Zobrazeno 1 - 10 of 41 pro vyhledávání: '"Michael Maddens"'
1
Akademický článek
Utilization of a breast cancer risk assessment tool by internal medicine residents in a primary care clinic: impact of an educational program
Autor: Siddhartha Yadav, Sarah Hartkop, Paola Yumpo Cardenas, Rand Ladkany, Alexandra Halalau, Sandor Shoichet, Michael Maddens, Dana Zakalik
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background Despite strong evidence of benefit, breast cancer risk assessment and chemoprevention are underutilized by primary care physicians. This study evaluates the impact of an educational program on knowledge and utilization of the NCI
Externí odkaz: https://doaj.org/article/b8828fe1f4db46b58e2ab02dc970a4d7
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2
Akademický článek
Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.
Autor: Ray O Bahado-Singh, Sangeetha Vishweswaraiah, Buket Aydas, Ali Yilmaz, Raghu P Metpally, David J Carey, Richard C Crist, Wade H Berrettini, George D Wilson, Khalid Imam, Michael Maddens, Halil Bisgin, Stewart F Graham, Uppala Radhakrishna
Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0248375 (2021)
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l
Externí odkaz: https://doaj.org/article/d9537ca420cb4d748465ee176c2f4948
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3
Akademický článek
Artificial Intelligence and Circulating Cell-Free DNA Methylation Profiling: Mechanism and Detection of Alzheimer’s Disease
Autor: Ray O. Bahado-Singh, Uppala Radhakrishna, Juozas Gordevičius, Buket Aydas, Ali Yilmaz, Faryal Jafar, Khaled Imam, Michael Maddens, Kshetra Challapalli, Raghu P. Metpally, Wade H. Berrettini, Richard C. Crist, Stewart F. Graham, Sangeetha Vishweswaraiah
Publikováno v: Cells, Vol 11, Iss 11, p 1744 (2022)
Background: Despite extensive efforts, significant gaps remain in our understanding of Alzheimer’s disease (AD) pathophysiology. Novel approaches using circulating cell-free DNA (cfDNA) have the potential to revolutionize our understanding of neuro
Externí odkaz: https://doaj.org/article/26aa0b56552f485dae0c87a376ca3611
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4
Akademický článek
Metabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson’s Disease: A Pilot Study
Autor: Ali Yilmaz, Zafer Ugur, Ilyas Ustun, Sumeyya Akyol, Ray O. Bahado-Singh, Michael Maddens, Jan O. Aasly, Stewart F. Graham
Publikováno v: Cells, Vol 9, Iss 11, p 2394 (2020)
CSF from unique groups of Parkinson’s disease (PD) patients was biochemically profiled to identify previously unreported metabolic pathways linked to PD pathogenesis, and novel biochemical biomarkers of the disease were characterized. Utilizing bot
Externí odkaz: https://doaj.org/article/271de77f580c4175a68e23da7922feda
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5
Akademický článek
Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease
Autor: Stewart F. Graham, Nolwen L. Rey, Zafer Ugur, Ali Yilmaz, Eric Sherman, Michael Maddens, Ray O. Bahado-Singh, Katelyn Becker, Emily Schulz, Lindsay K. Meyerdirk, Jennifer A. Steiner, Jiyan Ma, Patrik Brundin
Publikováno v: Metabolites, Vol 8, Iss 4, p 71 (2018)
For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodromal phases of the d
Externí odkaz: https://doaj.org/article/0003ce4bbc2641999a3bd8d919795571
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6
Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice
Autor: Katie Buelow, James Fontanesi, Alaa Hanna, Barbara L. Pruetz, Prakash Chinnaiyan, Michael Maddens, Alvaro Martinez, Justin Kulchycki, George S. Wilson, Thomas G. Wilson, Giovanni Fontanesi, Daniel B. Michael
Publikováno v: Journal of Alzheimer's Disease. 75:15-21
