Zobrazeno 1 - 10
of 283
pro vyhledávání: '"Michael M. Shen"'
Autor:
Maher Hanoun, Anna Arnal-Estapé, Maria Maryanovich, Ali H. Zahalka, Sarah K. Bergren, Chee W. Chua, Avigdor Leftin, Patrik N. Brodin, Michael M. Shen, Chandan Guha, Paul S. Frenette
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1201-1211 (2019)
Summary: In the prostate, stem and progenitor cell regenerative capacities have been ascribed to both basal and luminal epithelial cells. Here, we show that a rare subset of mesenchymal cells in the prostate are epithelial-primed Nestin-expressing ce
Externí odkaz:
https://doaj.org/article/15df5a89ccbf40da95f5ba68658f136d
Autor:
Alvaro Aytes, Arianna Giacobbe, Antonina Mitrofanova, Katia Ruggero, Joanna Cyrta, Juan Arriaga, Luis Palomero, Sonia Farran-Matas, Mark A. Rubin, Michael M. Shen, Andrea Califano, Cory Abate-Shen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Identifying cell intrinsic mechanisms promoting metastasis are necessary to develop new cancer therapeutics. Here they do cross-species computational analysis and identify nuclear receptor binding SET domain Protein 2 (NSD2) as a driver of prostate c
Externí odkaz:
https://doaj.org/article/64e525ee05e54b2cbb33506e939b3948
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that ca
Externí odkaz:
https://doaj.org/article/0e59c496500743b6be34bd70195b16c2
Publikováno v:
Stem Cell Reports, Vol 6, Iss 5, Pp 660-667 (2016)
Contact with the extracellular matrix is essential for maintenance of epithelial cells in many tissues, while in its absence epithelial cells can detach and undergo anoikis. Here, we show that anoikis of luminal cells in the prostate epithelium is fo
Externí odkaz:
https://doaj.org/article/82631b485f264fe592163d4cdfce5250
Autor:
Antonina Mitrofanova, Alvaro Aytes, Min Zou, Michael M. Shen, Cory Abate-Shen, Andrea Califano
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 2060-2071 (2015)
Although genetically engineered mouse (GEM) models are often used to evaluate cancer therapies, extrapolation of such preclinical data to human cancer can be challenging. Here, we introduce an approach that uses drug perturbation data from GEM models
Externí odkaz:
https://doaj.org/article/388ce397f43d417a999e1701ccb26442
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1339-1346 (2014)
The identification of cell types of origin for cancer has important implications for tumor stratification and personalized treatment. For prostate cancer, the cell of origin has been intensively studied, but it has remained unclear whether basal or l
Externí odkaz:
https://doaj.org/article/a54ab0f34ea84a8e8a619681676eab38
Autor:
Ruth L. Vinall, Jane Q. Chen, Neil E. Hubbard, Shola S. Sulaimon, Michael M. Shen, Ralph W. DeVere White, Alexander D. Borowsky
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 6, Pp 914-920 (2012)
SUMMARY Tp53 mutations are common in human prostate cancer (CaP), occurring with a frequency of ∼30% and ∼70% in localized and metastatic disease, respectively. In vitro studies have determined several common mutations of Tp53 that have specific
Externí odkaz:
https://doaj.org/article/454ba69abae04d67869f9e4ca7a3fcc8
Autor:
Zhengping Shao, Brian J. Lee, Hanwen Zhang, Xiaohui Lin, Chen Li, Wenxia Jiang, Napon Chirathivat, Steven Gershik, Michael M. Shen, Richard Baer, Shan Zha
PARP1 is recruited and activated by DNA strand breaks, catalyzing the generation of poly-ADP-ribose (PAR) chains from NAD+. PAR relaxes chromatin and recruits other DNA repair factors, including XRCC1 and DNA Ligase 3, to maintain genomic stability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3ff5a5f348ddafd663173d43c96f1aa
https://doi.org/10.1101/2023.05.23.542022
https://doi.org/10.1101/2023.05.23.542022
Autor:
Lara F. Tshering, Fu Luo, Savanah Russ, Mariola Szenk, Diana Rubel, Karis Tutuska, James G. Rail, Gábor Balázsi, Michael M. Shen, Flaminia Talos
Publikováno v:
Developmental Cell.
Autor:
Johann de Bono, Wei Yuan, Jonathan Welti, Antje Neeb, Andrea Alimonti, Michael M. Shen, Andrea Califano, Amanda Swain, Paul Workman, Suzanne Carreira, Jian Ning, Lorenzo Buroni, Claudia Bertan, Alec Paschalis, Christina Guo, Nina Tunariu, Caterina Aversa, Pasquale Rescigno, Diletta Bianchini, Semini Sumanasuriya, Gunther Boysen, Gemma Fowler, Penny Flohr, Rita Pereira, Matthew Clarke, Abdullah Alajati, Jan Rekowski, David Dolling, Maryou Lambros, Ines Figueiredo, George Seed, Rossitza Christova, Beshara Sheehan, Adam Sharp, Martina Troiani, Daniela Brina, Ana Ferreira, Mateus Crespo, Alessandro Vasciaveo, Mariantonietta D’Ambrosio, Bora Gurel, Ruth Riisnaes, Susana Miranda, Veronica Gil
Supplementary Figure S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b481004e745444bace9c6da231be2c72
https://doi.org/10.1158/0008-5472.22582426
https://doi.org/10.1158/0008-5472.22582426