Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael M Maiden"'
Autor:
Michael M Maiden, Christopher M Waters
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008529 (2020)
Biofilm-based infections are difficult to treat due to their inherent resistance to antibiotic treatment. Discovering new approaches to enhance antibiotic efficacy in biofilms would be highly significant in treating many chronic infections. Exposure
Externí odkaz:
https://doaj.org/article/1cb4d3cb8c5f4fb6b5870ddbe32ce7dd
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
We demonstrate that the antimicrobial peptide, melittin, is effective alone and in combination with the aminoglycosides tobramycin to kill Pseudomonas aeruginosa growing as biofilms both in vitro and in vivo. Melittin and tobramycin show enhanced in
Externí odkaz:
https://doaj.org/article/7f42f63325a34a13be6f1304137a24fd
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008529 (2020)
PLoS Pathogens, Vol 16, Iss 10, p e1008529 (2020)
Biofilm-based infections are difficult to treat due to their inherent resistance to antibiotic treatment. Discovering new approaches to enhance antibiotic efficacy in biofilms would be highly significant in treating many chronic infections. Exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0bcf1da31a73490e6916e649f189c3
http://europepmc.org/articles/PMC7657502
http://europepmc.org/articles/PMC7657502
Autor:
Andrew B. Dippel, Christopher M. Waters, Ming C. Hammond, Michael M. Maiden, Wyatt A. Anderson
Publikováno v:
Methods Enzymol
Chemiluminescent biosensors have been developed and broadly applied to mammalian cell systems for studying intracellular signaling networks. For bacteria, biosensors have largely relied on fluorescence-based systems for quantitating signaling molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72663e867ff6dc1732f818049f958373
https://pubmed.ncbi.nlm.nih.gov/32560807
https://pubmed.ncbi.nlm.nih.gov/32560807
Publikováno v:
Journal of Antimicrobial Chemotherapy. 74:894-906
ObjectivesTo assess the ability of oxyclozanide to enhance tobramycin killing of Pseudomonas aeruginosa biofilms and elucidate its mechanism of action.MethodsTwenty-four hour biofilms formed by the P. aeruginosa strain PAO1 and cystic fibrosis (CF) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5953a68c07443be3f95973adbc9f98c
https://doi.org/10.1093/jac/dky545
https://doi.org/10.1093/jac/dky545
Autor:
Hubert H. Girault, Sandra E Mcclure, Milica Jović, Greg M. Swain, Michael M. Maiden, Andreas Lesch, Christopher M. Waters, Romana Jarošová, Margaret Gajda
Polyacrylamide-coated, carbon nanotube (PA/ CNT) electrodes were prepared by an inkjet printing process and used to measure pyocyanin and uric acid in a wound fluid simulant at 37 °C. These two molecules are potential indicators of infection, and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f379e08525f4e198c86012d92a2be907
http://hdl.handle.net/11585/691967
http://hdl.handle.net/11585/691967
Autor:
Martin E. Hurwitz, Jacob A. Gibson, Mitchell P. Zachos, Christopher M. Waters, Martha H. Mulks, Alessandra M. Agostinho Hunt, Michael M. Maiden
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
One of the most important clinical obstacles in cystic fibrosis (CF) treatment is antibiotic treatment failure due to biofilms produced by Pseudomonas aeruginosa . The ability of this pathogen to survive eradication by tobramycin and pathoadapt into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53a29720becfc5f31d2dd0440255f1d
https://doi.org/10.1128/aac.00146-18
https://doi.org/10.1128/aac.00146-18
Autor:
Geoffrey B. Severin, Christopher M. Waters, Meng Lun Hsieh, Michael M. Maiden, Benjamin R. Pursley, Nicolas L. Fernandez
3′,5′-Cyclic diguanylic acid (c-di-GMP) is a bacterial second messenger molecule that is a key global regulator in Vibrio cholerae , but the molecular mechanisms by which this molecule regulates downstream phenotypes have not been fully character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8f71415c0e81e315edf7d55676d94a
https://europepmc.org/articles/PMC5847662/
https://europepmc.org/articles/PMC5847662/
Autor:
Julie Di Bernardo, K. Sue O'Shea, Shaun M. Kunisaki, Luis G. Villa-Diaz, Omar S. Mabrouk, Guihua Jiang, Paul H. Krebsbach, Michael M. Maiden
Publikováno v:
Stem Cells and Development. 23:2613-2625
The establishment of a reliable prenatal source of autologous, transgene-free progenitor cells has enormous potential in the development of regenerative-medicine-based therapies for infants born with devastating birth defects. Here, we show that a la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11697bf3ae7418368010ad3e831143b
https://doi.org/10.1089/scd.2014.0110
https://doi.org/10.1089/scd.2014.0110
Publikováno v:
Journal of pediatric surgery. 49(6)
Purpose Recent experimental work suggests the therapeutic role of mesenchymal stromal cells (MSCs) during lung morphogenesis. The purpose of this study was to investigate the potential paracrine effects of amniotic fluid-derived MSCs (AF-MSCs) on fet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4801008f5d69f332f3fa564b08250a
https://pubmed.ncbi.nlm.nih.gov/24888823
https://pubmed.ncbi.nlm.nih.gov/24888823