Zobrazeno 1 - 10
of 352
pro vyhledávání: '"Michael M C Lai"'
Autor:
Ivonne Melano, Wei-Chung Cheng, Li-Lan Kuo, Yuag-Meng Liu, Yu Chi Chou, Mien-Chie Hung, Michael M. C. Lai, Yuh-Pyng Sher, Wen-Chi Su
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus disease-19 (COVID-19) pandemic, utilizes angiotensin-converting enzyme 2 (ACE2) as a receptor for virus infection. However, the expression
Externí odkaz:
https://doaj.org/article/019f88b4e76647a19ada77ea39f4d35e
Autor:
Mei-Lin Yang, Yi-Cheng Chen, Chung-Teng Wang, Hao-Earn Chong, Nai-Hui Chung, Chia-Hsing Leu, Fu-Tong Liu, Michael M. C. Lai, Pin Ling, Chao-Liang Wu, Ai-Li Shiau
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-22 (2023)
Abstract Background Influenza is one of the most important viral infections globally. Viral RNA-dependent RNA polymerase (RdRp) consists of the PA, PB1, and PB2 subunits, and the amino acid residues of each subunit are highly conserved among influenz
Externí odkaz:
https://doaj.org/article/8201530a06c646baba7c06ffdd648f2d
Autor:
Yuag-Meng Liu, Chung-Hsin Tseng, Yi-Chun Chen, Wen-Ya Yu, Meng-Yen Ho, Chia-Yin Ho, Michael M. C. Lai, Wen-Chi Su
Publikováno v:
Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-14 (2019)
Abstract Background Multiple interplays between viral and host factors are involved in influenza virus replication and pathogenesis. Several small RNAs have recently emerged as important regulators of host response to viral infections. The aim of thi
Externí odkaz:
https://doaj.org/article/89f5fbe02ebf469eafaa52af96e7aea1
Autor:
Chia-Lin Chen, Jeffrey Y. Huang, Chun-Hsiang Wang, Stanley M Tahara, Lin Zhou, Yasuteru Kondo, Joel Schechter, Lishan Su, Michael M C. Lai, Takaji Wakita, François-Loïc Cosset, Jae U Jung, Keigo Machida
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Infection of B cells by hepatitis C virus (HCV) is poorly understood, but is thought to result in lymphoproliferative disorders. Here, Chenet al. identify CD86 as co-receptor for lymphotropic HCV and show that HCV infection inhibits memory B-cell fun
Externí odkaz:
https://doaj.org/article/1991ac8957f64473b697653d17ea07e4
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
In the battle between a virus and its host, innate immunity serves as the first line of defense protecting the host against pathogens. The antiviral actions start with the recognition of pathogen-associated molecular patterns derived from the virus,
Externí odkaz:
https://doaj.org/article/18354c210703455fba41bc8b71cf2c30
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006609 (2017)
Hepatitis C virus (HCV) induces autophagy to promote its replication, including its RNA replication, which can take place on double-membrane vesicles known as autophagosomes. However, how HCV induces the biogenesis of autophagosomes and how HCV RNA r
Externí odkaz:
https://doaj.org/article/039572ef52af45f299575274bc6c76ee
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Influenza A virus (IAV) RNA segments are individually packaged with viral nucleoprotein (NP) and RNA polymerases to form a viral ribonucleoprotein (vRNP) complex. We previously reported that NP is a monoubiquitinated protein which can be deu
Externí odkaz:
https://doaj.org/article/79ef6de50d044801bd1ebc872cca3764
Autor:
Chia-Yin Ho, Wen-Chi Su, Yi-Chun Chen, Meng-Yen Ho, Wen-Ya Yu, Michael M. C. Lai, Yuag-Meng Liu, Hui-Chen Chen
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases
Emerging evidence highlights the role of non-coding small RNAs in host-influenza interaction. We have identified a Y RNA-derived small RNA, miR-1975, which is upregulated upon influenza A virus infection in A549 cells. The aim of this study is to inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70995cb34765b33c6cbb1db28ac1497
http://europepmc.org/articles/PMC7437959
http://europepmc.org/articles/PMC7437959
Autor:
Chung-Hsin Tseng, Michael M. C. Lai
Publikováno v:
Viruses, Vol 1, Iss 3, Pp 818-831 (2009)
Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism. Nevertheless, the production of hepatitis delta antigen
Externí odkaz:
https://doaj.org/article/e3b78d961c624134a0cc86da0aadaed8
Autor:
Chia-Yi Yu, Jian-Jong Liang, Jin-Kun Li, Yi-Ling Lee, Bi-Lan Chang, Chan-I Su, Wei-Jheng Huang, Michael M C Lai, Yi-Ling Lin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005350 (2015)
Mitochondria are highly dynamic subcellular organelles participating in many signaling pathways such as antiviral innate immunity and cell death cascades. Here we found that mitochondrial fusion was impaired in dengue virus (DENV) infected cells. Two
Externí odkaz:
https://doaj.org/article/8b6f978467c64f1e908e22e294a30a92