Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Michael Linn"'
Autor:
Kathryn Packman, Lyubomir Vassilev, David Heimbrook, Christophe Meille, Michael Linn, Rosario Garrido, Violeta Adames, Shahid Tannu, Kenneth Kolinsky, Edmund Lee, Sazzad Hussain, Zoran Filipovic, Christian Tovar, Antje Walz, Kelli Glenn, Brian Higgins
PDF file - 311KB, Table S1. Results of proliferation assay. Table S2. Estimated PKPD population parameters. Fig. S1. Schematic view of the PK/PD model. Fig S2. Observed PK parameter and model predicted. Fig S3. Visual predictive check.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03937509c03c999ff11b402c64c3a3e1
https://doi.org/10.1158/1078-0432.22456187
https://doi.org/10.1158/1078-0432.22456187
Autor:
Kathryn Packman, Lyubomir Vassilev, David Heimbrook, Christophe Meille, Michael Linn, Rosario Garrido, Violeta Adames, Shahid Tannu, Kenneth Kolinsky, Edmund Lee, Sazzad Hussain, Zoran Filipovic, Christian Tovar, Antje Walz, Kelli Glenn, Brian Higgins
Purpose: Antitumor clinical activity has been demonstrated for the MDM2 antagonist RG7112, but patient tolerability for the necessary daily dosing was poor. Here, utilizing RG7388, a second-generation nutlin with superior selectivity and potency, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b1e546610afd48a3c935087a456191
https://doi.org/10.1158/1078-0432.c.6523232.v1
https://doi.org/10.1158/1078-0432.c.6523232.v1
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 71K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1e12a2827bef15e4c7f52b8f26d01a
https://doi.org/10.1158/0008-5472.22398773.v1
https://doi.org/10.1158/0008-5472.22398773.v1
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 12K, Antitumor activity of RG7112 against a panel of solid tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9c982ff418c10759c503fddf33cbb1
https://doi.org/10.1158/0008-5472.22398764.v1
https://doi.org/10.1158/0008-5472.22398764.v1
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 1272K, Comparison of MDM2 binding properties of RG7112 and nutlin-3a (S1); Overlay of the crystal structures of MDM2 bound to RG7112 and Nutlin-2 (S2); RG7112 is a non-genotoxic p53 activator (S3); Effect of RG7112 on the viability of HCT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed0ac5a589251b018ba5a026af7a98e
https://doi.org/10.1158/0008-5472.22398770
https://doi.org/10.1158/0008-5472.22398770
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 136K, Includes HTRF, cell growth/viability, apoptosis assays and biacore, crystal structure and animal studies. Also includes supplemental references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462335161b3d3a7a48af64749143adb9
https://doi.org/10.1158/0008-5472.22398767.v1
https://doi.org/10.1158/0008-5472.22398767.v1
Autor:
John F. Boylan, David Heimbrook, Kelli Glenn, Helmut Jacobsen, Roland Jakob-Røtne, Alexander Flohr, Michael Linn, Holly Hilton, Windy Berkofsky-Fessler, James Cai, John Roberts, Daisy Carvajal, Maria Vilenchik, Kathryn Packman, Melissa Smith, Wei He, Leopoldo Luistro
Supplementary Methods and Materials from Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f83d7f21ed746ea9de9d9e721b1ff51
https://doi.org/10.1158/0008-5472.22382880
https://doi.org/10.1158/0008-5472.22382880
Autor:
John F. Boylan, David Heimbrook, Kelli Glenn, Helmut Jacobsen, Roland Jakob-Røtne, Alexander Flohr, Michael Linn, Holly Hilton, Windy Berkofsky-Fessler, James Cai, John Roberts, Daisy Carvajal, Maria Vilenchik, Kathryn Packman, Melissa Smith, Wei He, Leopoldo Luistro
Supplementary Figure 2 from Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521897168f201bde5991eb3d55c7b264
https://doi.org/10.1158/0008-5472.22382883.v1
https://doi.org/10.1158/0008-5472.22382883.v1
Autor:
John F. Boylan, David Heimbrook, Kelli Glenn, Helmut Jacobsen, Roland Jakob-Røtne, Alexander Flohr, Michael Linn, Holly Hilton, Windy Berkofsky-Fessler, James Cai, John Roberts, Daisy Carvajal, Maria Vilenchik, Kathryn Packman, Melissa Smith, Wei He, Leopoldo Luistro
Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of γ-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b590f8f74623298092a9047a0367925c
https://doi.org/10.1158/0008-5472.c.6500352
https://doi.org/10.1158/0008-5472.c.6500352
Autor:
Valeria Pessei, Marco Macagno, Elisa Mariella, Noemi Congiusta, Vittorio Battaglieri, Paolo Battuello, Marco Viviani, Giulia Gionfriddo, Simona Lamba, Annalisa Lorenzato, Daniele Oddo, Fariha Idrees, Alessandro Cavaliere, Alice Bartolini, Simonetta Guarrera, Michael Linnebacher, Laura Monteonofrio, Luca Cardone, Michele Milella, Andrea Bertotti, Silvia Soddu, Elena Grassi, Giovanni Crisafulli, Alberto Bardelli, Ludovic Barault, Federica Di Nicolantonio
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Liquid biopsy based on cell-free DNA (cfDNA) analysis holds significant promise as a minimally invasive approach for the diagnosis, genotyping, and monitoring of solid malignancies. Human tumors release cfDNA in the bloodstream th
Externí odkaz:
https://doaj.org/article/769e6f9e67d94058a19f60e264b16a42
