Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Michael M. Meagher"'
Autor:
Alicia D. Powers, Jason E. Drury, Christopher F. Hoehamer, Timothy D. Lockey, Michael M. Meagher
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 1-13 (2020)
Self-inactivating lentiviral vectors (LVVs) are used regularly for genetic modification of cells, including T cells and hematopoietic stem cells for cellular gene therapy. As vector demand grows, scalable and controllable methods are needed for produ
Externí odkaz:
https://doaj.org/article/7ca12dfd98754deaa8885f46dc9b1537
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 275-284 (2020)
With many ongoing clinical trials utilizing adeno-associated virus (AAV) gene therapy, it is necessary to find scalable and serotype-independent primary capture and recovery methods to allow for efficient and robust manufacturing processes. Here, we
Externí odkaz:
https://doaj.org/article/7d9ca9ada4994606ac4ef9aba144f735
Autor:
Michael W. Bishop, Paul R. Hutson, Jacquelyn A. Hank, Paul M. Sondel, Wayne L. Furman, Michael M. Meagher, Fariba Navid, Victor M. Santana
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Hu14.18K322A is a humanized anti-GD2 monoclonal antibody with a single point mutation that reduces complement-mediated cytotoxicity, with a maximum tolerated dose (MTD) of 60 mg/m2 daily for 4 days in children with recurrent/refractory neuroblastoma.
Externí odkaz:
https://doaj.org/article/940c5599493e4765891a98b5a77da59b
Autor:
Aimee C. Talleur, Amr Qudeimat, Jean-Yves Métais, Deanna Langfitt, Ewelina Mamcarz, Jeremy Chase Crawford, Sujuan Huang, Cheng Cheng, Caitlin Hurley, Renee Madden, Akshay Sharma, Ali Suliman, Ashok Srinivasan, M. Paulina Velasquez, Esther A. Obeng, Catherine Willis, Salem Akel, Seth E. Karol, Hiroto Inaba, Allison Bragg, Wenting Zheng, Sheng M. Zhou, Sarah Schell, MaCal Tuggle-Brown, David Cullins, Sagar L Patil, Ying Li, Paul G. Thomas, Caitlin Zebley, Benjamin Youngblood, Ching-Hon Pui, Timothy Lockey, Terrence L. Geiger, Michael M. Meagher, Brandon M. Triplett, Stephen Gottschalk
Publikováno v:
Blood Advances. 6:5737-5749
T cells expressing CD19-specific chimeric antigen receptors (CD19-CARs) have potent antileukemia activity in pediatric and adult patients with relapsed and/or refractory B-cell acute lymphoblastic leukemia (B-ALL). However, not all patients achieve a
Autor:
Paul G. Thomas, Jeremy Chase Crawford, Stephen Gottschalk, Aimee C. Talleur, Brandon M. Triplett, Michael M. Meagher, Catherine Willis, Timothy Lockey, Scott R. Olsen, Sanchit Trivedi, Pratibha Kottapalli, M. Paulina Velasquez, Janice M. Riberdy, Mikhail V. Pogorelyy, Jean-Yves Métais, E. Kaitlynn Allen, Anastasia A. Minervina, Robert C. Mettelman, Deanna Langfitt, Ching-Heng Chou, Hyunjin Kim, Taylor L. Wilson
Supplementary Data from Common Trajectories of Highly Effective CD19-Specific CAR T Cells Identified by Endogenous T-cell Receptor Lineages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022121b49237ed4e775f0ed1d50797c9
https://doi.org/10.1158/2159-8290.22541072
https://doi.org/10.1158/2159-8290.22541072
Autor:
Ellis J. Neufeld, Nickhill Bhakta, Nancy S. Bolous, Andrew M. Davidoff, Ulrike M. Reiss, Huiqi Wang, Carlos Rodriguez-Galindo, Amit C. Nathwani, Meenakshi Devidas, Michael M Meagher, Bryan A. Piras, Timothy W. Jacobs, Yichen Chen
Publikováno v:
Blood. 138:1677-1690
Adeno-associated virus (AAV)-mediated gene therapy is a novel treatment promising to reduce morbidity associated with hemophilia. Although multiple clinical trials continue to evaluate efficacy and safety, limited cost-effectiveness data have been pu
Autor:
Taylor L. Wilson, Hyunjin Kim, Ching-Heng Chou, Deanna Langfitt, Robert C. Mettelman, Anastasia A. Minervina, E. Kaitlynn Allen, Jean-Yves Métais, Mikhail V. Pogorelyy, Janice M. Riberdy, M. Paulina Velasquez, Pratibha Kottapalli, Sanchit Trivedi, Scott R. Olsen, Timothy Lockey, Catherine Willis, Michael M. Meagher, Brandon M. Triplett, Aimee C. Talleur, Stephen Gottschalk, Jeremy Chase Crawford, Paul G. Thomas
Publikováno v:
Cancer Discov
Current chimeric antigen receptor-modified (CAR) T-cell products are evaluated in bulk, without assessing functional heterogeneity. We therefore generated a comprehensive single-cell gene expression and T-cell receptor (TCR) sequencing data set using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5381811ae3546973a3dccf96f0848fe3
https://europepmc.org/articles/PMC9437573/
https://europepmc.org/articles/PMC9437573/
Autor:
Swati Naik, Renee M. Madden, Amanda Lipsitt, Timothy Lockey, Jennyfer Bran, Jeffrey E. Rubnitz, Jeffery Klco, Barry Shulkin, Sagar L. Patil, Sarah Schell, Jeoungeun John Park, Janice Riberdy, Na Shang, Jaquelyn T. Zoine, Jennifer Wallace, Elaine Harstead, Catherine Willis, Jean-Yves Metais, Deanna M. Langfitt, Sheng Zhou, Salem M. Akel, Michael M. Meagher, Brandon M. Triplett, Stephen Gottschalk, Mireya Paulina Velasquez
Publikováno v:
Blood. 140:4584-4585
Autor:
Timothy D. Lockey, Alicia D. Powers, Michael M Meagher, Christopher F. Hoehamer, Jason E. Drury
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 1-13 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Self-inactivating lentiviral vectors (LVVs) are used regularly for genetic modification of cells, including T cells and hematopoietic stem cells for cellular gene therapy. As vector demand grows, scalable and controllable methods are needed for produ
Autor:
Toru Takimoto, Felicia Scaggs Huang, Michelle Dickey, Karen S. Slobod, David I. Bernstein, Allen Portner, Aya Nakamura, Bart G. Jones, Mat Makowski, Charles J. Russell, Christopher Coleclough, Julia L. Hurwitz, Kristen N Buschle, Kristen Branum, Robert E. Sealy, Michael M Meagher, Monica M. McNeal
Publikováno v:
Human Vaccines & Immunotherapeutics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
SeVRSV is a replication-competent Sendai virus (SeV)-based vaccine carrying the respiratory syncytial virus (RSV) fusion protein (F) gene. Unmanipulated, non-recombinant SeV is a murine parainfluenza virus type 1 (PIV-1) and serves as a Jennerian vac