Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael M. Kaminski"'
Autor:
Robert Greensmith, Isadora T Lape, Cristian V Riella, Alexander J Schubert, Jakob J Metzger, Anand S Dighe, Xiao Tan, Bernhard Hemmer, Josefine Rau, Sarah Wendlinger, Nora Diederich, Anja Schütz, Leonardo V Riella, Michael M Kaminski
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2619-2637 (2024)
Abstract Detecting genetic variants enables risk factor identification, disease screening, and initiation of preventative therapeutics. However, current methods, relying on hybridization or sequencing, are unsuitable for point-of-care settings. In co
Externí odkaz:
https://doaj.org/article/7d2bcb1444954a0f83178a79d9c91a0b
Autor:
Simon Lagies, Roman Pichler, Tillmann Bork, Michael M. Kaminski, Kevin Troendle, Stefan Zimmermann, Tobias B. Huber, Gerd Walz, Soeren S. Lienkamp, Bernd Kammerer
Publikováno v:
Cells, Vol 8, Iss 10, p 1141 (2019)
Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminur
Externí odkaz:
https://doaj.org/article/a91776ebcf7c4988a28d0b99388a9ade
Autor:
Katherine Ilia, Nika Shakiba, Trevor Bingham, Ross D. Jones, Michael M. Kaminski, Eliezer Aravera, Simone Bruno, Sebastian Palacios, Ron Weiss, James J. Collins, Domitilla Del Vecchio, Thorsten M. Schlaeger
Publikováno v:
bioRxiv
Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient, with heterogeneity among transcription factor (TF) trajectories driving divergent cell states. Nevertheless, the impact of TF dynamics on reprogramming efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de8cfc6528e5f4ee2f132f694f1c2f3
https://europepmc.org/articles/PMC9900859/
https://europepmc.org/articles/PMC9900859/
Publikováno v:
Prof. Collins
The accurate and timely diagnosis of disease is a prerequisite for efficient therapeutic intervention and epidemiological surveillance. Diagnostics based on the detection of nucleic acids are among the most sensitive and specific, yet most such assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db902448ff9d265938953e44399d924f
https://doi.org/10.1038/s41551-021-00760-7
https://doi.org/10.1038/s41551-021-00760-7
Autor:
Roman Pichler, Ludovica Rizzo, Kevin Tröndle, Michaela Bühler, Hanna Brucker, Anna-Lena Müller, Kelli Grand, Silvia Farè, Amandine Viau, Michael M. Kaminski, E. Wolfgang Kuehn, Fritz Koch, Stefan Zimmermann, Peter Koltay, Soeren S. Lienkamp
Publikováno v:
Biomaterials. 291
Renal tubular cells frequently lose differentiation markers and physiological properties when propagated in conventional cell culture conditions. Embedding cells in 3D microenvironments or controlling their 3D assembly by bioprinting can enhance thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87e067270303ffef91c830f350a5f4b
https://pubmed.ncbi.nlm.nih.gov/36403325
https://pubmed.ncbi.nlm.nih.gov/36403325
Autor:
Marta Broto, Michael M. Kaminski, Christopher Adrianus, Nayoung Kim, Robert Greensmith, Schan Dissanayake-Perera, Alexander J. Schubert, Xiao Tan, Hyemin Kim, Anand S. Dighe, James J. Collins, Molly M. Stevens
CRISPR-based diagnostics enable specific sensing of DNA and RNA biomarkers associated with human diseases. This is achieved through the binding of guide RNAs to a complementary sequence which activates Cas enzymes to cleave reporter molecules. Curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ea181b45812a3c5f21b9641c529471
http://hdl.handle.net/10044/1/97651
http://hdl.handle.net/10044/1/97651
Autor:
Kai M. Schmidt-Ott, Amar J. Majmundar, Friedhelm Hildebrandt, Thomas M. Kitzler, Florian Buerger, Nina Mann, Maike Getwan, Sherif El Desoky, Michael M. Kaminski, Konstantin Deutsch, Tian Shen, Ana C. Onuchic-Whitford, Verena Klämbt, Jameela A. Kari, Youying Mao, Shirlee Shril, Soeren S. Lienkamp, Mohamed A. Shalaby, Max Werth, Jonathan Barasch
Publikováno v:
Nephrol Dial Transplant
Background An underlying monogenic cause of early-onset chronic kidney disease (CKD) can be detected in ∼20% of individuals. For many etiologies of CKD manifesting before 25 years of age, >200 monogenic causative genes have been identified to date,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed77a32e4120e403cdf608066d634934
https://doi.org/10.1093/ndt/gfaa215
https://doi.org/10.1093/ndt/gfaa215
Autor:
Kelli Grand, Max Bürgi, Michael M. Kaminski, Marko Vujanovic, Friedhelm Hildebrandt, Fritjof Helmchen, Thomas Brox, Özgün Çiçek, Johannes Loffing, Soeren S. Lienkamp, Fabian F. Voigt, Olaf Ronneberger, Yuxiao Xu, Nikko-Ideen Shaidani, Thomas Naert, Daniel Prata, Paulina Ogar, Helen Rankin Willsey, Marko E. Horb
Publikováno v:
DEVELOPMENT
Development (Cambridge, England)
article-version (VoR) Version of Record
Development (Cambridge, England)
article-version (VoR) Version of Record
Genome editing simplifies the generation of new animal models for congenital disorders. However, the detailed and unbiased phenotypic assessment of altered embryonic development remains a challenge. Here, we explore how deep learning (U-Net) can auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8fdb56a07ac206ce01beadd33d8e72
https://zenodo.org/record/7244644
https://zenodo.org/record/7244644
Autor:
Michael M, Kaminski, Omar O, Abudayyeh, Jonathan S, Gootenberg, Feng, Zhang, James J, Collins
Publikováno v:
Nature biomedical engineering. 5(7)
The accurate and timely diagnosis of disease is a prerequisite for efficient therapeutic intervention and epidemiological surveillance. Diagnostics based on the detection of nucleic acids are among the most sensitive and specific, yet most such assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25ae823b2b85a50059be1f44130ea389
https://pubmed.ncbi.nlm.nih.gov/34272525
https://pubmed.ncbi.nlm.nih.gov/34272525
Autor:
Soeren S. Lienkamp, Richard P. Lifton, Benjamin Dekel, Anna Carina Weiss, Friedhelm Hildebrandt, Vincent Cavaillès, Michael M. Kaminski, Amelie T. van der Ven, Tobias Bohnenpoll, Johanna Magdalena Schmidt, Rachel Shukrun, Hadas Ityel, Ali G. Gharavi, Eugen Widmeier, Weining Lu, Hagith Yonath, Jing Chen, Yair Anikster, Andreas Kispert, Nina Mann, Stuart B. Bauer, Daniella Magen, Asaf Vivante, Robert Kleta, Velibor Tasic, Shirlee Shril, Maike Getwan, Catherine Teyssier, Horia Stanescu, Simone Sanna-Cherchi
Publikováno v:
Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, American Society of Nephrology, 2017, 28 (8), pp.2364-2376. ⟨10.1681/ASN.2016060694⟩
Journal of the American Society of Nephrology, American Society of Nephrology, 2017, 28 (8), pp.2364-2376. ⟨10.1681/ASN.2016060694⟩
Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of CKD in the first three decades of life. However, for most patients with CAKUT, the causative mutation remains unknown. We identified a kindred with an autosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d40e960105ae5741287ba5bdd27a73b
https://doi.org/10.1681/asn.2016060694
https://doi.org/10.1681/asn.2016060694