Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michael M Wade Wolfe"'
Autor:
Michael M. Wade Wolfe, Shuo Guo, Lucy S. Yu, Trenton R. Vogel, Joseph W. Tucker, Nathaniel K. Szymczak
Publikováno v:
Chemical Communications. 58:11705-11708
Using nucleophilic, boron-based –CF2Ar reagents, we demonstrate three methods to form C–CF bonds: (1) nucleophilic aromatic substitution, (2) palladium catalyzed cross-coupling, and (3) nucleophilic substitution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31f61f8042c84184590982709160268
https://doi.org/10.1039/d2cc01938h
https://doi.org/10.1039/d2cc01938h
Publikováno v:
Journal of the American Chemical Society. 142:18698-18705
When subjected to arylboranes, anionic trifluoromethyl and difluorobenzyl palladium(II) complexes undergo fluoride abstraction followed by 1,1-migratory insertion. The resulting intermediate fluoroalkyl species can be induced to undergo a subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9a838a7be2e95c6792089b7f0932f6
https://doi.org/10.1021/jacs.0c09505
https://doi.org/10.1021/jacs.0c09505
Publikováno v:
Angewandte Chemie. 130:1395-1399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a1fa6e6e5c760371c92c7f61357e654
https://doi.org/10.1002/ange.201711316
https://doi.org/10.1002/ange.201711316
Publikováno v:
Journal of the American Chemical Society. 140(30)
The difluoromethyl group (R-CF2H) imparts desirable pharmacokinetic properties to drug molecules and is commonly targeted as a terminal functional group that is not amenable to further modification. Deprotonation of widely available Ar-CF2H starting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0dabf9bfaf81ad8d2196bfffcdb1bd
https://pubmed.ncbi.nlm.nih.gov/30040403
https://pubmed.ncbi.nlm.nih.gov/30040403
Publikováno v:
Angewandte Chemie (International ed. in English). 57(5)
A fluoroform-derived borazine CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92fc18e18c81f511328a78340d562dfa
https://pubmed.ncbi.nlm.nih.gov/29205733
https://pubmed.ncbi.nlm.nih.gov/29205733