Výsledky vyhledávání - "Michael M Thomson"

Akademický článek

Deep sequencing of near full-length HIV-1 genomes from plasma identifies circulating subtype C and infrequent occurrence of AC recombinant form in Southern India.

Autor: Shuba Varshini Alampalli, Michael M Thomson, Raghavan Sampathkumar, Karthi Sivaraman, Anto Jesuraj U K J, Chirag Dhar, George D Souza, Neil Berry, Annapurna Vyakarnam

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0188603 (2017)

India has the third largest number of HIV-1-infected individuals accounting for approximately 2.1 million people, with a predominance of circulating subtype C strains and a low prevalence of subtype A and A1C and BC recombinant forms, identified over

Externí odkaz: https://doaj.org/article/e9d289d0d11c4a81a96aa1690920a2ed

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Akademický článek

Sequence Analysis of In Vivo-Expressed HIV-1 Spliced RNAs Reveals the Usage of New and Unusual Splice Sites by Viruses of Different Subtypes.

Autor: Yolanda Vega, Elena Delgado, Jorge de la Barrera, Cristina Carrera, Ángel Zaballos, Isabel Cuesta, Ana Mariño, Antonio Ocampo, Celia Miralles, Sonia Pérez-Castro, Hortensia Álvarez, Isabel López-Miragaya, Elena García-Bodas, Francisco Díez-Fuertes, Michael M Thomson

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0158525 (2016)

HIV-1 RNAs are generated through a complex splicing mechanism, resulting in a great diversity of transcripts, which are classified in three major categories: unspliced, singly spliced (SS), and doubly spliced (DS). Knowledge on HIV-1 RNA splicing in

Externí odkaz: https://doaj.org/article/bbd347b2af39434598a78dd6d13bfedf

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Akademický článek

Identification of an HIV-1 BG Intersubtype Recombinant Form (CRF73_BG), Partially Related to CRF14_BG, Which Is Circulating in Portugal and Spain.

Autor: Aurora Fernández-García, Elena Delgado, María Teresa Cuevas, Yolanda Vega, Vanessa Montero, Mónica Sánchez, Cristina Carrera, María José López-Álvarez, Celia Miralles, Sonia Pérez-Castro, Gustavo Cilla, Carmen Hinojosa, Lucía Pérez-Álvarez, Michael M Thomson

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148549 (2016)

HIV-1 exhibits a characteristically high genetic diversity, with the M group, responsible for the pandemic, being classified into nine subtypes, 72 circulating recombinant forms (CRFs) and numerous unique recombinant forms (URFs). Here we characteriz

Externí odkaz: https://doaj.org/article/42ca6ec3af724c68ba40c1b4dc62c183

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Akademický článek

Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.

Autor: Yolanda Vega, Elena Delgado, Aurora Fernández-García, Maria Teresa Cuevas, Michael M Thomson, Vanessa Montero, Monica Sánchez, Ana Maria Sánchez, Lucia Pérez-Álvarez, Spanish Group for the Study of New HIV-1 Diagnoses in Galicia and Basque Country

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0125699 (2015)

Our objectives were to carry out an epidemiological surveillance study on transmitted drug resistance (TDR) among individuals newly diagnosed of HIV-1 infection during a nine year period in Spain and to assess the role of transmission clusters (TC) i

Externí odkaz: https://doaj.org/article/0cf9af7a92ff442cbdb3dc4598380d2b

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Akademický článek

Phylogeny and Phylogeography of a Recent HIV-1 Subtype F Outbreak among Men Who Have Sex with Men in Spain Deriving from a Cluster with a Wide Geographic Circulation in Western Europe.

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143325 (2015)

We recently reported the rapid expansion of an HIV-1 subtype F cluster among men who have sex with men (MSM) in the region of Galicia, Northwest Spain. Here we update this outbreak, analyze near full-length genomes, determine phylogenetic relationshi

Externí odkaz: https://doaj.org/article/5f7a3bf8988243b28f361a766e7e1482

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Akademický článek

Identification of new splice sites used for generation of rev transcripts in human immunodeficiency virus type 1 subtype C primary isolates.

Autor: Elena Delgado, Cristina Carrera, Paloma Nebreda, Aurora Fernández-García, Milagros Pinilla, Valentina García, Lucía Pérez-Álvarez, Michael M Thomson

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30574 (2012)

The HIV-1 primary transcript undergoes a complex splicing process by which more than 40 different spliced RNAs are generated. One of the factors contributing to HIV-1 splicing complexity is the multiplicity of 3' splice sites (3'ss) used for generati

Externí odkaz: https://doaj.org/article/4deffcb05f724616ac36a38de0ec3273

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Akademický článek

Identification of a HIV-1 circulating BF1 recombinant form (CRF75_BF1) of Brazilian origin that also circulates in Southwestern Europe

Autor: Joan Bacqué, Elena Delgado, Horacio Gil, Sofía Ibarra, Sonia Benito, Isabel García-Arata, María Moreno-Lorenzo, Ester Sáez de Adana, Carmen Gómez-González, Mónica Sánchez, Vanessa Montero, Michael M. Thomson

Publikováno v: Frontiers in Microbiology, Vol 14 (2023)

IntroductionThe high recombinogenic potential of HIV-1 has resulted in the generation of countless unique recombinant forms (URFs) and around 120 reported circulating recombinant forms (CRFs). Here we identify through analyses of near full-length gen

Externí odkaz: https://doaj.org/article/cb274931bad847ac90684cd24d0b2746

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Akademický článek

Factors associated with HIV-1 resistance to integrase strand transfer inhibitors in Spain: Implications for dolutegravir-containing regimens

Autor: Horacio Gil, Elena Delgado, Sonia Benito, María Moreno-Lorenzo, Michael M. Thomson, the Spanish Group for the Study of Antiretroviral Drug Resistance

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Integrase strand transfer inhibitor (INSTI)-containing regimens in HIV-1-infected patients have experienced a global increase. Recently, WHO has emphasized the need to fast-track the transition to dolutegravir (DTG)-based antiretroviral (ARV) treatme

Externí odkaz: https://doaj.org/article/8278edd83ebd4119a9759010589362c6

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