Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Michael M Tymko"'
Autor:
Christopher K Willie, Michael Stembridge, Ryan L Hoiland, Michael M Tymko, Joshua C Tremblay, Alexander Patrician, Craig Steinback, Jonathan Moore, James Anholm, Prajan Subedi, Shailesh Niroula, Chris J McNeil, Ali McManus, David B MacLeod, Philip N Ainslie
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204660 (2018)
The University of British Columbia Nepal Expedition took place over several months in the fall of 2016 and was comprised of an international team of 37 researchers. This paper describes the objectives, study characteristics, organization and manageme
Externí odkaz:
https://doaj.org/article/4cca0ba07d064427bc8c651c3a6e9de1
Autor:
Michael M. Tymko
Publikováno v:
Experimental Physiology, Vol 109, Iss 4, Pp 472-473 (2024)
Externí odkaz:
https://doaj.org/article/b72dc7fd707b45bb8d8826a9aa3e92d7
Autor:
Patrice Brassard, Lawrence Labrecque, Jonathan D. Smirl, Michael M. Tymko, Hannah G. Caldwell, Ryan L. Hoiland, Samuel J. E. Lucas, André Y. Denault, Etienne J. Couture, Philip N. Ainslie
Publikováno v:
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept suggested a relatively broad mean arterial pressure range (~60–150 m
Externí odkaz:
https://doaj.org/article/b5bff2ce6f6c46edae53b5c80e2c04e8
Autor:
Lydia L. Simpson, Alexander B. Hansen, Gilbert Moralez, Sachin B. Amin, Florian Hofstaetter, Christopher Gasho, Mike Stembridge, Tony G. Dawkins, Michael M. Tymko, Philip N. Ainslie, Justin S. Lawley, Christopher M. Hearon
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R457-R469
Sympathetic transduction is reduced following chronic high-altitude (HA) exposure; however, vascular α-adrenergic signaling, the primary mechanism mediating sympathetic vasoconstriction at sea level (SL), has not been examined at HA. In nine male lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a9b62085750b6f64476bab0732909f3
https://doi.org/10.1152/ajpregu.00230.2022
https://doi.org/10.1152/ajpregu.00230.2022
Autor:
Jay M. J. R. Carr, Connor A. Howe, Travis D. Gibbons, Michael M. Tymko, Andrew R. Steele, Gustavo A. Vizcardo-Galindo, Joshua C. Tremblay, Philip N. Ainslie
Publikováno v:
Journal of Applied Physiology. 133:1356-1367
We assessed steady-state hypercapnic cerebrovascular reactivity and cerebral endothelium-dependent function, with and without α1-adrenergic blockade (Prazosin), in a placebo-controlled, double-blind, and randomized study, to assess the contribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf6c1d4ec9d556f2b8ec924615ffbd43
https://doi.org/10.1152/japplphysiol.00400.2022
https://doi.org/10.1152/japplphysiol.00400.2022
Autor:
Alexander B. Hansen, Sachin B. Amin, Florian Hofstätter, Hendrik Mugele, Lydia L. Simpson, Christopher Gasho, Tony G. Dawkins, Michael M. Tymko, Philip N. Ainslie, Francisco C. Villafuerte, Christopher M. Hearon, Justin S. Lawley, Gilbert Moralez
Publikováno v:
Am J Physiol Heart Circ Physiol
Andeans with chronic mountain sickness (CMS) and polycythemia have similar maximal oxygen uptakes to healthy Andeans. Therefore, this study aimed to explore potential adaptations in convective oxygen transport, with a specific focus on sympatheticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de64ceb331d15fb77f6e0abb9889cae2
https://doi.org/10.1152/ajpheart.00555.2021
https://doi.org/10.1152/ajpheart.00555.2021
Autor:
