Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael Lape"'
Autor:
Bahram Namjou, Michael Lape, Edyta Malolepsza, Stanley B. DeVore, Matthew T. Weirauch, Ozan Dikilitas, Gail P. Jarvik, Krzysztof Kiryluk, Iftikhar J. Kullo, Cong Liu, Yuan Luo, Benjamin A. Satterfield, Jordan W. Smoller, Theresa L. Walunas, John Connolly, Patrick Sleiman, Tesfaye B. Mersha, Frank D. Mentch, Hakon Hakonarson, Cynthia A. Prows, Jocelyn M. Biagini, Gurjit K. Khurana Hershey, Lisa J. Martin, Leah Kottyan
Publikováno v:
Journal of Allergy and Clinical Immunology. 150:1086-1096
Asthma is the most common chronic condition in children and the third leading cause of hospitalization in pediatrics. The genome-wide association study catalog reports 140 studies with genome-wide significance. A polygenic risk score (PRS) with predi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97618fd6bf814b05b895cae9f7c02cf
https://doi.org/10.1016/j.jaci.2022.03.035
https://doi.org/10.1016/j.jaci.2022.03.035
Autor:
Shadi Chamseddine, Betul Gok Yavuz, Yehia I. Mohamed, Sunyoung S. Lee, James C. Yao, Zishuo Ian Hu, Michael LaPelusa, Lianchun Xiao, Ryan Sun, Jeffrey S. Morris, Rikita I. Hatia, Manal Hassan, Dan G. Duda, Maria Diab, Amr Mohamed, Ahmed Nassar, Hesham M. Amin, Ahmed Omar Kaseb
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 4, Pp 255-262 (2024)
Introduction: Galectin-3 plays critical roles in the adhesion, proliferation, and differentiation of tumor cells. Recent data have suggested that galectin-3 plays a role in the development of hepatocellular carcinoma (HCC); however, its prognostic va
Externí odkaz:
https://doaj.org/article/c7007e3fd8d74d43a19828dfc72d4de2
Autor:
Ting Wen, Leah C. Kottyan, Amy Eapen, Vincent A. Mukkada, Philip E. Putnam, Avery Maddox, Marc E. Rothenberg, Pablo Abonia, Michael P. Trimarchi, Matthew T. Weirauch, Rahul J. D'Mello, Xiaoming Lu, Michael Lape, Sreeja Parameswaran, Madeline Bonfield, Netali Ben-Baruch Morgenstern, Julie M. Caldwell, Adina Y. Ballaban
Publikováno v:
J Allergy Clin Immunol
BACKGROUND: Eosinophilic esophagitis (EoE) is an emerging, chronic, rare allergic disease associated with marked eosinophil accumulation in the esophagus. Prior genome-wide association studies (GWAS) have provided strong evidence for three genome-wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a7cb82d70217ace672aeb39138932e
https://doi.org/10.1016/j.jaci.2020.10.018
https://doi.org/10.1016/j.jaci.2020.10.018
Autor:
Mariana Saint Just Ribeiro, John B. Harley, Daniel Miller, Albert F. Magnusen, Leah C. Kottyan, Sreeja Parameswaran, Carmy Forney, Michael Lape, Matthew T. Weirauch, Bo Zhao, Iouri Chepelev, Jun Liang, Ted Hong, William E. Miller, Omer Donmez
The interplay between environmental and genetic factors plays a key role in the development of many autoimmune diseases. In particular, the Epstein-Barr virus (EBV) is an established contributor to multiple sclerosis, lupus, and other disorders. Prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df9e542732697b07dce700d67deff23
https://doi.org/10.1101/2020.04.15.043612
https://doi.org/10.1101/2020.04.15.043612
Autor:
Sreeja Parameswaran, Omer Donmez, William E. Miller, Leah C. Kottyan, Albert F. Magnusen, Iouri Chepelev, Carmy Forney, Matthew T. Weirauch, Bo Zhao, John B. Harley, Daniel Miller, Lee Edsall, Mariana Saint Just Ribeiro, Michael Lape, Jun Liang, Ted Hong
Publikováno v:
Genome Res
The interplay between environmental and genetic factors plays a key role in the development of many autoimmune diseases. In particular, the Epstein–Barr virus (EBV) is an established contributor to multiple sclerosis, lupus, and other disorders. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63317ee3fd128b45cb38e5c9f41cf97a
https://pubmed.ncbi.nlm.nih.gov/34799401
https://pubmed.ncbi.nlm.nih.gov/34799401
Autor:
Michael LaPelusa, Haydeé Verduzco-Aguirre, Fernando Diaz, Fernando Aldaco, Enrique Soto-Perez-de-Celis
Publikováno v:
Globalization and Health, Vol 19, Iss 1, Pp 1-8 (2023)
Abstract Background The US-Mexico border is the busiest in the world, with millions of people crossing it daily. However, little is known about cross-border utilization of cancer care, or about the reasons driving it. We designed a cross sectional on
Externí odkaz:
https://doaj.org/article/b77eb0f67d8546e2bd09cb00b5235fa1
Autor:
David T. Stanton, Jodie Zultowsky, Michael Lape, Joel R. Deye, Christopher Elam, Stefan Paula
Publikováno v:
European Journal of Medicinal Chemistry. 46:1512-1523
Two screening protocols based on recursive partitioning and computational ligand docking methodologies, respectively, were employed for virtual screens of a compound library with 345,000 entries for novel inhibitors of the enzyme sarco/endoplasmic re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f218e1cfce6892f8f81e9000073e033c
https://doi.org/10.1016/j.ejmech.2011.01.069
https://doi.org/10.1016/j.ejmech.2011.01.069
Publikováno v:
Biophysical Chemistry. 150:88-97
Inhibitors of the transmembrane protein sarco/endoplasmic reticulum calcium ATPase (SERCA) are invaluable tools for the study of the enzyme’s physiological functions and they have been recognized as a promising new class of anticancer agents. For t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81f23a068428e5c4951a8977a2427b9
https://doi.org/10.1016/j.bpc.2010.01.011
https://doi.org/10.1016/j.bpc.2010.01.011
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:1353-1360
A public compound library with 260,000 compounds was screened virtually by computational docking for novel inhibitors of the transmembrane enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA). Docking was performed with the program GOLD in conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3309ddedb04b00cfeb6fe677e447617
https://doi.org/10.1016/j.bmc.2008.12.010
https://doi.org/10.1016/j.bmc.2008.12.010
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 70:639-649
The ion transport activity of the sarco/endoplasmic reticulum calcium ATPase (SERCA) is specifically and potently inhibited by the small molecule 2,5-di-tert-butylhydroquinone (BHQ). In this study, we investigated the relative importance of the natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61370d4d24258a5e115a51b2bec5882
https://doi.org/10.1002/prot.21542
https://doi.org/10.1002/prot.21542