Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Michael M Kozlov"'
Autor:
Felix Campelo, Josse van Galen, Gabriele Turacchio, Seetharaman Parashuraman, Michael M Kozlov, María F García-Parajo, Vivek Malhotra
Publikováno v:
eLife, Vol 6 (2017)
The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how is this morphology achieved and is it related to its function in cargo sorting and export? A physical model of cisterna morphology led us to propose that sphingomyelin
Externí odkaz:
https://doaj.org/article/df80d5aad44a48d0a89f979a8fc413f4
Autor:
Lisi Wei, Xiaoli Guo, Ehud Haimov, Kazuki Obashi, Sung Hoon Lee, Wonchul Shin, Min Sun, Chung Yu Chan, Jiansong Sheng, Zhen Zhang, Ammar Mohseni, Sudhriti Ghosh Dastidar, Xin-Sheng Wu, Xin Wang, Sue Han, Gianvito Arpino, Bo Shi, Maryam Molakarimi, Jessica Matthias, Christian A. Wurm, Lin Gan, Justin W. Taraska, Michael M. Kozlov, Ling-Gang Wu
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-24 (2024)
Abstract Membrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve membrane coat-forming proteins, including the most observed clathrin, to form Ω-shape profiles a
Externí odkaz:
https://doaj.org/article/518300501f89466182891e0cc4c55801
Autor:
Yonatan Schweitzer, Michael M Kozlov
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 2, p e1004054 (2015)
Specialized proteins serve as scaffolds sculpting strongly curved membranes of intracellular organelles. Effective membrane shaping requires segregation of these proteins into domains and is, therefore, critically dependent on the protein-protein int
Externí odkaz:
https://doaj.org/article/0e40df4e310c4e4ca2fb4fca59388218
Autor:
Felix Campelo, Michael M Kozlov
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 4, p e1003556 (2014)
Protein domains shallowly inserting into the membrane matrix are ubiquitous in peripheral membrane proteins involved in various processes of intracellular membrane shaping and remodeling. It has been suggested that these domains sense membrane curvat
Externí odkaz:
https://doaj.org/article/af2e2da98ccc4c77bd7e890a6425fd3e
Autor:
Victor Buzon, Ganesh Natrajan, David Schibli, Felix Campelo, Michael M Kozlov, Winfried Weissenhorn
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000880 (2010)
The HIV-1 envelope glycoprotein (Env) composed of the receptor binding domain gp120 and the fusion protein subunit gp41 catalyzes virus entry and is a major target for therapeutic intervention and for neutralizing antibodies. Env interactions with ce
Externí odkaz:
https://doaj.org/article/d642bbbc55a1477d878fab8a83d1108e
Autor:
Gur Fabrikant, Suman Lata, James D Riches, John A G Briggs, Winfried Weissenhorn, Michael M Kozlov
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 11, p e1000575 (2009)
ESCRT-III proteins catalyze membrane fission during multi vesicular body biogenesis, budding of some enveloped viruses and cell division. We suggest and analyze a novel mechanism of membrane fission by the mammalian ESCRT-III subunits CHMP2 and CHMP3
Externí odkaz:
https://doaj.org/article/c9321f3bfc2b4dcf889f87856cc7d8fe
Publikováno v:
PLoS Pathogens, Vol 5, Iss 9, p e1000585 (2009)
The HIV envelope (Env) glycoprotein mediates membrane fusion through sequential interactions with CD4 and coreceptors, followed by the refolding of the transmembrane gp41 subunit into the stable 6-helix bundle (6HB) conformation. Synthetic peptides d
Externí odkaz:
https://doaj.org/article/96352af3eb2d44c394f3db3b2609fda7
Autor:
Raviv Dharan, Yuwei Huang, Sudheer Kumar Cheppali, Shahar Goren, Petr Shendrik, Weisi Wang, Jiamei Qiao, Michael M. Kozlov, Li Yu, Raya Sorkin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Migrasomes are signaling organelles that form in retraction fibers of migrating cells. Here authors show that migrasomes form by a two-stage process: an initial local membrane swelling matures and is stabilized by recruited tetraspanin proteins.
Externí odkaz:
https://doaj.org/article/d2b5ebf3c5b249b8bf78d7aedde6bdc9
Autor:
Wonchul Shin, Ben Zucker, Nidhi Kundu, Sung Hoon Lee, Bo Shi, Chung Yu Chan, Xiaoli Guo, Jonathan T. Harrison, Jaymie Moore Turechek, Jenny E. Hinshaw, Michael M. Kozlov, Ling-Gang Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Shin et al. report the molecular mechanics of membrane budding: actin and dynamin pull membrane inward to form a Λ-shape profile; dynamin helices convert Λ- to Ω-shape by constricting Λ’s base, and then constrict Ω-profile’s pore to form a v
Externí odkaz:
https://doaj.org/article/52e7b54f554c4c94b750537319d58671
Autor:
Michael M. Kozlov, Justin W. Taraska
Publikováno v:
Nature Reviews Molecular Cell Biology. 24:63-78