Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Michael Lerch"'
Autor:
James Cayley, Jason Paino, Susanna Guatelli, Anatoly Rosenfeld, Michael Lerch, Yaw-Ren E. Tan
Publikováno v:
Frontiers in Physics, Vol 12 (2024)
The Pulsed Energetic Electrons for Research (PEER) beamline at the ANSTO Australian Synchrotron comprises a 100 MeV linac injector that is currently being developed for ultra-high dose-rate, very high-energy electron radiotherapy research. Previously
Externí odkaz:
https://doaj.org/article/ec267d32cf5642669b90209c0fa1d209
Autor:
James Cayley, Yaw-Ren E. Tan, Marco Petasecca, Dean Cutajar, Thomas Breslin, Anatoly Rosenfeld, Michael Lerch
Publikováno v:
Frontiers in Physics, Vol 12 (2024)
FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-ener
Externí odkaz:
https://doaj.org/article/5b242ab38cbc453c86cefb97b91cce24
Publikováno v:
Journal of Nanotheranostics, Vol 4, Iss 4, Pp 480-495 (2023)
Targeted brain cancer treatments are sorely needed to improve long-term prognosis, particularly for gliosarcoma and glioblastoma patients. Gold nanoparticles (GNPs) have unique properties including high atomic number, biocompatibility, and small size
Externí odkaz:
https://doaj.org/article/a9c8dcc74ccf447ca9777bdcbed844db
Autor:
Elette Engels, Jason R. Paino, Sarah E. Vogel, Michael Valceski, Abass Khochaiche, Nan Li, Jeremy A. Davis, Alice O’Keefe, Andrew Dipuglia, Matthew Cameron, Micah Barnes, Andrew W. Stevenson, Anatoly Rosenfeld, Michael Lerch, Stéphanie Corde, Moeava Tehei
Publikováno v:
Radiation, Vol 3, Iss 4, Pp 183-202 (2023)
Synchrotron Microbeam Radiation Therapy (MRT) is an innovative technique that spatially segments the synchrotron radiation field for cancer treatment. A microbeam peak dose is often hundreds of times the dose in the valley (the sub-millimeter region
Externí odkaz:
https://doaj.org/article/3ae3e8c988f24431b48b35986efbdfe2
Autor:
Jason Paino, Matthew Cameron, Matthew Large, Micah Barnes, Elette Engels, Sarah Vogel, Moeava Tehei, Stéphanie Corde, Susanna Guatelli, Anatoly Rosenfeld, Michael Lerch
Publikováno v:
Radiation, Vol 3, Iss 2, Pp 123-137 (2023)
This work describes the creation and experimental validation of DoseMRT, a new software package, and its associated workflow for dose calculations in synchrotron-generated broad beam and microbeam radiation treatment fields. The DoseMRT software pack
Externí odkaz:
https://doaj.org/article/34e5c667a9164844a18978ae3eb3d02f
Autor:
Sarah Vogel, Alice O’Keefe, Léa Seban, Michael Valceski, Elette Engels, Abass Khochaiche, Carolyn Hollis, Michael Lerch, Stéphanie Corde, Christophe Massard, Komla Oscar Awitor, Moeava Tehei
Publikováno v:
Journal of Nanotheranostics, Vol 4, Iss 1, Pp 37-54 (2023)
Gold nanoparticles are a promising candidate for developing new strategies of therapy against cancer. Due to their high atomic number and relative biocompatibility, they are commonly investigated as radiosensitizers to locally increase the dose of ra
Externí odkaz:
https://doaj.org/article/18e1370aaac14eafbd06fad5f1e75bb6
Autor:
Elisabeth Schültke, Michael Lerch, Timo Kirschstein, Falko Lange, Katrin Porath, Stefan Fiedler, Jeremy Davis, Jason Paino, Elette Engels, Micah Barnes, Mitzi Klein, Christopher Hall, Daniel Häusermann, Guido Hildebrandt
Publikováno v:
Journal of Synchrotron Radiation, Vol 29, Iss 4, Pp 1027-1032 (2022)
Microbeam radiotherapy could help to cure malignant tumours which are currently still considered therapy-resistant. With an irradiation target in the thoracic cavity, the heart would be one of the most important organs at risk. To assess the acute ad
Externí odkaz:
https://doaj.org/article/7c4f0d17d2424fabbc38e89c641ee115
Autor:
Jeremy Davis, Andrew Dipuglia, Matthew Cameron, Jason Paino, Ashley Cullen, Susanna Guatelli, Marco Petasecca, Anatoly Rosenfeld, Michael Lerch
Publikováno v:
Journal of Synchrotron Radiation, Vol 29, Iss 1, Pp 125-137 (2022)
Successful transition of synchrotron-based microbeam radiation therapy (MRT) from pre-clinical animal studies to human trials is dependent upon ensuring that there are sufficient and adequate measures in place for quality assurance purposes. Transmis
Externí odkaz:
https://doaj.org/article/441a7a1250464ab392af847c502d5c97
Autor:
Thomas Breslin, Jason Paino, Marie Wegner, Elette Engels, Stefan Fiedler, Helen Forrester, Hannes Rennau, John Bustillo, Matthew Cameron, Daniel Häusermann, Christopher Hall, Dieter Krause, Guido Hildebrandt, Michael Lerch, Elisabeth Schültke
Publikováno v:
Biomimetics, Vol 8, Iss 2, p 230 (2023)
The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of t
Externí odkaz:
https://doaj.org/article/5010b267b3f845509d3b0414cf2f17ab
Autor:
Felix Jaekel, Jason Paino, Elette Engels, Mitzi Klein, Micah Barnes, Daniel Häusermann, Christopher Hall, Gang Zheng, Hongxin Wang, Guido Hildebrandt, Michael Lerch, Elisabeth Schültke
Publikováno v:
Cancers, Vol 15, Iss 9, p 2470 (2023)
Microbeam radiotherapy (MRT), a high dose rate radiotherapy technique using spatial dose fractionation at the micrometre range, has shown a high therapeutic efficacy in vivo in different tumour entities, including lung cancer. We have conducted a tox
Externí odkaz:
https://doaj.org/article/518b6127a458431e948c1837b46babcd