Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael Lie-A-Ling"'
SGOL1-AS1 enhances cell survival in acute myeloid leukemia by maintaining pro-inflammatory signaling
Autor:
Ewan Selkirk, Rahima Patel, Anna Hoyle, Michael Lie-a-Ling, Duncan Smith, Joe Swift, Georges Lacaud
Publikováno v:
Heliyon, Vol 8, Iss 11, Pp e11362- (2022)
Epigenetic dysregulation is a key feature of most acute myeloid leukemia (AML). Recently, it has become clear that long noncoding RNAs (lncRNAs) can play a key role in epigenetic regulation, and consequently also dysregulation. Currently, our underst
Externí odkaz:
https://doaj.org/article/200fb99b57a4430ab65fcfda11acbdb0
Autor:
Hélène Jakobczyk, Lydie Debaize, Benoit Soubise, Stéphane Avner, Jérémie Rouger-Gaudichon, Séverine Commet, Yan Jiang, Aurélien A. Sérandour, Anne-Gaëlle Rio, Jason S. Carroll, Christian Wichmann, Michael Lie-a-Ling, Georges Lacaud, Laurent Corcos, Gilles Salbert, Marie-Dominique Galibert, Virginie Gandemer, Marie-Bérengère Troadec
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-17 (2021)
Abstract Background B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) is the most common pediatric cancer. Identifying key players involved in proliferation of BCP-ALL cells is crucial to propose new therapeutic targets. Runt Related Transcript
Externí odkaz:
https://doaj.org/article/3e5be24cee0f4d4db6d0258b58f9a08b
Autor:
Sara Menegatti, Bethany Potts, Eva Garcia-Alegria, Roberto Paredes, Michael Lie-A-Ling, Georges Lacaud, Valerie Kouskoff
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The transcription factor RUNX1 is a master regulator of blood cell specification. During embryogenesis, hematopoietic progenitors are initially generated from hemogenic endothelium through an endothelium-to-hematopoietic transition controlled by RUNX
Externí odkaz:
https://doaj.org/article/a6f8d5f00ead4d83b87a2eb947b00fef
Autor:
Fabrizio Simeoni, Isabel Romero-Camarero, Francesco Camera, Fabio M.R. Amaral, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Michael Lie-A-Ling, Georges Lacaud, Daniel H. Wiseman, Jason S. Carroll, Tim C.P. Somervaille
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109725- (2021)
Summary: Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXAhigh acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophag
Externí odkaz:
https://doaj.org/article/03d3a10c03eb467b9558377392816f96
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
During ontogeny, the establishment of the hematopoietic system takes place in several phases, separated both in time and location. The process is initiated extra-embryonically in the yolk sac (YS) and concludes in the main arteries of the embryo with
Externí odkaz:
https://doaj.org/article/6ded0f78658d4d19b17adb8d30d62da4
Autor:
M S Vijayabaskar, Debbie K Goode, Nadine Obier, Monika Lichtinger, Amber M L Emmett, Fatin N Zainul Abidin, Nisar Shar, Rebecca Hannah, Salam A Assi, Michael Lie-A-Ling, Berthold Gottgens, Georges Lacaud, Valerie Kouskoff, Constanze Bonifer, David R Westhead
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007337 (2019)
Gene expression governs cell fate, and is regulated via a complex interplay of transcription factors and molecules that change chromatin structure. Advances in sequencing-based assays have enabled investigation of these processes genome-wide, leading
Externí odkaz:
https://doaj.org/article/ce48b7160bf8439990c2092f2e79e3da
Publikováno v:
Stem Cell Research, Vol 12, Iss 1, Pp 222-232 (2014)
Vascular smooth muscle cells represent a major component of the cardiovascular system. In vitro studies have shown that FLK1+ cells derived from embryonic stem (ES) cells can differentiate into both endothelial and smooth muscle cells. These FLK1+ ce
Externí odkaz:
https://doaj.org/article/467af8bb021240a7a9490bf7f1c7e413
Autor:
Georges Lacaud, Pierre Savatier, Renaud Mevel, Syed Murtuza Baker, Irene Aksoy, Wen Hao Neo, Rahima Patel, Valerie Kouskoff, Magnus Rattray, Laura Fontenille, Roshana Thambyrajah, Nam Do Khoa, Muhammad Zaki Hidayatullah Fadlullah, Michael Lie-A-Ling
Publikováno v:
Fadlullah, M Z H, Neo, W H, Lie-a-ling, M, Thambyrajah, R, Patel, R, Mevel, R, Aksoy, I, Do Khoa, N, Savatier, P, Fontenille, L, Baker, S M, Rattray, M, Kouskoff, V & Lacaud, G 2022, ' Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE ', Blood, vol. 139, no. 3, pp. 343-356 . https://doi.org/10.1182/blood.2020007885, https://doi.org/10.1182/blood.2020007885
In vitro generation and expansion of hematopoietic stem cells (HSCs) holds great promise for the treatment of any ailment that relies on bone marrow or blood transplantation. To achieve this, it is essential to resolve the molecular and cellular path
Autor:
Georges Lacaud, Jason S. Carroll, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Daniel H. Wiseman, Isabel Romero-Camarero, Tim C. P. Somervaille, Francesco Camera, Fabio M. R. Amaral, Fabrizio Simeoni, Michael Lie-A-Ling
Publikováno v:
Cell Reports
Cell Reports, Vol 36, Iss 12, Pp 109725-(2021)
Cell Reports, Vol 36, Iss 12, Pp 109725-(2021)
Summary Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXAhigh acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophage
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
During ontogeny, the establishment of the hematopoietic system takes place in several phases, separated both in time and location. The process is initiated extra-embryonically in the yolk sac (YS) and concludes in the main arteries of the embryo with