FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

Autor: Adam J. Mead, Shabnam Kharazi, Deborah Atkinson, Iain Macaulay, Christian Pecquet, Stephen Loughran, Michael Lutteropp, Petter Woll, Onima Chowdhury, Sidinh Luc, Natalija Buza-Vidas, Helen Ferry, Sally-Ann Clark, Nicolas Goardon, Paresh Vyas, Stefan N. Constantinescu, Ewa Sitnicka, Claus Nerlov, Sten Eirik W. Jacobsen

Publikováno v: Cell Reports, Vol 3, Iss 6, Pp 1766-1776 (2013)

Whether signals mediated via growth factor receptors (GFRs) might influence lineage fate in multipotent progenitors (MPPs) is unclear. We explored this issue in a mouse knockin model of gain-of-function Flt3-ITD mutation because FLT3-ITDs are paradox

Externí odkaz: https://doaj.org/article/703445d2063749ebb29c59b6e36d5091

Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule

Autor: Natalia Grinberg, Benno Rattel, Natalie F. Mariano, Christoph Dahlhoff, Franziska Vogel, Claudia Bluemel, Famke Aeffner, Petra Deegen, Matthias Friedrich, Michael Lutteropp, Julie M. Bailis, Angela Coxon, Elizabeth Pham, Christian Brandl, John M. Harrold

Publikováno v: Molecular cancer therapeutics. 20(10)

MUC12 is a transmembrane mucin that is highly expressed in >50% of primary and metastatic colorectal tumors. MUC12 is also expressed by normal epithelial cells of the colon and small intestine. Although MUC12 localization in normal epithelial cells i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1394e15449afef2a83378cd7be0157
https://pubmed.ncbi.nlm.nih.gov/34376583

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

Autor: Tiago C. Luis, Hanane Boukarabila, Adam J. Mead, Harsh J. Vaidya, Isabelle Godin, Charlotta Böiers, Rickard Sandberg, Tiphaine Bouriez-Jones, Supat Thongjuea, Alice Giustacchini, Roger Patient, Sidinh Luc, Joana Carrelha, Frederic Geissmann, Marella F. T. R. de Bruijn, Sten Eirik W. Jacobsen, Petter S. Woll, C. Clare Blackburn, Deborah Atkinson, Emanuele Azzoni, Michael Lutteropp, Takuo Mizukami, Claus Nerlov, Iain C. Macaulay

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2016, 17, pp.1424-1435. ⟨10.1038/ni.3576⟩
Luis, T C, Luc, S, Mizukami, T, Boukarabila, H, Thongjuea, S, Woll, P S, Azzoni, E, Giustacchini, A, Lutteropp, M, Bouriez-Jones, T, Vaidya, H, Mead, A J, Atkinson, D, Böiers, C, Carrelha, J, Macaulay, I C, Patient, R, Geissmann, F, Nerlov, C, Sandberg, R, de Bruijn, M F T R, Blackburn, C, Godin, I & Jacobsen, S E W 2016, ' Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors ', Nature Immunology, vol. 17, no. 12, pp. 1424-1437 . https://doi.org/10.1038/ni.3576

The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f69e224fdc8976c991c4ecd4601d0e5
https://doi.org/10.1038/ni.3576

Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells

Autor: Christina Jensen, Marella F. T. R. de Bruijn, Ewa Sitnicka, Adam J. Mead, Elisa Gomez Perdiguero, Shabnam Kharazi, Qiaolin Deng, Deborah Atkinson, Frederic Geissmann, Luca Melchiori, Anne Hultquist, Iain C. Macaulay, Emanuele Azzoni, Joana Carrelha, Sidinh Luc, Annica Pontén, Joanna C. A. Green, Sten Eirik W. Jacobsen, Isabelle Godin, Tiphaine Bouriez-Jones, Tiago C. Luis, Petter S. Woll, Michael Lutteropp, Rickard Sandberg, Gemma Swiers, Charlotta Böiers

Publikováno v: Cell Stem Cell
Cell Stem Cell, Cambridge, MA : Cell Press, 2013, 13 (5), pp.535-548. ⟨10.1016/j.stem.2013.08.012⟩
Scopus-Elsevier
BASE-Bielefeld Academic Search Engine

In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdd0e028c64c42160d3dd91441f8ed5
https://doi.org/10.1016/j.stem.2013.08.012

Distinct myeloid progenitor differentiation pathways identified through single cell RNA sequencing

Autor: Supat Thongjuea, Adam J. Mead, Ewa Sitnicka, Roy Drissen, Alice Giustacchini, Natalija Buza-Vidas, Adriana Gambardella, Elena Mancini, Claus Nerlov, Alya Zriwil, Petter S. Woll, Amit Grover, Michael Lutteropp, Sten Eirik W. Jacobsen

Publikováno v: Nature immunology

According to current models for hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs; Lin– Sca-1+ c-Kit+ CD34+ Flt3hi) and common myeloid progenitors (CMPs; Lin– Sca- 1+ c-Kit+ CD34+ CD41hi) establish an early branch point for separate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5245e212c475330e30f3644f321fac22
http://ora.ox.ac.uk/objects/uuid:e1797030-960b-452e-9334-5f8194e369e8