Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Michael M Shen"'
Autor:
Laura Crowley, Charles G Drake, Ran Reshef, Pawel Muranski, Aleksandar Obradovic, Timothy O’Donnell, Uri Laserson, Tiezheng Yuan, Emmanuel S Antonarakis, Zoila A Lopez-Bujanda, Thomas R Nirschl, Rodney Macedo, Alexandros Papachristodoulou, Jelani C Zarif, Mithil K Soni, Michael C Haffner, H Benjamin Larman, Michael M Shen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Prostate cancer is the second leading cause of cancer-related death in men in the USA; death occurs when patients progress to metastatic castration-resistant prostate cancer (CRPC). Although immunotherapy with the Food and Drug Administrat
Externí odkaz:
https://doaj.org/article/68b59adfee0947a7a5d02c9c65b412d8
Autor:
Laura Crowley, Francesco Cambuli, Luis Aparicio, Maho Shibata, Brian D Robinson, Shouhong Xuan, Weiping Li, Hanina Hibshoosh, Massimo Loda, Raul Rabadan, Michael M Shen
Publikováno v:
eLife, Vol 9 (2020)
Understanding the cellular constituents of the prostate is essential for identifying the cell of origin for prostate adenocarcinoma. Here, we describe a comprehensive single-cell atlas of the adult mouse prostate epithelium, which displays extensive
Externí odkaz:
https://doaj.org/article/97b0855c03e5439a823cccdc26ab4c71
Autor:
Chee Wai Chua, Nusrat J Epsi, Eva Y Leung, Shouhong Xuan, Ming Lei, Bo I Li, Sarah K Bergren, Hanina Hibshoosh, Antonina Mitrofanova, Michael M Shen
Publikováno v:
eLife, Vol 7 (2018)
Master regulatory genes of tissue specification play key roles in stem/progenitor cells and are often important in cancer. In the prostate, androgen receptor (AR) is a master regulator essential for development and tumorigenesis, but its specific fun
Externí odkaz:
https://doaj.org/article/cb375be9a2604443a71f9d6c7e3175fa
Autor:
Maher Hanoun, Anna Arnal-Estapé, Maria Maryanovich, Ali H. Zahalka, Sarah K. Bergren, Chee W. Chua, Avigdor Leftin, Patrik N. Brodin, Michael M. Shen, Chandan Guha, Paul S. Frenette
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1201-1211 (2019)
Summary: In the prostate, stem and progenitor cell regenerative capacities have been ascribed to both basal and luminal epithelial cells. Here, we show that a rare subset of mesenchymal cells in the prostate are epithelial-primed Nestin-expressing ce
Externí odkaz:
https://doaj.org/article/15df5a89ccbf40da95f5ba68658f136d
Autor:
Alvaro Aytes, Arianna Giacobbe, Antonina Mitrofanova, Katia Ruggero, Joanna Cyrta, Juan Arriaga, Luis Palomero, Sonia Farran-Matas, Mark A. Rubin, Michael M. Shen, Andrea Califano, Cory Abate-Shen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Identifying cell intrinsic mechanisms promoting metastasis are necessary to develop new cancer therapeutics. Here they do cross-species computational analysis and identify nuclear receptor binding SET domain Protein 2 (NSD2) as a driver of prostate c
Externí odkaz:
https://doaj.org/article/64e525ee05e54b2cbb33506e939b3948
Autor:
Zhengping Shao, Brian J. Lee, Hanwen Zhang, Xiaohui Lin, Chen Li, Wenxia Jiang, Napon Chirathivat, Steven Gershik, Michael M. Shen, Richard Baer, Shan Zha
PARP1 is recruited and activated by DNA strand breaks, catalyzing the generation of poly-ADP-ribose (PAR) chains from NAD+. PAR relaxes chromatin and recruits other DNA repair factors, including XRCC1 and DNA Ligase 3, to maintain genomic stability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3ff5a5f348ddafd663173d43c96f1aa
https://doi.org/10.1101/2023.05.23.542022
https://doi.org/10.1101/2023.05.23.542022
Autor:
Lara F. Tshering, Fu Luo, Savanah Russ, Mariola Szenk, Diana Rubel, Karis Tutuska, James G. Rail, Gábor Balázsi, Michael M. Shen, Flaminia Talos
Publikováno v:
Developmental Cell.
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that ca
Externí odkaz:
https://doaj.org/article/0e59c496500743b6be34bd70195b16c2
Autor:
Johann de Bono, Wei Yuan, Jonathan Welti, Antje Neeb, Andrea Alimonti, Michael M. Shen, Andrea Califano, Amanda Swain, Paul Workman, Suzanne Carreira, Jian Ning, Lorenzo Buroni, Claudia Bertan, Alec Paschalis, Christina Guo, Nina Tunariu, Caterina Aversa, Pasquale Rescigno, Diletta Bianchini, Semini Sumanasuriya, Gunther Boysen, Gemma Fowler, Penny Flohr, Rita Pereira, Matthew Clarke, Abdullah Alajati, Jan Rekowski, David Dolling, Maryou Lambros, Ines Figueiredo, George Seed, Rossitza Christova, Beshara Sheehan, Adam Sharp, Martina Troiani, Daniela Brina, Ana Ferreira, Mateus Crespo, Alessandro Vasciaveo, Mariantonietta D’Ambrosio, Bora Gurel, Ruth Riisnaes, Susana Miranda, Veronica Gil
Supplementary Figure S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b481004e745444bace9c6da231be2c72
https://doi.org/10.1158/0008-5472.22582426
https://doi.org/10.1158/0008-5472.22582426
Autor:
Johann de Bono, Wei Yuan, Jonathan Welti, Antje Neeb, Andrea Alimonti, Michael M. Shen, Andrea Califano, Amanda Swain, Paul Workman, Suzanne Carreira, Jian Ning, Lorenzo Buroni, Claudia Bertan, Alec Paschalis, Christina Guo, Nina Tunariu, Caterina Aversa, Pasquale Rescigno, Diletta Bianchini, Semini Sumanasuriya, Gunther Boysen, Gemma Fowler, Penny Flohr, Rita Pereira, Matthew Clarke, Abdullah Alajati, Jan Rekowski, David Dolling, Maryou Lambros, Ines Figueiredo, George Seed, Rossitza Christova, Beshara Sheehan, Adam Sharp, Martina Troiani, Daniela Brina, Ana Ferreira, Mateus Crespo, Alessandro Vasciaveo, Mariantonietta D’Ambrosio, Bora Gurel, Ruth Riisnaes, Susana Miranda, Veronica Gil
Supplementary methods and Supplementary figure legends - Tracked Changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7e3b640a1f0b3f9213044fa5964644
https://doi.org/10.1158/0008-5472.22582405.v1
https://doi.org/10.1158/0008-5472.22582405.v1