We have previously reported that low doses of external beam ionizing irradiation reduced amyloid-β (Aβ) plaques and improved cognition in APP/PS1 mice. In this study we investigated the effects of radiation in an age-matched series of 3xTg-AD mice.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a2abfdf14ae7535647e1c1790df3d7
https://doi.org/10.3233/jad-200030
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8
Lipid Profiling of Alzheimer’s Disease Brain Highlights Enrichment in Glycerol(phospho)lipid, and Sphingolipid Metabolism
Autor: Bernadette McGuinness, Michael Maddens, Patrick G. Kehoe, Peter Passmore, Santosh Kapil Kumar Gorti, Brian D. Green, Stewart F. Graham, Ilyas Ustun, Kyungjoon Oh, Sumeyya Akyol, Ali Yilmaz, Zafer Ugur
Publikováno v: Akyol, S, Ugur, Z, Yilmaz, A, Ustun, I, Gorti, S K K, Oh, K, McGuinness, B, Passmore, P, Kehoe, P G, Maddens, M E, Green, B D & Graham, S F 2021, ' Lipid Profiling of Alzheimer’s Disease Brain Highlights Enrichment in Glycerol(phospho)lipid, and Sphingolipid Metabolism ', Cells, vol. 10, no. 10, 2591 . https://doi.org/10.3390/cells10102591
Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2591, p 2591 (2021)
Alzheimer’s disease (AD) is reported to be closely linked with abnormal lipid metabolism. To gain a more comprehensive understanding of what causes AD and its subsequent development, we profiled the lipidome of postmortem (PM) human brains (neocort
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e066e3bfe5f063a32dd6607f052061
https://pure.qub.ac.uk/en/publications/lipid-profiling-of-alzheimers-disease-brain-highlights-enrichment-in-glycerolphospholipid-and-sphingolipid-metabolism(d540628a-9ac2-40ea-b443-85965feac9d0).html
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9
A Community-Based Study Identifying Metabolic Biomarkers of Mild Cognitive Impairment and Alzheimer's Disease Using Artificial Intelligence and Machine Learning
Autor: Michael Maddens, William T. Hu, Sumeyya Akyol, Ilyas Ustun, Ali Yilmaz, Massimo S. Fiandaca, Stewart F. Graham, Mark Mapstone, Howard J. Federoff, Zafer Ugur
Publikováno v: Journal of Alzheimer's disease : JAD. 78(4)
Background: Currently, there is no objective, clinically available tool for the accurate diagnosis of Alzheimer’s disease (AD). There is a pressing need for a novel, minimally invasive, cost friendly, and easily accessible tool to diagnose AD, asse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673d4c8efc96d34cadfeebb59d02a52c
https://pubmed.ncbi.nlm.nih.gov/33164929
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10
Evidence that the Kennedy and polyamine pathways are dysregulated in human brain in cases of dementia with Lewy bodies
Autor: Bernadette McGuinness, Peter Passmore, Patrick G. Kehoe, Kyung Joon Oh, Buket Aydas, Brian D. Green, Michael Maddens, Zafer Ugur, Stewart F. Graham, Sumeyya Akyol, Ali Yilmaz
Publikováno v: Akyol, S, Yilmaz, A, Joon Oh, K, Ugur, Z, Aydas, B, McGuinness, B, Passmore, P, Kehoe, P G, Maddens, M, Green, B D & Graham, S F 2020, ' Evidence that the Kennedy and polyamine pathways are dysregulated in human brain in cases of dementia with Lewy bodies ', Brain Research, vol. 1743, 146897 . https://doi.org/10.1016/j.brainres.2020.146897
Disruptions of brain metabolism are considered integral to the pathogenesis of dementia, but thus far little is known of how dementia with Lewy bodies (DLB) impacts the brain metabolome. DLB is less well known than other neurodegenerative diseases su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27bbd6c69f55c067fcae65b5a95be023
https://hdl.handle.net/1983/137c38bd-097d-4dd2-96db-7ad9020c899e
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