Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Michael Lesslie"'
Autor:
Cheryl Martin, Yelizaveta Babayan, Chaitanya S. Wannere, Donnie Pulliam, Fenghe Qiu, Ping Zhuang, Jin Wang, Michael Lesslie, Pat Forenzo, Lars Gruenig, Megan McMahon, Susan Smith, Cherokee Hoaglund-Hyzer, Brian P. Regler, Eric Adamec
Publikováno v:
Journal of Pharmaceutical Innovation. 17:856-866
Purpose This paper summarizes results from a recent pharmaceutical industry survey to understand the adoption status of science- and risk-based approaches in pharmaceutical stability (lean stability) in regulatory submissions across the full pharmace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e4b345bb35f8781ec0f1369c176fabe
https://doi.org/10.1007/s12247-021-09540-x
https://doi.org/10.1007/s12247-021-09540-x
Autor:
Cherokee S. Hoaglund Hyzer, Bruno Catacchio, Donnie Pulliam, Mingkun Fu, Chait Wannere, Yelizaveta Babayan, Allison L. Dill, Eric Adamec, Megan McMahon, Fenghe Qiu, Angela Coon, Robert Timpano, Lars Gruenig, Karina Szymulanska-Ramamurthy, Michael Lesslie, Brian P. Regler
Publikováno v:
Journal of Pharmaceutical Innovation. 16:566-574
Purpose Lean stability is a science- and risk-based initiative which utilizes the enhanced understanding of drug substance and drug product physical and chemical characteristics to (1) reduce and optimize the design of standard stability protocols; (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4437b626ad512d2419274099ad60dd05
https://doi.org/10.1007/s12247-020-09463-z
https://doi.org/10.1007/s12247-020-09463-z
Autor:
Alan C. Hopkinson, John T. Lawler, Justin Kai-Chi Lau, Michael Lesslie, K. W. Michael Siu, Gardenia Pacheco, Victor Ryzhov
Publikováno v:
International Journal of Mass Spectrometry. 429:39-46
Isomerization of the glutathione thiyl radical via hydrogen atom transfer (HAT) in its complexes with various singly and doubly charged metal ions was studied both experimentally and computationally. The glutathione thiyl radical/metal ion complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0c9dce7081d1d83968866cb0cc2b979
https://doi.org/10.1016/j.ijms.2017.04.012
https://doi.org/10.1016/j.ijms.2017.04.012
Autor:
Daniel Bím, John T. Lawler, Christopher J. Shaffer, Michael Lesslie, Andy Dang, František Tureček, Victor Ryzhov
Publikováno v:
The Journal of Physical Chemistry A. 122:2069-2078
(2,2′-Bipyridine)M═O+ ions (M = Cu, Ni, Co) were generated by collision-induced dissociation and near-UV photodissociation of readily available [(2,2′-bipyridine)MII(NO3)]+ ions in the gas phase, and their structure was confirmed by ion–molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1126d1fced1fca1dfa36e0f6c27d54dd
https://doi.org/10.1021/acs.jpca.7b12445
https://doi.org/10.1021/acs.jpca.7b12445
Autor:
Victor Ryzhov, Allan J. Canty, Francis Berthias, Yang Yang, Philippe Maître, Richard A. J. O'Hair, Michael Lesslie, Elettra L. Piacentino
Publikováno v:
Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2018, 54 (4), pp.346-349. ⟨10.1039/c7cc08944a⟩
Chemical Communications, Royal Society of Chemistry, 2018, 54 (4), pp.346-349. ⟨10.1039/c7cc08944a⟩
A new decarbonylation reaction is observed for [(K2-acetate)Pd(K2-diphosphine)]+ complexes. Gas-phase IR experiments identify the product as [CH3Pd(OP(Ph2)CH2PPh2)]+. DFT calculations uncovered a plausible mechanism involving O atom abstraction by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e1712ceec1dad82d75389a6400f28a
https://doi.org/10.1039/c7cc08944a
https://doi.org/10.1039/c7cc08944a
Autor:
Kai Zhu, Ye Yang, Jue Gong, Richard D. Schaller, Baibiao Huang, Tao Xu, Gang Liu, Ying Dai, Mengjin Yang, Xiangchao Ma, Michael Lesslie, Matthew C. Beard, Lingping Kong
Publikováno v:
The Journal of Physical Chemistry Letters. 7:2879-2887
We report on the carrier-rotor coupling effect in perovskite organic-inorganic hybrid lead iodide (CH3NH3PbI3) compounds discovered by isotope effects. Deuterated organic-inorganic perovskite compounds including CH3ND3PbI3, CD3NH3PbI3, and CD3ND3PbI3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfefe30685ef78e50ff554b0c523d211
https://doi.org/10.1021/acs.jpclett.6b01199
https://doi.org/10.1021/acs.jpclett.6b01199
Autor:
Vincent Steinmetz, Philippe Maître, John T. Lawler, Justin Kai-Chi Lau, Alan C. Hopkinson, Michael Lesslie, K. W. Michael Siu, Victor Ryzhov
Publikováno v:
ChemPlusChem. 81:444-452
The formation and investigation of sulfur-based cysteine radicals cationized by a group 1A metal ion or Ag+ in the gas phase are reported. Gas-phase ion-molecule reactions (IMR) and infrared multiple-photon dissociation (IRMPD) spectroscopy revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c594a94c397f3ba2e9a83af947c32c3
https://doi.org/10.1002/cplu.201500558
https://doi.org/10.1002/cplu.201500558
Autor:
Michael, Lesslie, Yang, Yang, Allan J, Canty, Elettra, Piacentino, Francis, Berthias, Philippe, Maitre, Victor, Ryzhov, Richard A J, O'Hair
Publikováno v:
Chemical communications (Cambridge, England). 54(4)
A new decarbonylation reaction is observed for [(K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ae5dec7710d811c5fefb3cdac6819a5
https://pubmed.ncbi.nlm.nih.gov/29226932
https://pubmed.ncbi.nlm.nih.gov/29226932
Autor:
Andrii Piatkivskyi, Victor Ryzhov, John T. Lawler, Sandra Osburn, Michael Lesslie, Travis R. Helgren, Richard A. J. O'Hair
Publikováno v:
International Journal of Mass Spectrometry. 390:124-131
The effects of hydrogen bonding and spin density at the oxygen atom on the gas-phase reactivity of phenoxyl radicals were investigated experimentally and theoretically in model systems and the dipeptide LysTyr. Gas-phase ion-molecule reactions were c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3122854219482bac684a9d017b2e9c65
https://doi.org/10.1016/j.ijms.2015.06.008
https://doi.org/10.1016/j.ijms.2015.06.008
Publikováno v:
European Journal of Mass Spectrometry. 21:589-597
Radical migration, both intramolecular and intermolecular, from the tyrosine phenoxyl radical Tyr(O•) to the cysteine radical Cys(S•) in model peptide systems was observed in the gas phase. Ion–molecule reactions (IMRs) between the radical cati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d990952d4d55c40338523e690be37da4
https://doi.org/10.1255/ejms.1341
https://doi.org/10.1255/ejms.1341