Gustavo Vizcardo-Galindo, Ryan L. Hoiland, Christopher Gasho, Francisco C. Villafuerte, Kaitlyn Tymko, Courtney Tymko, James D. Anholm, John D. Akins, Philip N. Ainslie, Michael M. Tymko, Travis D. Gibbons, Rachel Stone, Geoff B. Coombs, Mike Stembridge, Connor A. Howe, Damian M. Bailey, Joshua C. Tremblay, Tony G. Dawkins, Alexander Patrician, Benjamin S. Stacey, Rómulo Figueroa-Mujíca
Publikováno v:
Chest. 161:1022-1035
BACKGROUND: Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in both lowlanders and Sherpas at high altitude. In contrast, the pulmonary vasculature of Andeans with chronic mountain sickness (CMS) is resistant to iron adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b782c7ad08d714e67219d696a015ac2c
https://doi.org/10.1016/j.chest.2021.08.075
https://doi.org/10.1016/j.chest.2021.08.075
Autor:
Michael M. Tymko, Christopher K. Willie, Connor A. Howe, Ryan L. Hoiland, Rachel M. Stone, Kaitlyn Tymko, Courtney Tymko, David MacLeod, James D. Anholm, Christopher Gasho, Francisco Villafuerte, Gustavo Vizcardo-Galindo, Romulo Figueroa-Mujica, Trevor A. Day, Jordan D. Bird, Glen E. Foster, Craig D. Steinback, Julien V. Brugniaux, Benoit Champigneulle, Emeric Stauffer, Stephane Doutreleau, Samuel Verges, Erik R. Swenson, Philip N. Ainslie
Publikováno v:
Journal of Applied Physiology
Journal of Applied Physiology, 2022, 132 (2), pp.575-580. ⟨10.1152/japplphysiol.00757.2021⟩
Journal of Applied Physiology, 2022, 132 (2), pp.575-580. ⟨10.1152/japplphysiol.00757.2021⟩
International audience; High-altitude exposure results in a hyperventilatory-induced respiratory alkalosis followed by renal compensation (bicarbonaturia) to return arterial blood pH (pHa) toward sea-level values. However, acid-base balance has not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a06759ec21ddc2a913ae0344d8acadd
https://doi.org/10.1152/japplphysiol.00757.2021
https://doi.org/10.1152/japplphysiol.00757.2021
Autor:
Benjamin S. Stacey, Ryan L. Hoiland, Hannah G. Caldwell, Connor A. Howe, Tyler Vermeulen, Michael M. Tymko, Gustavo A. Vizcardo‐Galindo, Daniella Bermudez, Rómulo J. Figueroa‐Mujíica, Christopher Gasho, Edouard Tuaillon, Christophe Hirtz, Sylvain Lehmann, Nicola Marchi, Hayato Tsukamoto, Francisco C. Villafuerte, Philip N. Ainslie, Damian M. Bailey
KEY POINTS: High-altitude (HA) hypoxia has the potential to alter the structural-functional integrity of the neurovascular unit (NVU) in humans. For the first time, we examined to what extent chronic and lifelong hypoxia impacts multimodal biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ea372579d298c4f3af53e2e8ff10ca
https://hdl.handle.net/20.500.12866/13113
https://hdl.handle.net/20.500.12866/13113
Autor:
Hannah G Caldwell, Ryan L Hoiland, Kurt J Smith, Patrice Brassard, Anthony R Bain, Michael M Tymko, Connor A Howe, Jay MJR Carr, Benjamin S Stacey, Damian M Bailey, Audrey Drapeau, Mypinder S Sekhon, David B MacLeod, Philip N Ainslie
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:559-571
This study investigated trans-cerebral internal jugular venous-arterial bicarbonate ([HCO3−]) and carbon dioxide tension (PCO2) exchange utilizing two separate interventions to induce acidosis: 1) acute respiratory acidosis via elevations in arteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1654d072eafac15c20b12ce19a658131
https://doi.org/10.1177/0271678x211065924
https://doi.org/10.1177/0271678x211065924