Utility of flow cytometry screening before MRD testing in multiple myeloma

Autor: Vandana Panakkal, Arjun Lakshman, Min Shi, Horatiu Olteanu, Pedro Horna, Michael M. Timm, Gregory E. Otteson, Linda B. Baughn, Patricia T. Greipp, Wilson I. Gonsalves, Prashant Kapoor, Morie A. Gertz, Moritz Binder, Francis K. Buadi, Angela Dispenzieri, S. Vincent Rajkumar, Shaji K. Kumar, Dragan Jevremovic

Publikováno v: Blood Cancer Journal, Vol 13, Iss 1, Pp 1-3 (2023)

Externí odkaz: https://doaj.org/article/32fc576a1aac41628a04ca9894e9af0f

Measurement of the Proliferation of Clonal Plasma Cells By Multiparametric Flow Cytometry Is a Clinically Useful Tool in Multiple Myeloma

Autor: Samith T. Kochuparambil, William G. Morice, S. Vincent Rajkumar, Angela Dispenzieri, Michael M Timm, Martha Q Lacy, Morie A Gertz, Shaji Kumar

Publikováno v: Blood. 124:2053-2053

Background: Proliferation rate of plasma cells (PC) is a powerful tool in evaluating all types of monoclonal gammopathies, predicting for progression as well as survival in all phases of the disease. A flow cytometry (FC)-based method to delineate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ff590c89fae748274e9d9da2af2efff
https://doi.org/10.1182/blood.v124.21.2053.2053

Single cell proteogenomic analysis of aberrant monocytosis in TET2 mutant premalignant and malignant hematopoiesis.

Autor: Lasho T; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Finke C; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Timm M; Department of Laboratory Medicine and Pathology, Hematopathology, Mayo Clinic, Rochester, MN, USA., Tefferi A; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Mangaonkar A; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Olteanu H; Department of Laboratory Medicine and Pathology, Hematopathology, Mayo Clinic, Rochester, MN, USA., Reichard K; Department of Laboratory Medicine and Pathology, Hematopathology, Mayo Clinic, Rochester, MN, USA., Ketterling R; Department of Laboratory Medicine and Pathology, Hematopathology, Mayo Clinic, Rochester, MN, USA., Gangat N; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Xie Z; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Fernandez J; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Chia N; Department of Laboratory Medicine and Pathology, Surgical Research, Mayo Clinic, Rochester, MN, USA., Gaspar-Maia A; Department of Laboratory Medicine and Pathology, Experimental Pathology, Mayo Clinic, Rochester, MN, USA., Binder M; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Patnaik MM; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. Patnaik.mrinal@mayo.edu.

Publikováno v: Leukemia [Leukemia] 2023 Jun; Vol. 37 (6), pp. 1384-1387. Date of Electronic Publication: 2023 Mar 25.

Mate pair sequencing outperforms fluorescence in situ hybridization in the genomic characterization of multiple myeloma.

Autor: Smadbeck J; Center for Individualized Medicine-Biomarker Discovery, Mayo Clinic, Rochester, MN, USA., Peterson JF; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Pearce KE; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Pitel BA; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Figueroa AL; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Timm M; Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Jevremovic D; Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Shi M; Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Stewart AK; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA., Braggio E; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA., Riggs DL; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA., Bergsagel PL; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA., Vasmatzis G; Center for Individualized Medicine-Biomarker Discovery, Mayo Clinic, Rochester, MN, USA., Kearney HM; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Hoppman NL; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Ketterling RP; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Kumar S; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Rajkumar SV; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Greipp PT; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Baughn LB; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. baughn.linda@mayo.edu.

Publikováno v: Blood cancer journal [Blood Cancer J] 2019 Dec 16; Vol. 9 (12), pp. 103. Date of Electronic Publication: 2019 Dec 16.

Plasma cell proliferative index post-transplant is a powerful predictor of prognosis in myeloma patients failing to achieve a complete response.

Autor: Sidiqi MH; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Aljama MA; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Jevremovic D; Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, USA., Morice WG; Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, USA., Timm M; Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, USA., Buadi FK; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Warsame R; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Lacy MQ; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Dispenzieri A; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Dingli D; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Gonsalves WI; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Kumar S; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Kapoor P; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Kourelis T; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Leung N; Division of Nephrology and Hypertension, Mayo Clinic Rochester, Rochester, USA., Hogan WJ; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Muchtar E; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Lust JA; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Rajkumar VS; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA., Gertz MA; Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA. gertz.morie@mayo.edu.

Publikováno v: Bone marrow transplantation [Bone Marrow Transplant] 2019 Mar; Vol. 54 (3), pp. 442-447. Date of Electronic Publication: 2018 Aug 07.