Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Michael M C Lai"'
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006609 (2017)
Hepatitis C virus (HCV) induces autophagy to promote its replication, including its RNA replication, which can take place on double-membrane vesicles known as autophagosomes. However, how HCV induces the biogenesis of autophagosomes and how HCV RNA r
Externí odkaz:
https://doaj.org/article/039572ef52af45f299575274bc6c76ee
Autor:
Chia-Yi Yu, Jian-Jong Liang, Jin-Kun Li, Yi-Ling Lee, Bi-Lan Chang, Chan-I Su, Wei-Jheng Huang, Michael M C Lai, Yi-Ling Lin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005350 (2015)
Mitochondria are highly dynamic subcellular organelles participating in many signaling pathways such as antiviral innate immunity and cell death cascades. Here we found that mitochondrial fusion was impaired in dengue virus (DENV) infected cells. Two
Externí odkaz:
https://doaj.org/article/8b6f978467c64f1e908e22e294a30a92
Autor:
Chao-Kuen Lai, Vikas Saxena, Chung-Hsin Tseng, King-Song Jeng, Michinori Kohara, Michael M C Lai
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99022 (2014)
Nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) serves dual functions in viral RNA replication and virus assembly. Here, we demonstrate that HCV replication complex along with NS5A and Core protein was transported to the lipid droplet (LD)
Externí odkaz:
https://doaj.org/article/a862cbf962884688b8005a3ba4743feb
Autor:
Yasuteru Kondo, Masashi Ninomiya, Osamu Kimura, Keigo Machida, Ryo Funayama, Takeshi Nagashima, Koju Kobayashi, Eiji Kakazu, Takanobu Kato, Keiko Nakayama, Michael M C Lai, Tooru Shimosegawa
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98521 (2014)
Various kinds of autoimmune diseases have been reported to have a significant relationship with persistent hepatitis c virus (HCV) infection and Th17 cells. Previously, our group reported that the existence of HCV in T lymphocytes could affect the de
Externí odkaz:
https://doaj.org/article/53c400fd0106417283a5f2c61a01d42c
Publikováno v:
PLoS Pathogens, Vol 8, Iss 6, p e1002766 (2012)
For Hepatitis C virus (HCV), initiation of translation is cap-independently mediated by its internal ribosome entry site (IRES). Unlike other IRES-containing viruses that shut off host cap-dependent translation, translation of HCV coexists with that
Externí odkaz:
https://doaj.org/article/36f9ad27b6f14032ad4c6c7f57925acc
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43600 (2012)
Hepatitis C virus (HCV) RNA initiates its replication on a detergent-resistant membrane structure derived from the endoplasmic reticulum (ER) in the HCV replicon cells. By performing a pulse-chase study of BrU-labeled HCV RNA, we found that the newly
Externí odkaz:
https://doaj.org/article/906f79e9260a4a54a7a3ca501e2949a5
Autor:
Mei-Lin Yang, Yi-Cheng Chen, Chung-Teng Wang, Hao-Earn Chong, Nai-Hui Chung, Chia-Hsing Leu, Fu-Tong Liu, Michael M. C. Lai, Pin Ling, Chao-Liang Wu, Ai-Li Shiau
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-22 (2023)
Abstract Background Influenza is one of the most important viral infections globally. Viral RNA-dependent RNA polymerase (RdRp) consists of the PA, PB1, and PB2 subunits, and the amino acid residues of each subunit are highly conserved among influenz
Externí odkaz:
https://doaj.org/article/8201530a06c646baba7c06ffdd648f2d
Autor:
Ivonne Melano, Wei-Chung Cheng, Li-Lan Kuo, Yuag-Meng Liu, Yu Chi Chou, Mien-Chie Hung, Michael M. C. Lai, Yuh-Pyng Sher, Wen-Chi Su
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus disease-19 (COVID-19) pandemic, utilizes angiotensin-converting enzyme 2 (ACE2) as a receptor for virus infection. However, the expression
Externí odkaz:
https://doaj.org/article/019f88b4e76647a19ada77ea39f4d35e
Autor:
Hsin-I Wang, Zih-Shiuan Chuang, Yu-Ting Kao, Yi-Ling Lin, Jian-Jong Liang, Chun-Che Liao, Ching-Len Liao, Michael M. C. Lai, Chia-Yi Yu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 9087 (2021)
The SARS-CoV-2 pseudovirus is a commonly used strategy that mimics certain biological functions of the authentic virus by relying on biological legitimacy at the molecular level. Despite the fact that spike (S), envelope (E), and membrane (M) protein
Externí odkaz:
https://doaj.org/article/a3dd9a4df3fb4e8c8ffeb1ddb7508ba6
Autor:
Chia-Yin Ho, Wen-Chi Su, Yi-Chun Chen, Meng-Yen Ho, Wen-Ya Yu, Michael M. C. Lai, Yuag-Meng Liu, Hui-Chen Chen
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases
Emerging evidence highlights the role of non-coding small RNAs in host-influenza interaction. We have identified a Y RNA-derived small RNA, miR-1975, which is upregulated upon influenza A virus infection in A549 cells. The aim of this study is to inv