Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Michael M, Seidman"'
Publikováno v:
Cells, Vol 12, Iss 22, p 2607 (2023)
Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand. Replisomes consist of two functional units, a helicase
Externí odkaz:
https://doaj.org/article/9f612cd2da4c4825bd14a071e16b1869
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101610- (2022)
Summary: Telomere dysfunction-induced foci (TIF) can be measured by immunofluorescence, combined with telomere-fluorescent in situ hybridization. We modified this approach by combining the proximity ligation assay (PLA), which detects colocalization
Externí odkaz:
https://doaj.org/article/42c90d29fa3d4d2ba67f719fd535c9ee
Autor:
Jing Zhang, Marina A. Bellani, Ryan C. James, Durga Pokharel, Yongqing Zhang, John J. Reynolds, Gavin S. McNee, Andrew P. Jackson, Grant S. Stewart, Michael M. Seidman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Eukaryotic replisomes are multiprotein complexes. Here the authors reveal two distinct stressed replisomes, associated with DONSON and FANCM, displaying a bias in replication timing and chromatin domain.
Externí odkaz:
https://doaj.org/article/d7a82d16e8a04937bed09a5543ead4cb
Autor:
Nathan Ellis, Jianmei Zhu, Mary K Yagle, Wei-Chih Yang, Jing Huang, Alexander Kwako, Michael M. Seidman, Michael J. Matunis
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Sumoylation is an important enhancer of responses to DNA replication stress and the SUMO-targeted ubiquitin E3 ligase RNF4 regulates these responses by ubiquitylation of sumoylated DNA damage response factors. The specific targets and functional cons
Externí odkaz:
https://doaj.org/article/4b8e2de0c097408e949433f640f984d0
Autor:
Jing Zhang, Marina A. Bellani, Jing Huang, Ryan C. James, Durga Pokharel, Julia Gichimu, Himabindu Gali, Grant Stewart, Michael M. Seidman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Replisomes follow a schedule in which replication of DNA in euchromatin is early in S phase while sequences in heterochromatin replicate late. Impediments to DNA replication, referred to as replication stress, can stall replication forks triggering a
Externí odkaz:
https://doaj.org/article/bbbb56aa032e43b0951f58fbf4559590
Autor:
Douglas E. Brash, Michael M. Seidman
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 5-7 (2020)
Externí odkaz:
https://doaj.org/article/cf26af717d0a471e9d7ba7a0e6f6e6b2
Autor:
Jing Huang, Jing Zhang, Marina A. Bellani, Durga Pokharel, Julia Gichimu, Ryan C. James, Himabindu Gali, Chen Ling, Zhijiang Yan, Dongyi Xu, Junjie Chen, Amom Ruhikanta Meetei, Lei Li, Weidong Wang, Michael M. Seidman
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1794-1808.e5 (2019)
Summary: Eukaryotic replisomes are driven by the mini chromosome maintenance (MCM [M]) helicase complex, an offset ring locked around the template for leading strand synthesis by CDC45 (C) and GINS (G) proteins. Although the CDC45 MCM GINS (CMG) stru
Externí odkaz:
https://doaj.org/article/aaee9a3577bd4fb7b845c27a87340523
Autor:
Tian-Li Wang, Ie-Ming Shih, Vilhelm A. Bohr, Anthony K.L. Leung, Sonia Franco, Michael M. Seidman, Akila Viswanathan, Ayse Ayhan, Stephanie Gaillard, Marina A. Bellani, Raghavendra A. Shamanna, Zheng-Cheng Yu, Yohan Suryo Rahmanto, M. Herman Chui, Youngran Park
In vivo phosphoproteome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff115c43311f2882ecd70309167ade4
https://doi.org/10.1158/1078-0432.22470921.v1
https://doi.org/10.1158/1078-0432.22470921.v1
Autor:
Tian-Li Wang, Ie-Ming Shih, Vilhelm A. Bohr, Anthony K.L. Leung, Sonia Franco, Michael M. Seidman, Akila Viswanathan, Ayse Ayhan, Stephanie Gaillard, Marina A. Bellani, Raghavendra A. Shamanna, Zheng-Cheng Yu, Yohan Suryo Rahmanto, M. Herman Chui, Youngran Park
Supplementary Figures and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4607aa4c24607484d6c4b2b7605f518c
https://doi.org/10.1158/1078-0432.22470924
https://doi.org/10.1158/1078-0432.22470924
Autor:
Amom Ruhikanta Meetei, Michael M. Seidman, Kebola Wahengbam, Arun Pradhan, Manikandan Paramasivam, Abdullah Mahmood Ali, Thiyam Ramsing Singh
Fanconi anemia (FA) is a genome instability syndrome that has been associated with both cancer predisposition and bone marrow failure. FA proteins are involved in cellular response to replication stress in which they coordinate DNA repair with DNA re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e4184fae5977477d041c5a7b84ac3f
https://doi.org/10.1158/0008-5472.c.6504926.v1
https://doi.org/10.1158/0008-5472.c.6504926.v1