Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly?

Autor: David C. Bulmer, Harween Dogra, Cian McGuire, Abi Belai, Michael M Tranter, Wendy J. Winchester, Eduardo José de Almeida Araújo, L. Ashley Blackshaw, James R.F. Hockley, Gareth J. Sanger, Vincent Cibert-Goton, Charles H. Knowles, Victor W S Kung

Publikováno v: Pain. 161(4)

The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f101f3b43a57a11b4f8eaf5851d7fe6
https://pubmed.ncbi.nlm.nih.gov/31790010

P086 MMP-12, a novel mediator of nociception in Crohn's disease

Autor: F. Barakat, Harween Dogra, David C. Bulmer, Michael M Tranter, Nicholas M. Croft, James O. Lindsay

Publikováno v: Journal of Crohn's and Colitis. 11:S120-S120

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fd5ae860ebfd1fc1d53d0b4a5d32837
https://doi.org/10.1093/ecco-jcc/jjx002.212

Cardiac macrophages and fibroblasts: A synergistic partnership without cellular transition.

Autor: Kasprovic DA; Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA., Jaggers RM; Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA., Tranter M; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA., Kanisicak O; Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: Onur.Kanisicak@osumc.edu.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Nov; Vol. 196, pp. 168-170. Date of Electronic Publication: 2024 Sep 19.

Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target.

Autor: Benson TW; Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH., Pike MM; Division of Epidemiology, Vanderbilt Genetics Institute, Institute of Medicine and Public Health, Nashville, TN.; Division of Nephrology and Hypertension, Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN., Spuzzillo A; Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH.; Departments of Internal Medicine and Pathology and Laboratory Medicine, Pathobiology and Molecular Medicine Graduate Program, University of Cincinnati, Cincinnati, OH., Hicks SM; Division of Genome Science and Cancer, John Curtin School of Medical Research, Australian National University, Canberra, Australia., Ali S; Division of Genome Science and Cancer, John Curtin School of Medical Research, Australian National University, Canberra, Australia., Pham M; Department of Cardiovascular Medicine, Section of Vascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH., Mix DS; Division of Vascular Surgery, Department of Surgery, University of Rochester School of Medicine, Rochester, NY., Brunner SI; Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH., Wadding-Lee C; Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH.; Departments of Internal Medicine and Pathology and Laboratory Medicine, Pathobiology and Molecular Medicine Graduate Program, University of Cincinnati, Cincinnati, OH., Conrad KA; Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH.; Departments of Internal Medicine and Pathology and Laboratory Medicine, Pathobiology and Molecular Medicine Graduate Program, University of Cincinnati, Cincinnati, OH., Russell HM; Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH.; Departments of Internal Medicine and Pathology and Laboratory Medicine, Pathobiology and Molecular Medicine Graduate Program, University of Cincinnati, Cincinnati, OH., Jennings C; Department of Cardiovascular Medicine, Section of Vascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH., Coughlin TM; Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH.; Departments of Internal Medicine and Pathology and Laboratory Medicine, Pathobiology and Molecular Medicine Graduate Program, University of Cincinnati, Cincinnati, OH., Aggarwal A; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH., Lyden S; Department of Cardiovascular Medicine, Section of Vascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH., Mani K; Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden., Björck M; Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden., Wanhainen A; Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.; Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden., Bhandari R; Department of Cardiovascular Medicine, Section of Vascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH.; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH., Lipworth-Elliot L; Division of Epidemiology, Vanderbilt Genetics Institute, Institute of Medicine and Public Health, Nashville, TN.; Division of Nephrology and Hypertension, Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN., Robinson-Cohen C; Division of Nephrology and Hypertension, Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt-O'Brien Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN., Caputo FJ; Department of Cardiovascular Medicine, Section of Vascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH., Shim S; Department of Cardiovascular Medicine, Section of Vascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH., Quesada O; Women's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, OH.; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, OH., Tourdot B; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Edwards TL; Division of Epidemiology, Vanderbilt Genetics Institute, Institute of Medicine and Public Health, Nashville, TN., Tranter M; Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH., Gardiner EE; Division of Genome Science and Cancer, John Curtin School of Medical Research, Australian National University, Canberra, Australia., Mackman N; Division of Hematology and Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Cameron SJ; Department of Cardiovascular Medicine, Section of Vascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH.; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH.; Department of Hematology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH., Owens AP 3rd; Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH.

Publikováno v: Blood [Blood] 2024 Oct 17; Vol. 144 (16), pp. 1663-1678.

Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic Aneurysms.

Autor: Benson TW, Pike MM, Spuzzillo A, Hicks SM, Pham M, Mix DS, Brunner SI, Wadding-Lee C, Conrad KA, Russell HM, Jennings C, Coughlin TM, Aggarwal A, Lyden S, Mani K, Björck M, Wanhainen A, Bhandari R, Lipworth-Elliot L, Robinson-Cohen C, Caputo FJ, Shim S, Edwards TL, Tranter M, Gardiner EE, Mackman N, Cameron SJ, Owens AP

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 03. Date of Electronic Publication: 2023 Jul 03.