Zobrazeno 1 - 10
of 507
pro vyhledávání: '"Michael M Lederman"'
Autor:
Emily R Bowman, Cheryl M Cameron, Brian Richardson, Manjusha Kulkarni, Janelle Gabriel, Morgan J Cichon, Kenneth M Riedl, Yousef Mustafa, Michael Cartwright, Brandon Snyder, Subha V Raman, David A Zidar, Susan L Koletar, Martin P Playford, Nehal N Mehta, Scott F Sieg, Michael L Freeman, Michael M Lederman, Mark J Cameron, Nicholas T Funderburg
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008869 (2020)
People with HIV (PWH) are at increased risk for atherosclerotic cardiovascular disease (ASCVD). Proportions of vascular homing monocytes are enriched in PWH; however, little is known regarding monocyte-derived macrophages (MDMs) that may drive athero
Externí odkaz:
https://doaj.org/article/09da2fd03de3473b98d561fe06dfb7c5
Autor:
Soumya Panigrahi, Bonnie Chen, Mike Fang, Daria Potashnikova, Alexey A Komissarov, Anna Lebedeva, Gillian M Michaelson, Jonathan M Wyrick, Stephen R Morris, Scott F Sieg, Mirko Paiardini, Francois J Villinger, Karem Harth, Vikram S Kashyap, Mark J Cameron, Cheryl M Cameron, Elena Vasilieva, Leonid Margolis, Souheil-Antoine Younes, Nicholas T Funderburg, David A Zidar, Michael M Lederman, Michael L Freeman
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008885 (2020)
Atherosclerotic cardiovascular disease (ASCVD) remains an important cause of morbidity in the general population and risk for ASCVD is increased approximately 2-fold in persons living with HIV infection (PLWH). This risk is linked to elevated CD8 T c
Externí odkaz:
https://doaj.org/article/ac62c44d1e6c4fe69f1c451e39acc988
Autor:
Maria Pino, Sara Paganini, Claire Deleage, Kartika Padhan, Justin L Harper, Colin T King, Luca Micci, Barbara Cervasi, Joseph C Mudd, Kiran P Gill, Sherrie M Jean, Kirk Easley, Guido Silvestri, Jacob D Estes, Constantinos Petrovas, Michael M Lederman, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008081 (2019)
Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir.
Externí odkaz:
https://doaj.org/article/317b112ab6a540088ba22b5560bb1102
Autor:
Diane Jeon, Emily G Chang, Maggie McGing, Marlena Hartman-Filson, Mathew Sommers, Eula Lewis, John R Balmes, Daniela Moisi, Michael M Lederman, Kristine A Madsen, Prescott G Woodruff, Peter W Hunt, Laurence Huang, Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223263 (2019)
BackgroundCOPD is a common HIV comorbidity, and HIV-infected individuals have a higher incidence and earlier onset of COPD compared to HIV-uninfected individuals. While the pathogenesis of HIV-associated COPD is largely unknown, chronic inflammation
Externí odkaz:
https://doaj.org/article/5ad0b4d2febd4c9babbcb4eca266ebfb
Autor:
Richard J Wang, Julia Moore, Daniela Moisi, Emily G Chang, Patrick Byanyima, Sylvia Kaswabuli, Emmanuel Musisi, Ingvar Sanyu, Abdulwahab Sessolo, Rejani Lalitha, William Worodria, J Lucian Davis, Kristina Crothers, Jue Lin, Michael M Lederman, Peter W Hunt, Laurence Huang
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216680 (2019)
IntroductionPneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.MethodsTh
Externí odkaz:
https://doaj.org/article/26f37f10fcd942b2b7a28967f2c761e7
Autor:
Michael M. Lederman, Neil Greenspan
Publikováno v:
Pathogens and Immunity, Vol 9, Iss 2 (2024)
In this interview, Dr. Anthony Fauci, who was, until recently, the director of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health, discusses the national response to the HIV/AIDS pandemic. He was the princi
Externí odkaz:
https://doaj.org/article/53cde48b562e413d81c385458052b377
Autor:
Marie R McCausland, Steven M Juchnowski, David A Zidar, Daniel R Kuritzkes, Adriana Andrade, Scott F Sieg, Michael M Lederman, Nicholas T Funderburg
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139474 (2015)
BACKGROUND:Monocytes are increasingly implicated in the inflammatory consequences of HIV-1 disease, yet their phenotype following antiretroviral therapy (ART) initiation is incompletely defined. Here, we define more completely monocyte phenotype both
Externí odkaz:
https://doaj.org/article/c8c6001f2291478ab201c4101a06a452
Autor:
Nichole R Klatt, Steven E Bosinger, Melicent Peck, Laura E Richert-Spuhler, Anke Heigele, Jillian P Gile, Nirav Patel, Jessica Taaffe, Boris Julg, David Camerini, Carlo Torti, Jeffrey N Martin, Steven G Deeks, Elizabeth Sinclair, Frederick M Hecht, Michael M Lederman, Mirko Paiardini, Frank Kirchhoff, Jason M Brenchley, Peter W Hunt, Guido Silvestri
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004345 (2014)
A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotyp
Externí odkaz:
https://doaj.org/article/eef74e25784f450da0159e4e5b448876
Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.
Autor:
Rodolphe Thiébaut, Julia Drylewicz, Mélanie Prague, Christine Lacabaratz, Stéphanie Beq, Ana Jarne, Thérèse Croughs, Rafick-Pierre Sekaly, Michael M Lederman, Irini Sereti, Daniel Commenges, Yves Lévy
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 5, p e1003630 (2014)
Exogenous Interleukin-7 (IL-7), in supplement to antiretroviral therapy, leads to a substantial increase of all CD4+ T cell subsets in HIV-1 infected patients. However, the quantitative contribution of the several potential mechanisms of action of IL
Externí odkaz:
https://doaj.org/article/c2686c9e352e4e8a8a992c7f7a8d279d
Autor:
Sergio Serrano-Villar, Talia Sainz, Sulggi A Lee, Peter W Hunt, Elizabeth Sinclair, Barbara L Shacklett, April L Ferre, Timothy L Hayes, Ma Somsouk, Priscilla Y Hsue, Mark L Van Natta, Curtis L Meinert, Michael M Lederman, Hiroyu Hatano, Vivek Jain, Yong Huang, Frederick M Hecht, Jeffrey N Martin, Joseph M McCune, Santiago Moreno, Steven G Deeks
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004078 (2014)
A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal
Externí odkaz:
https://doaj.org/article/34190c80ee49467aaee778896123b3f0