Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Michael M, Poon"'
Autor:
Michael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana O. Lorenzana, Bryanna E. Paulson, Christopher S. Baccei, Jeffrey R. Roppe, Thomas O. Schrader, Lino J. Valdez, Yifeng Xiong, Austin C. Chen, Daniel S. Lorrain
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract Multiple sclerosis (MS) is a chronic neurological disease characterized by inflammatory demyelination that disrupts neuronal transmission resulting in neurodegeneration progressive disability. While current treatments focus on immunosuppress
Externí odkaz:
https://doaj.org/article/968e173534244880bfd928cf16265e56
Autor:
Daniel S. Lorrain, Ariana O Lorenzana, Alexander Broadhead, Christopher Baccei, Xiong Yifeng, Thomas O. Schrader, Michael M Poon, Karin J. Stebbins
Publikováno v:
ACS Medicinal Chemistry Letters. 12:155-161
The discovery of PIPE-359, a brain-penetrant and selective antagonist of the muscarinic acetylcholine receptor subtype 1 is described. Starting from a literature-reported M1 antagonist, linker replacement and structure-activity relationship investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::430b568160efae9b410358b8f2bedc3b
https://doi.org/10.1021/acsmedchemlett.0c00626
https://doi.org/10.1021/acsmedchemlett.0c00626
Autor:
Thomas O, Schrader, Yifeng, Xiong, Ariana O, Lorenzana, Alexander, Broadhead, Karin J, Stebbins, Michael M, Poon, Christopher, Baccei, Daniel S, Lorrain
Publikováno v:
ACS Med Chem Lett
[Image: see text] The discovery of PIPE-359, a brain-penetrant and selective antagonist of the muscarinic acetylcholine receptor subtype 1 is described. Starting from a literature-reported M(1) antagonist, linker replacement and structure–activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fa8ec81843f4909dda2e384fce0b703
https://pubmed.ncbi.nlm.nih.gov/33488977
https://pubmed.ncbi.nlm.nih.gov/33488977
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24879 (2011)
Local translation of dendritic mRNAs plays an important role in neuronal development and synaptic plasticity. Although several hundred putative dendritic transcripts have been identified in the hippocampus, relatively few have been verified by in sit
Externí odkaz:
https://doaj.org/article/9a6744b763c148d0b459d3b27f241f3d
Autor:
Michael M. Poon, Lu Chen
Retinoic acid (RA) plays important roles in development by modulating gene transcription through nuclear receptor activation. Increasing evidence supports a role for RA and RA receptors (RARs) in synaptic plasticity in the brain. We have recently rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b238816463b224382fbc3f5836a7bbc
https://europepmc.org/articles/PMC2629326/
https://europepmc.org/articles/PMC2629326/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(41)
Homeostatic plasticity is thought to play an important role in maintaining the stability of neuronal circuits. During one form of homeostatic plasticity, referred to as synaptic scaling, activity blockade leads to a compensatory increase in synaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abeda8b23980a4dfba8d9afd479caeae
https://pubmed.ncbi.nlm.nih.gov/18840692
https://pubmed.ncbi.nlm.nih.gov/18840692
The regulated translation of localized mRNAs in neurons provides a mechanism for spatially restricting gene expression in a synapse-specific manner. To identify the population of mRNAs present in distal neuronal processes of rodent hippocampal neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be82c090cad85046dea2e6b65011fd0c
https://europepmc.org/articles/PMC6675000/
https://europepmc.org/articles/PMC6675000/
Autor:
Richard Bundey, Davorka Messmer, Peppi Prasit, Geraldine Cabrera, Jason D. Jacintho, Yalda Bravo, Michael M Poon, Nicholas Simon Stock, Daniel S. Lorrain, Kymmy Lorrain, Austin Chen, Lucia Correa, Karin J. Stebbins, David Spaner
Publikováno v:
Blood. 120:3879-3879
Abstract 3879 Tumor-specific metabolic changes could serve as new therapeutic targets. While much attention has been given to the metabolism of glucose in cancer cells and intervening therapies, relatively little attention has been given to fatty aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04a1f67444471f465aae6b7e4ca5a1ff
https://doi.org/10.1182/blood.v120.21.3879.3879
https://doi.org/10.1182/blood.v120.21.3879.3879
Autor:
Poon M; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Department of Neurosurgery, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.; Edinburgh Spinal Surgery Outcome Studies Group, Edinburgh, United Kingdom., Georgiopoulos M; Spinal Surgical Unit, Trauma and Orthopaedics, Swansea Bay University Health Board, Swansea, United Kingdom., Lasry O; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Chalk C; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Demetriades AK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Department of Neurosurgery, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.; Edinburgh Spinal Surgery Outcome Studies Group, Edinburgh, United Kingdom.
Publikováno v:
Frontiers in neurology [Front Neurol] 2024 Sep 03; Vol. 15, pp. 1468613. Date of Electronic Publication: 2024 Sep 03 (Print Publication: 2024).