Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Michael M, Poe"'
Autor:
Lalit K. Golani, Donna M. Platt, Daniela Rüedi-Bettschen, Chitra Edwanker, Shenming Huang, Michael M. Poe, Roman Furtmüller, Werner Sieghart, James M. Cook, James K. Rowlett
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
In order to develop improved anxiolytic drugs, 8-substituted analogs of triazolam were synthesized in an effort to discover compounds with selectivity for α2/α3 subunit-containing GABAA subtypes. Two compounds in this series, XLi-JY-DMH (6-(2-chlor
Externí odkaz:
https://doaj.org/article/a95252a7ff224cdca9d223b58e02c490
Autor:
Guanguan Li, Michael R. Stephen, Revathi Kodali, Nicolas M. Zahn, Michael M. Poe, V. V. N. Phani Babu Tiruveedhula, Alec T. Huber, Melissa K. Schussman, Krista Qualmann, Cristina M. Panhans, Nicholas J. Raddatz, David A. Baker, Thomas D. Prevot, Mounira Banasr, Etienne Sibille, Leggy A. Arnold, James M. Cook
Publikováno v:
ARKIVOC, Vol 2018, Iss 4, Pp 158-182 (2018)
Externí odkaz:
https://doaj.org/article/f6c4d0576c1d4e9fab7e1fad18c61994
Autor:
Guanguan Li, Amanda N. Nieman, Md Yeunus Mian, Nicolas M. Zahn, Brandon N. Mikulsky, Michael M. Poe, Kashi R. Methuku, Yongfeng Liu, James M. Cook, Douglas C. Stafford, Leggy A. Arnold
Publikováno v:
Molecules, Vol 25, Iss 17, p 3864 (2020)
Analgesic and anti-inflammatory properties mediated by the κ opioid receptor (KOR) have been reported for oxadiazole imidazodiazepines. Affinities determined by radioligand competition assays of more than seventy imidazodiazepines using cell homogen
Externí odkaz:
https://doaj.org/article/df69adecaff8428ea34ea1acbb5c2c98
Autor:
Bradford D. Fischer, Thomas M. Keck, Dishary Sharmin, Michael M. Poe, Mohammad Atiqur Rahman, James M. Cook
Publikováno v:
Psychopharmacology. 238:1585-1592
Opioid and GABAA receptors are both located in central nociceptive pathways, and compounds that activate these receptors have pain-relieving properties. To date, the interactive effects of concurrent administration of these compounds in preclinical m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4067fda66371a2a0b47e17c3cacc1adf
https://doi.org/10.1007/s00213-021-05791-1
https://doi.org/10.1007/s00213-021-05791-1
Autor:
Sara Uribe, Eric J. DiDomenico, Christa M. Donegan, Yulista Tapia, Jason Conviser, Rohit R. Nambiar, Amy A. Juarez, Christine M. Side, Danya Aldaghma, Michael M. Poe, Dishary Sharmin, James M. Cook, Thomas M. Keck, Bradford D. Fischer
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::342acca040bd269f77a0ebda57d4fd69
https://doi.org/10.1096/fasebj.2022.36.s1.r5946
https://doi.org/10.1096/fasebj.2022.36.s1.r5946
Autor:
Sean C. Piantadosi, Beverly J French, Michael M Poe, Tamara Timić, Bojan Marković, Mohan Pabba, Marianne Seney, Hyunjung Oh, Beverley Anne Orser, Miroslav M Savic, James M Cook, Etienne Sibille
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Rationale: Current first-line treatments for stress-related disorders such as Major Depressive Disorder (MDD) act on monoaminergic systems and take weeks to achieve a therapeutic effect with poor response and low remission rates. Recent research has
Externí odkaz:
https://doaj.org/article/515c507b61a84f9b9e34801b34d2a83d
Autor:
Nyema M. Harmon, Michael M. Poe, Xueting Huang, Rohit Singh, Benjamin J. Foust, Chia-Hung Christine Hsiao, David F. Wiemer, Andrew J. Wiemer
Publikováno v:
ACS Med Chem Lett
[Image: see text] Phosphoantigens (pAgs) are small organophosphorus compounds such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) that trigger an immune response. These molecules bind to butyrophilin 3A1 (part of the HMBPP receptor) and act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be1bd47114c540b084383d367d85509
https://pubmed.ncbi.nlm.nih.gov/35178171
https://pubmed.ncbi.nlm.nih.gov/35178171
Publikováno v:
Cell Death and Disease, Vol 10, Iss 10, Pp 1-12 (2019)
Cell Death & Disease
Cell Death & Disease
Notch proteins drive oncogenesis of many cancers, most prominently T-cell acute lymphoblastic leukemia (T-ALL). Because geranylgeranylated Rab proteins regulate Notch processing, we hypothesized that inhibition of geranylgeranyl diphosphate synthase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7f1297a6de7ec822bbfcfff4646675
http://link.springer.com/article/10.1038/s41419-019-1973-7
http://link.springer.com/article/10.1038/s41419-019-1973-7
Autor:
Kelly A. Teske, Andrew J. Wiemer, Sherry S Agabiti, Chia-Hung Christine Hsiao, Michael M. Poe, Caroline Liu, Victoria Li
Publikováno v:
J Med Chem
Small-molecule phosphoantigens such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate stimulate human Vγ9Vδ2 T cells after binding to the intracellular B30.2 domain of the immune receptor butyrophilin 3 isoform A1 (BTN3A1). To understand the ligand-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffc2049e633ff6a4b095bccc46f3569
https://doi.org/10.1021/acs.jmedchem.9b00825
https://doi.org/10.1021/acs.jmedchem.9b00825
Autor:
Bradford D. Fischer, Dishary Sharmin, Michael M. Poe, Mohammad Shafiur Rahman, Thomas M. Keck, James M. Cook
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b73137f0dd9960fbc28891fcb4dc3ac
https://doi.org/10.1096/fasebj.2021.35.s1.03252
https://doi.org/10.1096/fasebj.2021.35.s1.03252