T cell intrinsic Nod2 controls Th17 immunity to Candida albicans infection

Autor: Kylie Koney, Sydney J Lashley, Ellen J Lee, Emily E Vance, Dana J Philpott, Jae W Dugan, Michael M Davey, Holly L. Rosenzweig, Ruth J Napier

Publikováno v: The Journal of Immunology. 208:58.08-58.08

We recently discovered a role for Nod2 within T cells in controlling Th17-immunity, such that deletion of Nod2 exacerbated experimental autoimmune arthritis and uveitis. Protection against opportunistic Candida albicans infection relies on intact Th1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::611c9161c54233f270574e62d354411e
https://doi.org/10.4049/jimmunol.208.supp.58.08

N-terminal signals in the SNX-BAR paralogs Vps5 and Vin1 guide endosomal coat complex formation.

Autor: Shortill SP; Department of Medical Genetics, University of British Columbia, Vancouver, BC VH6 3N1, Canada.; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada., Frier MS; Department of Medical Genetics, University of British Columbia, Vancouver, BC VH6 3N1, Canada.; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada., Davey M; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada., Conibear E; Department of Medical Genetics, University of British Columbia, Vancouver, BC VH6 3N1, Canada.; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2024 Jun 01; Vol. 35 (6), pp. ar76. Date of Electronic Publication: 2024 Apr 10.

Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution.

Autor: Castro IG; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Shortill SP; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Dziurdzik SK; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Cadou A; Laboratory for Molecular Cell Biology, University College London, London, United Kingdom., Ganesan S; Department of Biological Sciences, University of Calgary, Calgary, Canada., Valenti R; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., David Y; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Davey M; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada., Mattes C; Medical Biochemistry and Molecular Biology, PZMS, Medical Faculty, Saarland University, Homburg, Germany., Thomas FB; Laboratory for Molecular Cell Biology, University College London, London, United Kingdom., Avraham RE; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Meyer H; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Fadel A; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Fenech EJ; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Ernst R; Medical Biochemistry and Molecular Biology, PZMS, Medical Faculty, Saarland University, Homburg, Germany., Zaremberg V; Department of Biological Sciences, University of Calgary, Calgary, Canada., Levine TP; UCL Institute of Ophthalmology, University College London, London, United Kingdom., Stefan C; Laboratory for Molecular Cell Biology, University College London, London, United Kingdom., Conibear E; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Schuldiner M; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Publikováno v: ELife [Elife] 2022 Nov 10; Vol. 11. Date of Electronic Publication: 2022 Nov 10.

A VPS13D spastic ataxia mutation disrupts the conserved adaptor-binding site in yeast Vps13.

Autor: Dziurdzik SK; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada., Bean BDM; Department of Biology, Concordia University, Montreal, QC H3G 1M8, Canada., Davey M; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada., Conibear E; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2020 Mar 13; Vol. 29 (4), pp. 635-648.

The chaperone Chs7 forms a stable complex with Chs3 and promotes its activity at the cell surface.

Autor: Dharwada ST; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada., Dalton LE; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada., Bean BDM; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada., Padmanabhan N; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada., Choi C; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada., Schluter C; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada., Davey M; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada., Conibear E; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.

Publikováno v: Traffic (Copenhagen, Denmark) [Traffic] 2018 Apr; Vol. 19 (4), pp. 285-295. Date of Electronic Publication: 2018 Mar 04.