Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Michael Lenz"'
Autor:
Shauna D O'Donovan, Rachel Cavill, Florian Wimmenauer, Alexander Lukas, Tobias Stumm, Evgueni Smirnov, Michael Lenz, Gokhan Ertaylan, Danyel G J Jennen, Natal A W van Riel, Kurt Driessens, Ralf L M Peeters, Theo M C M de Kok
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0292030 (2023)
The liver is the primary site for the metabolism and detoxification of many compounds, including pharmaceuticals. Consequently, it is also the primary location for many adverse reactions. As the liver is not readily accessible for sampling in humans;
Externí odkaz:
https://doaj.org/article/6585bbc2c6084525bdf1b8f9ae8698b8
Autor:
Zandra C. Félix Garza, Michael Lenz, Joerg Liebmann, Gökhan Ertaylan, Matthias Born, Ilja C. W. Arts, Peter A. J. Hilbers, Natal A. W. van Riel
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Background Psoriasis and atopic dermatitis are two inflammatory skin diseases with a high prevalence and a significant burden on the patients. Underlying molecular mechanisms include chronic inflammation and abnormal proliferation. However,
Externí odkaz:
https://doaj.org/article/8eda2a98a4ae48ff99f8df736bc516fb
Autor:
Marianthi Kalafati, Michael Lenz, Gökhan Ertaylan, Ilja C. W. Arts, Chris T. Evelo, Marleen M. J. van Greevenbroek, Ellen E. Blaak, Michiel Adriaens, Martina Kutmon
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Background: Macrophages play an important role in regulating adipose tissue function, while their frequencies in adipose tissue vary between individuals. Adipose tissue infiltration by high frequencies of macrophages has been linked to changes in adi
Externí odkaz:
https://doaj.org/article/0a5c1ae7445d48f4a749d06bc0403c53
Autor:
Shauna D O'Donovan, Kurt Driessens, Daniel Lopatta, Florian Wimmenauer, Alexander Lukas, Jelmer Neeven, Tobias Stumm, Evgueni Smirnov, Michael Lenz, Gokhan Ertaylan, Danyel G J Jennen, Natal A W van Riel, Rachel Cavill, Ralf L M Peeters, Theo M C M de Kok
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236392 (2020)
In clinical trials, animal and cell line models are often used to evaluate the potential toxic effects of a novel compound or candidate drug before progressing to human trials. However, relating the results of animal and in vitro model exposures to r
Externí odkaz:
https://doaj.org/article/a72b730386344772802bb761c9e4009c
Autor:
Michael Lenz, Andreas Schulz, Thomas Koeck, Steffen Rapp, Markus Nagler, Madeleine Sauer, Lisa Eggebrecht, Vincent Ten Cate, Marina Panova-Noeva, Jürgen H Prochaska, Karl J Lackner, Thomas Münzel, Kirsten Leineweber, Philipp S Wild, Miguel A Andrade-Navarro
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243487 (2020)
Targeted proteomics utilizing antibody-based proximity extension assays provides sensitive and highly specific quantifications of plasma protein levels. Multivariate analysis of this data is hampered by frequent missing values (random or left censore
Externí odkaz:
https://doaj.org/article/5d98cac7517f43f2b9a0d0058d50a444
Autor:
Shauna D O'Donovan, Michael Lenz, Roel G Vink, Nadia J T Roumans, Theo M C M de Kok, Edwin C M Mariman, Ralf L M Peeters, Natal A W van Riel, Marleen A van Baak, Ilja C W Arts
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 10, p e1007400 (2019)
Given the association of disturbances in non-esterified fatty acid (NEFA) metabolism with the development of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease, computational models of glucose-insulin dynamics have been extended to account for the
Externí odkaz:
https://doaj.org/article/410efcecc5b248518df708c5720dcd97
Autor:
Chaitra Sarathy, Martina Kutmon, Michael Lenz, Michiel E. Adriaens, Chris T. Evelo, Ilja C.W. Arts
Publikováno v:
Metabolites, Vol 10, Iss 2, p 66 (2020)
Elementary Flux Modes (EFMs) are a tool for constraint-based modeling and metabolic network analysis. However, systematic and automated visualization of EFMs, capable of integrating various data types is still a challenge. In this study, we developed
Externí odkaz:
https://doaj.org/article/03c0748845294c2abde2b2dae6e763e8
Autor:
Joana Frobel, Hatim Hemeda, Michael Lenz, Giulio Abagnale, Sylvia Joussen, Bernd Denecke, Tomo Šarić, Martin Zenke, Wolfgang Wagner
Publikováno v:
Stem Cell Reports, Vol 3, Iss 3, Pp 414-422 (2014)
Standardization of mesenchymal stromal cells (MSCs) remains a major obstacle in regenerative medicine. Starting material and culture expansion affect cell preparations and render comparison between studies difficult. In contrast, induced pluripotent
Externí odkaz:
https://doaj.org/article/18a292da6c934ca0bc315026183a2675
Publikováno v:
ZooKeys, Vol 148, Iss 0, Pp 185-196 (2011)
The literature on pairing and mating behavior in termites indicates that a number of distal antennal segments in dealates of both sexes are often removed during colony foundation, with terms such as amputation, mutilation and cannibalism typically em
Externí odkaz:
https://doaj.org/article/fb9ba795ffc0402e9ca0947064d89baf
Autor:
Bernhard M Schuldt, Anke Guhr, Michael Lenz, Sabine Kobold, Ben D MacArthur, Andreas Schuppert, Peter Löser, Franz-Josef Müller
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52068 (2013)
It is widely accepted that the (now reversed) Bush administration's decision to restrict federal funding for human embryonic stem cell (hESC) research to a few "eligible" hESC lines is responsible for the sustained preferential use of a small subset
Externí odkaz:
https://doaj.org/article/a83bdf8b279d4f4dbdae3e1ec0822651