Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Michael Lidschreiber"'
Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells
Autor:
Le Xiong, Erik A Tolen, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler
Publikováno v:
eLife, Vol 11 (2022)
The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not fully understood. Here, we investigate the functions of Oct4 by depleting and subsequently recovering it in mouse
Externí odkaz:
https://doaj.org/article/1d5965331e63415ea1891c5a5bf6e818
Autor:
Rui Shao, Banushree Kumar, Katja Lidschreiber, Michael Lidschreiber, Patrick Cramer, Simon J Elsässer
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 1, Pp n/a-n/a (2022)
Abstract Mouse embryonic stem cells (mESCs) can adopt naïve, ground, and paused pluripotent states that give rise to unique transcriptomes. Here, we use transient transcriptome sequencing (TT‐seq) to define both coding and non‐coding transcripti
Externí odkaz:
https://doaj.org/article/2de88ef7f29d4451b293ebf8ca0516d6
Autor:
Gert-Jan Hendriks, Lisa A. Jung, Anton J. M. Larsson, Michael Lidschreiber, Oscar Andersson Forsman, Katja Lidschreiber, Patrick Cramer, Rickard Sandberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Sequencing of newly synthesised RNA can reveal the transcriptional dynamics in a population of cells. Here the authors develop NASC-seq to bring this sensitivity and temporal resolution to single-cell analysis.
Externí odkaz:
https://doaj.org/article/6c2539c49151440bae8f5d6aea33b041
Autor:
Katja Lidschreiber, Lisa A Jung, Henrik von derEmde, Kashyap Dave, Jussi Taipale, Patrick Cramer, Michael Lidschreiber
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 1, Pp n/a-n/a (2021)
Abstract The growth of human cancer cells is driven by aberrant enhancer and gene transcription activity. Here, we use transient transcriptome sequencing (TT‐seq) to map thousands of transcriptionally active putative enhancers in fourteen human can
Externí odkaz:
https://doaj.org/article/f9845d94031942ae8a720cdf29e6f3fa
Autor:
Sofia Battaglia, Michael Lidschreiber, Carlo Baejen, Phillipp Torkler, Seychelle M Vos, Patrick Cramer
Publikováno v:
eLife, Vol 6 (2017)
For transcription through chromatin, RNA polymerase (Pol) II associates with elongation factors (EFs). Here we show that many EFs crosslink to RNA emerging from transcribing Pol II in the yeast Saccharomyces cerevisiae. Most EFs crosslink preferentia
Externí odkaz:
https://doaj.org/article/e7db3bfd4b324548acadfae3d2e47a88
Autor:
Alexandra-Viola Bohne, Christian Schwarz, Marco Schottkowski, Michael Lidschreiber, Markus Piotrowski, William Zerges, Jörg Nickelsen
Publikováno v:
PLoS Biology, Vol 11, Iss 2, p e1001482 (2013)
Metabolic control of gene expression coordinates the levels of specific gene products to meet cellular demand for their activities. This control can be exerted by metabolites acting as regulatory signals and/or a class of metabolic enzymes with dual
Externí odkaz:
https://doaj.org/article/5f216a7276b04e6f824fde8327e40078
Autor:
Lisa Marcinowski, Michael Lidschreiber, Lukas Windhager, Martina Rieder, Jens B Bosse, Bernd Rädle, Thomas Bonfert, Ildiko Györy, Miranda de Graaf, Olivia Prazeres da Costa, Philip Rosenstiel, Caroline C Friedel, Ralf Zimmer, Zsolt Ruzsics, Lars Dölken
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002908 (2012)
During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the rea
Externí odkaz:
https://doaj.org/article/26bea85d59a24b618eaf3a8c6d163a79
Autor:
Theresa Niederberger, Stefanie Etzold, Michael Lidschreiber, Kerstin C Maier, Dietmar E Martin, Holger Fröhlich, Patrick Cramer, Achim Tresch
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 6, p e1002568 (2012)
The Mediator is a highly conserved, large multiprotein complex that is involved essentially in the regulation of eukaryotic mRNA transcription. It acts as a general transcription factor by integrating regulatory signals from gene-specific activators
Externí odkaz:
https://doaj.org/article/dd20bb50e6d840f99cb48e1863c7201b
Autor:
Julio Abril-Garrido, Christian Dienemann, Frauke Grabbe, Taras Velychko, Michael Lidschreiber, Haibo Wang, Patrick Cramer
Publikováno v:
Molecular Cell.
Autor:
Erik A Tolen, Le Xiong, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca9e19f99e30a5e867714e090f2dbfe3
https://doi.org/10.7554/elife.71533.sa2
https://doi.org/10.7554/elife.71533.sa2