Zobrazeno 1 - 10
of 561
pro vyhledávání: '"Michael M Gottesman"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Pancreatic adenocarcinoma is one of the most aggressive and lethal forms of cancer. Chemotherapy is the primary treatment for pancreatic cancer, but resistance to the drugs used remains a major challenge. A genome-wide CRISPR interference an
Externí odkaz:
https://doaj.org/article/0a01dade22474bd7b3f5843e572dede0
Autor:
Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract In malignant glioma, cytotoxic drugs are often inhibited from accessing the tumor site due to the blood-tumor barrier (BTB). Ibrutinib, FDA-approved lymphoma agent, inhibits Bruton tyrosine kinase (BTK) and has previously been shown to indep
Externí odkaz:
https://doaj.org/article/e10420c2c7f8462fb3381665c144761c
Autor:
Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar, Michael M. Gottesman
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background A principal protective component of the mammalian blood–brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2) on the lumenal surface
Externí odkaz:
https://doaj.org/article/9a080e0214994889a3107bc9b1dea9d1
Autor:
Ming Zheng, Haili Zhang, David L Dill, J David Clark, Susan Tu, Arielle L Yablonovitch, Meng How Tan, Rui Zhang, Dan Rujescu, Manhong Wu, Lino Tessarollo, Wilfred Vieira, Michael M Gottesman, Suhua Deng, Livia S Eberlin, Richard N Zare, Jean-Martin Billard, Jean-Pierre Gillet, Jin Billy Li, Gary Peltz
Publikováno v:
PLoS Medicine, Vol 12, Iss 2, p e1001782 (2015)
We know very little about the genetic factors affecting susceptibility to drug-induced central nervous system (CNS) toxicities, and this has limited our ability to optimally utilize existing drugs or to develop new drugs for CNS disorders. For exampl
Externí odkaz:
https://doaj.org/article/b2f23056989947ef8256583d59db6011
Autor:
Kristen M Pluchino, Dominic Esposito, Janna K Moen, Matthew D Hall, James P Madigan, Suneet Shukla, Lauren V Procter, Vanessa E Wall, Thomas D Schneider, Ian Pringle, Suresh V Ambudkar, Deborah R Gill, Steven C Hyde, Michael M Gottesman
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136396 (2015)
The efflux transporter P-glycoprotein (P-gp) is an important mediator of various pharmacokinetic parameters, being expressed at numerous physiological barriers and also in multidrug-resistant cancer cells. Molecular cloning of homologous cDNAs is an
Externí odkaz:
https://doaj.org/article/e42bc219f23e4d9da14fc63f1ad60703
Autor:
Benjamin Macadangdang, Ning Zhang, Paul E Lund, Andrew H Marple, Mitsunori Okabe, Michael M Gottesman, Daniel H Appella, Chava Kimchi-Sarfaty
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17981 (2011)
Peptide nucleic acid (PNA) is known to bind with extraordinarily high affinity and sequence-specificity to complementary nucleic acid sequences and can be used to suppress gene expression. However, effective delivery into cells is a major obstacle to
Externí odkaz:
https://doaj.org/article/dd7c724cc74243beaf6fc1084a3a3355
Autor:
John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen‐An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang‐Chiao Huang
Publikováno v:
Advanced Science, Vol 11, Iss 17, Pp n/a-n/a (2024)
Abstract Glioblastoma (GBM) is hard to treat due to cellular invasion into functioning brain tissues, limited drug delivery, and evolved treatment resistance. Recurrence is nearly universal even after surgery, chemotherapy, and radiation. Photodynami
Externí odkaz:
https://doaj.org/article/d233ac9e427242cd93a9e8dabf035622
Autor:
Robert W. Robey, Andrea N. Robinson, Fatima Ali-Rahmani, Lyn M. Huff, Sabrina Lusvarghi, Shahrooz Vahedi, Jordan M. Hotz, Andrew C. Warner, Donna Butcher, Jennifer Matta, Elijah F. Edmondson, Tobie D. Lee, Jacob S. Roth, Olivia W. Lee, Min Shen, Kandice Tanner, Matthew D. Hall, Suresh V. Ambudkar, Michael M. Gottesman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Capillary endothelial cells of the human blood–brain barrier (BBB) express high levels of P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2). However, little information is available regarding ATP-binding cassette transpo
Externí odkaz:
https://doaj.org/article/d695e11725554b04bae4d6fdca65d5b1
Autor:
Ruchi P. Patel, Skyler Kuhn, Da Yin, Jordan M. Hotz, Frances A. Maher, Robert W. Robey, Michael M. Gottesman, Sachi Horibata
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100917- (2021)
Although the first line of therapy for epithelial ovarian cancer typically consists of taxane-platinum combination therapy, many patients develop a platinum-resistant tumor within a year. Several previous studies have looked at this cross-resistance
Externí odkaz:
https://doaj.org/article/33dded77f70e4fac8056743ce6baa44e
Autor:
Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Michael M. Gottesman
A principal protective component of the mammalian blood-brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded byABCB1) and ABCG2 (encoded byABCG2) on the luminal surface of endothelial cells. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa6c57bf6823051bc5419834988c1795
https://doi.org/10.1101/2023.05.18.539313
https://doi.org/10.1101/2023.05.18.539313
