Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Michael Lehrke"'
Autor:
Eva Harlacher, Corinna Schulte, Sonja Vondenhoff, Philippe Schmitt-Kopplin, Philippe Diederich, Christian Hemmers, Julia Moellmann, Julia Wollenhaupt, Rogier Veltrop, Erik Biessen, Michael Lehrke, Björn Peters, Georg Schlieper, Christoph Kuppe, Jürgen Floege, Vera Jankowski, Nikolaus Marx, Joachim Jankowski, Heidi Noels
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Chronic kidney disease (CKD) significantly increases cardiovascular risk and mortality, and the accumulation of uremic toxins in the circulation upon kidney failure contributes to this increased risk. We thus performed a screening for potential novel
Externí odkaz:
https://doaj.org/article/416f4ec891e74c72ab997525426b6b81
Autor:
Kirsten Thiele, Matthias Rau, Niels‐Ulrik Korbinian Hartmann, Marcus Möller, Julia Möllmann, Joachim Jankowski, András P. Keszei, Michael Böhm, Jürgen Floege, Nikolaus Marx, Michael Lehrke
Publikováno v:
ESC Heart Failure, Vol 9, Iss 4, Pp 2233-2238 (2022)
Abstract Aims In this prospective, placebo‐controlled, double‐blind, exploratory study, we examined early and more delayed effects of empagliflozin treatment on haemodynamic parameters (primary endpoint: cardiac output) and kidney function includ
Externí odkaz:
https://doaj.org/article/9f17b380cf264a34a7626044cd0ebb45
Autor:
Fabian Peisker, Maurice Halder, James Nagai, Susanne Ziegler, Nadine Kaesler, Konrad Hoeft, Ronghui Li, Eric M. J. Bindels, Christoph Kuppe, Julia Moellmann, Michael Lehrke, Christian Stoppe, Michael T. Schaub, Rebekka K. Schneider, Ivan Costa, Rafael Kramann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The cardiac vascular niche is of major importance in homeostasis and disease, but knowledge of its complexity in response to injury remains limited. Here we combine lineage tracing with single cell RNA sequencing to show alterations in fibroblasts, e
Externí odkaz:
https://doaj.org/article/19f66c2c61bd4908bcd8a5e61c027ad1
Autor:
Oliver Schnell, Tadej Battelino, Richard Bergenstal, Matthias Blüher, Michael Böhm, Frank Brosius, Richard D. Carr, Antonio Ceriello, Thomas Forst, Francesco Giorgino, Bruno Guerci, Hiddo J. L. Heerspink, Baruch Itzhak, Linong Ji, Mikhail Kosiborod, Nebojša Lalić, Michael Lehrke, Nikolaus Marx, Michael Nauck, Helena W. Rodbard, Giuseppe M. C. Rosano, Peter Rossing, Lars Rydén, Francesca Santilli, Petra-Maria Schumm-Draeger, Per Olav Vandvik, Tina Vilsbøll, Christoph Wanner, Carol Wysham, Eberhard Standl
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract The 7th Cardiovascular Outcome Trial (CVOT) Summit on Cardiovascular, Renal, and Glycemic Outcomes, was held virtually on November 18–19, 2021. Pursuing the tradition of the previous summits, this reference congress served as a platform fo
Externí odkaz:
https://doaj.org/article/00e116eff4ae44ebb18f8fbed0bc075e
Autor:
Andreas Puetz, Anna Artati, Jerzy Adamski, Katharina Schuett, Francesco Romeo, Robert Stoehr, Nikolaus Marx, Massimo Federici, Michael Lehrke, Ben A. Kappel
Publikováno v:
ESC Heart Failure, Vol 9, Iss 1, Pp 564-573 (2022)
Abstract Aims Chronic heart failure with reduced ejection fraction remains a major health issue. To date, no reliable biomarker is available to predict reduced left ventricular ejection fraction (LV‐EF). We aimed to identify novel circulating bioma
Externí odkaz:
https://doaj.org/article/e820c8a5d3dd4a9e950cd8c1b7bf4a0a
Autor:
Florian Kahles, Matthias Rau, Martin Reugels, Ann C. Foldenauer, Robert W. Mertens, Maria C. Arrivas, Jörg Schröder, Paul Idel, Julia Moellmann, Emiel P. C. van der Vorst, Nikolaus Marx, Michael Lehrke
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-7 (2022)
Abstract Background The gut incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by enteroendocrine cells following food intake leading to insulin secretion and glucose lowering. Beyond its
Externí odkaz:
https://doaj.org/article/56d8f207525243cfbb0ca92035964fee
Autor:
Emiel P. C. van der Vorst, Sanne L. Maas, Kosta Theodorou, Linsey J. F. Peters, Han Jin, Timo Rademakers, Marion J. Gijbels, Mat Rousch, Yvonne Jansen, Christian Weber, Michael Lehrke, Corinna Lebherz, Daniela Yildiz, Andreas Ludwig, Jacob F. Bentzon, Erik A. L. Biessen, Marjo M. P. C. Donners
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionThe transmembrane protease A Disintegrin And Metalloproteinase 10 (ADAM10) displays a “pattern regulatory function,” by cleaving a range of membrane-bound proteins. In endothelium, it regulates barrier function, leukocyte recruitment
Externí odkaz:
https://doaj.org/article/f70375b98dbc4f308c54dc71482a5393
Autor:
Julia Wollenhaupt, Janina Frisch, Eva Harlacher, Dickson W.L. Wong, Han Jin, Corinna Schulte, Sonja Vondenhoff, Julia Moellmann, Barbara Mara Klinkhammer, Li Zhang, Adelina Baleanu-Curaj, Elisa A. Liehn, Thimoteus Speer, Andrey Kazakov, Christian Werner, Emiel P.C. van der Vorst, Simina-Ramona Selejan, Mathias Hohl, Michael Böhm, Rafael Kramann, Erik A.L. Biessen, Michael Lehrke, Nikolaus Marx, Joachim Jankowski, Christoph Maack, Peter Boor, Leticia Prates Roma, Heidi Noels
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102459- (2022)
Aims: Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular events and exhibit myocardial changes including left ventricular (LV) hypertrophy and fibrosis, overall referred to as ‘uremic cardiomyopathy’. Although dif
Externí odkaz:
https://doaj.org/article/da483e5c15e143c481fbb9e3d6886c99
Autor:
Naresh Ganesh, Emiel P. C. van der Vorst, Jens Spiesshöfer, Shun He, Mathias Burgmaier, Hannes Findeisen, Michael Lehrke, Filip K. Swirski, Nikolaus Marx, Florian Kahles
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Despite scientific and clinical advances during the last 50 years cardiovascular disease continues to be the main cause of death worldwide. Especially patients with diabetes display a massive increased cardiovascular risk compared to patients without
Externí odkaz:
https://doaj.org/article/2eb45829082e4aa7bcdfadc6b7c84be5
Autor:
Kinan Kneizeh, Andrea Milzi, Felix Vogt, Klaus Witte, Nikolaus Marx, Michael Lehrke, Mohammad Almalla, Jörg Schröder
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 13, p 4243 (2023)
Objectives: We aimed to evaluate the efficacy and safety of low-dose protamine in reducing access site-related complications during Transcatheter Aortic Valve Implantation (TAVI) as compared to full-dose protamine. Background: Access site-related com
Externí odkaz:
https://doaj.org/article/41f58bab3e15455b8f0be7bc98ad1a9b