong Hu, Amjad Ali, Edward Metzger, Juliette Emmerich, Lina Yin, Michael Man-Chu Lo
Publikováno v:
Journal of Medicinal Chemistry. 57:5179-5189
Pathologically, high levels of aldosterone are associated with severe cardiovascular diseases such as congestive heart failure, hypertension, and myocardial fibrosis. The inhibition of aldosterone synthase (CYP11B2) to reduce aldosterone levels has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9085a09a470f89a85f0cb9a9ae3a4190
https://doi.org/10.1021/jm500140c
https://doi.org/10.1021/jm500140c
Autor:
David E. Gutstein, Christopher J. Morabito, Anna Mitselos, Kaushik Mitra, Wen Liu, Peggy H. Wong, Doris F. Cully, Karim Azer, Shu Yu Sun, Clayton D. Knox, Antwan G. Ederveen, Pieter‐Jan de Kam, Michael Man-Chu Lo, Tom Reynders, Alan G. Meehan, Daniel Jonathan, Amjad Ali, Jean Francois Denef, Diane Shevell
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)
Background Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402e3bef922e3d1888227722e6fba249
http://europepmc.org/articles/PMC5079016
http://europepmc.org/articles/PMC5079016
Autor:
Qingzhong Hu, Scott B. Hoyt, Paul Ratcliffe, Michael Man-Chu Lo, Amjad Ali, Rolf W. Hartmann, Edward Metzger, Jonathan Bennett, Lina Yin, Andrew J. Cooke
Publikováno v:
Journal of medicinal chemistry. 58(5)
CYP11B2 inhibition is a promising treatment for diseases caused by excessive aldosterone. To improve the metabolic stability in human liver miscrosomes of previously reported CYP11B2 inhibitors, modifications were performed via a combination of ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a167ca9bad459bc327adb61ea53b89
https://pubmed.ncbi.nlm.nih.gov/25711516
https://pubmed.ncbi.nlm.nih.gov/25711516