Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Michael M Grunstein"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118712 (2015)
Signaling by the Gβγ subunit of Gi protein, leading to downstream c-Src-induced activation of the Ras/c-Raf1/MEK-ERK1/2 signaling pathway and its upregulation of phosphodiesterase-4 (PDE4) activity, was recently shown to mediate the heightened cont
Externí odkaz:
https://doaj.org/article/1371a778516447a89025ea7a22b59d46
Autor:
Aihua Hu, Maureen B Josephson, Barry L Diener, Gustavo Nino, Shuyun Xu, Chinmay Paranjape, Jordan S Orange, Michael M Grunstein
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60452 (2013)
To elucidate the regulation of glucocorticoid receptor (GR) signaling under pro-asthmatic conditions, cultured human airway smooth muscle (HASM) cells were treated with proinflammatory cytokines or GR ligands alone and in combination, and then examin
Externí odkaz:
https://doaj.org/article/fa08da63a6df4f78ac2f5a43ab91f4a3
Autor:
Gustavo Nino, Aihua Hu, Judith S Grunstein, Joseph McDonough, Portia A Kreiger, Maureen B Josephson, John K Choi, Michael M Grunstein
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32078 (2012)
Since the Gβγ subunit of Gi protein has been importantly implicated in regulating immune and inflammatory responses, this study investigated the potential role and mechanism of action of Gβγ signaling in regulating the induction of airway hyperre
Externí odkaz:
https://doaj.org/article/de8aefe9780b474aa84d252b0771b0af
Autor:
Joseph M. McDonough, Portia A. Kreiger, Judith S. Grunstein, Junfang Jiao, Chinmay Paranjape, Gustavo Nino, Aihua Hu, Maureen B. Josephson, Y. Grumbach, Michael M. Grunstein, Shuyun Xu
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 303:L382-L390
Endogenous glucocorticoid (GC) activation is regulated by the intracellular GC-activating and -inactivating enzymes 11β-hydroxysteroid dehydrogenase (11β-HSD)1 and 11β-HSD2, respectively, that catalyze interconversion of inert cortisone and its bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0bd61c1dc8c6b1185267576e39efc2
https://doi.org/10.1152/ajplung.00125.2012
https://doi.org/10.1152/ajplung.00125.2012
Autor:
Jing Cao, Sumbul Fatma, Aihua Hu, Y. Grumbach, Michael M. Grunstein, Gustavo Nino, Judith S. Grunstein
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 296:L790-L803
The anti-inflammatory actions of endogenous glucocorticoids (GCs) are regulated by the activities of the GC-activating and -inactivating enzymes, 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 and 11beta-HSD2, respectively, that catalyze the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799c7d846f369f36b4345a83b1d42082
https://doi.org/10.1152/ajplung.90572.2008
https://doi.org/10.1152/ajplung.90572.2008
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 294:L1055-L1067
β2-Adrenergic receptor (β2AR) agonists acutely relieve bronchoconstriction via cAMP-mediated relaxation of airway smooth muscle (ASM). Airway constrictor responsiveness may be significantly heightened, however, following protracted exposure to thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b005b19750c8db2b34f5bbbdc1ce611
https://doi.org/10.1152/ajplung.00021.2008
https://doi.org/10.1152/ajplung.00021.2008
Autor:
Aihua Hu, Xiaoyin Shan, Haviva Veler, Judith S. Grunstein, Michael M. Grunstein, Sing Chuang, Sumbul Fatma
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 291:L324-L333
Activation of Toll-like receptors (TLRs) on immune surveillance cells in the lung has been implicated in the pathobiology of allergic asthma, a condition associated with altered airway smooth muscle (ASM) contractility. Because ASM is known to direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20e21c1b5ca88f0ad11afc6baf43879
https://doi.org/10.1152/ajplung.00056.2006
https://doi.org/10.1152/ajplung.00056.2006
Autor:
Judith S. Grunstein, Joshua Larson, Haviva Veler, Michael M. Grunstein, Xiaoyin Shan, Sing Chuang
Publikováno v:
Journal of Allergy and Clinical Immunology. 116:94-101
Background House dust mite allergen exposure is a key risk factor for the development of allergic asthma. Beyond provoking immune cell-mediated allergic responses, house dust mite allergens were recently shown to exert direct effects on airway struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a97e5d8a525a80f77953fe8874ff71a
https://doi.org/10.1016/j.jaci.2005.03.046
https://doi.org/10.1016/j.jaci.2005.03.046
Autor:
Hakon Hakonarson, M. Chen, Michael M. Grunstein, Judith S. Grunstein, Sing Chuang, R. Whelan, J. Leiter
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 282:L520-L528
In testing the hypothesis that interleukin-4 receptor alpha-subunit (IL-4R alpha)-coupled signaling mediates altered airway smooth muscle (ASM) responsiveness in the atopic sensitized state, isolated rabbit tracheal ASM segments were passively sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd304391872047ef3f7be6f8b831446c
https://doi.org/10.1152/ajplung.00343.2001
https://doi.org/10.1152/ajplung.00343.2001
Autor:
Sing Chuang, Judith S. Grunstein, M. Chen, R. Whelan, Michael M. Grunstein, Hakon Hakonarson, J. Leiter
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 281:L1130-L1137
To elucidate the role and mechanism of action of interleukin (IL)-10 in regulating airway smooth muscle (ASM) responsiveness in the atopic asthmatic state, isolated rabbit tracheal ASM segments were passively sensitized with serum from atopic asthmat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd144b92b830572c651294fe7e672d5
https://doi.org/10.1152/ajplung.2001.281.5.l1130
https://doi.org/10.1152/ajplung.2001.281.5.l1130