Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Michael M. Cox"'
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
Deletion of the entire gene encoding the RarA protein of Escherichia coli results in a growth defect and additional deficiencies that were initially ascribed to a lack of RarA function. Further work revealed that most of the effects reflected the pre
Externí odkaz:
https://doaj.org/article/59e7c917a9b54b71b868adf0162badad
Autor:
Steven T. Bruckbauer, Joel Martin, Benjamin B. Minkoff, Mike T. Veling, Illissa Lancaster, Jessica Liu, Joseph D. Trimarco, Brian Bushnell, Anna Lipzen, Elizabeth A. Wood, Michael R. Sussman, Christa Pennacchio, Michael M. Cox
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/9e2c74055804467cbab94eff2e052071
Autor:
Steven T. Bruckbauer, Joel Martin, Benjamin B. Minkoff, Mike T. Veling, Illissa Lancaster, Jessica Liu, Joseph D. Trimarco, Brian Bushnell, Anna Lipzen, Elizabeth A. Wood, Michael R. Sussman, Christa Pennacchio, Michael M. Cox
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Ionizing radiation (IR) is lethal to most organisms at high doses, damaging every cellular macromolecule via induction of reactive oxygen species (ROS). Utilizing experimental evolution and continuing previous work, we have generated the most IR-resi
Externí odkaz:
https://doaj.org/article/a410f6fccd354099aa01f6365d29842c
Autor:
Adhirath Sikand, Malgorzata Jaszczur, Linda B. Bloom, Roger Woodgate, Michael M. Cox, Myron F. Goodman
Publikováno v:
Cells, Vol 10, Iss 5, p 1083 (2021)
In the mid 1970s, Miroslav Radman and Evelyn Witkin proposed that Escherichia coli must encode a specialized error-prone DNA polymerase (pol) to account for the 100-fold increase in mutations accompanying induction of the SOS regulon. By the late 198
Externí odkaz:
https://doaj.org/article/68c4ae62ee7a4a49968d0d9efd7a83ad
Publikováno v:
Cells, Vol 10, Iss 4, p 954 (2021)
Oxidative proteome damage has been implicated as a major contributor to cell death and aging. Protein damage and aging has been a particular theme of the recent research of Miroslav Radman. However, the study of how cellular proteins are damaged by o
Externí odkaz:
https://doaj.org/article/a4f24d79d15d43488a7e3931f73acc61
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266031 (2022)
Genome maintenance is an essential process in all cells. In prokaryotes, the RadD protein is important for survival under conditions that include DNA-damaging radiation. Precisely how RadD participates in genome maintenance remains unclear. Here we p
Externí odkaz:
https://doaj.org/article/5d4888b85554439cb0508da6b0e049f9
Publikováno v:
Nucleic Acids Research. 51:3735-3753
In Escherichia coli, the single-stranded DNA-binding protein (SSB) acts as a genome maintenance organizational hub by interacting with multiple DNA metabolism proteins. Many SSB-interacting proteins (SIPs) form complexes with SSB by docking onto its
Autor:
Debika Ojha, Malgorzata M Jaszczur, Adhirath Sikand, John P McDonald, Andrew Robinson, Antoine M van Oijen, Chi H Mak, Fabien Pinaud, Michael M Cox, Roger Woodgate, Myron F Goodman
Publikováno v:
Nucleic Acids Research. 50:6854-6869
Homologs of the mutagenic Escherichia coli DNA polymerase V (pol V) are encoded by numerous pathogens and mobile elements. We have used Rum pol (RumA′2B), from the integrative conjugative element (ICE), R391, as a model mobile element-encoded polym
Autor:
Michael M. Cox, Myron F. Goodman, James L. Keck, Antoine van Oijen, Susan T. Lovett, Andrew Robinson
Publikováno v:
Microbiology and Molecular Biology Reviews.
When replication forks encounter template lesions, one result is lesion skipping, where the stalled DNA polymerase transiently stalls, disengages, and then reinitiates downstream to leave the lesion behind in a postreplication gap. Despite considerab
Autor:
Megan E. Cherry, Katarzyna Dubiel, Camille Henry, Elizabeth A. Wood, Sarah A. Revitt-Mills, James L. Keck, Michael M. Cox, Antoine M. van Oijen, Harshad Ghodke, Andrew Robinson
Publikováno v:
bioRxiv
Single-stranded DNA gaps form within theE. colichromosome during replication, repair and recombination. However, information about the extent of ssDNA creation in the genome is limited. To complement a recent whole-genome sequencing study revealing s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ca5ba15dd60aa405178dc11b466979
https://doi.org/10.1101/2023.05.08.539320
https://doi.org/10.1101/2023.05.08.539320