Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Michael Lanzer"'
Autor:
Micha Rosenkranz, Kristin Fürle, Julia Hibbert, Anne Ulmer, Arin Ali, Thomas Giese, Antje Blank, Walter E. Haefeli, Ernst Böhnlein, Michael Lanzer, Richard Thomson-Luque
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver stages and the disease-causing blood stages of the human malaria parasite Plasmodium falciparum. While substantial progress has been made towards l
Externí odkaz:
https://doaj.org/article/8a2370c07fb045ea9013c090061948cc
Autor:
Fiona Berger, Guillermo M. Gomez, Cecilia P. Sanchez, Britta Posch, Gabrielle Planelles, Farzin Sohraby, Ariane Nunes-Alves, Michael Lanzer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The chloroquine resistance transporter, PfCRT, of the human malaria parasite Plasmodium falciparum is sensitive to acidic pH. Consequently, PfCRT operates at 60% of its maximal drug transport activity at the pH of 5.2 of the digestive vacuol
Externí odkaz:
https://doaj.org/article/4481fd0850c543e2a8b0bb81ca74a0e9
Autor:
Veronika Rathay, Kristin Fürle, Viktoria Kiehl, Anne Ulmer, Michael Lanzer, Richard Thomson-Luque
Publikováno v:
Vaccines, Vol 12, Iss 2, p 208 (2024)
Vaccines are highly effective tools against infectious diseases and are also considered necessary in the fight against malaria. Vaccine-induced immunity is frequently mediated by antibodies. We have recently conducted a first-in-human clinical trial
Externí odkaz:
https://doaj.org/article/08896f3e0c864bdc9c5d9b8211c68d81
Autor:
Guillermo M Gomez, Giulia D'Arrigo, Cecilia P Sanchez, Fiona Berger, Rebecca C Wade, Michael Lanzer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011436 (2023)
The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug histories driving its evolution and, hence, the drug transport specificitie
Externí odkaz:
https://doaj.org/article/4dfce052391d4bef93bf212ea18e6e8b
Autor:
Chi Ho Wai, Jessica Jin, Marek Cyrklaff, Christel Genoud, Charlotta Funaya, Julia Sattler, Aleksandra Maceski, Stephanie Meier, Sabine Heiland, Michael Lanzer, Friedrich Frischknecht, Jens Kuhle, Martin Bendszus, Angelika Hoffmann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Neurofilament light chain (NfL), released during central nervous injury, has evolved as a powerful serum marker of disease severity in many neurological disorders, including infectious diseases. So far NfL has not been assessed in cerebral m
Externí odkaz:
https://doaj.org/article/9bc59db04d294d8c88bf7bb472b2285c
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102536- (2022)
The redox state of the host-parasite unit has been hypothesized to play a central role for the fitness of the intraerythrocytic blood stages of the human malaria parasite Plasmodium falciparum. In particular, hemoglobinopathies have been suggested to
Externí odkaz:
https://doaj.org/article/26d64065d5064f7e9bf306ade1537762
Autor:
Cecilia P. Sanchez, Erin D. T. Manson, Sonia Moliner Cubel, Luis Mandel, Stefan K. Weidt, Michael P. Barrett, Michael Lanzer
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic development of the human malaria parasite Plasmodium falciparum. PfCRT resides at the digestive vacuole of the parasite, where hemoglobin taken up
Externí odkaz:
https://doaj.org/article/d2073372fc434f7889e68c2ee165d4ee
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1009509 (2022)
Red blood cells can withstand the harsh mechanical conditions in the vasculature only because the bending rigidity of their plasma membrane is complemented by the shear elasticity of the underlying spectrin-actin network. During an infection by the m
Externí odkaz:
https://doaj.org/article/9996aa98a6bb48bb8f54bde4b91b2f5c
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-10 (2018)
Abstract Background The increased resistance of the human malaria parasite Plasmodium falciparum to currently employed drugs creates an urgent call for novel anti-malarial drugs. Particularly, efforts should be devoted to developing fast-acting anti-
Externí odkaz:
https://doaj.org/article/c48dd7650b764c84aeefe40a13aad424
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Artemisinins are the current mainstay of malaria chemotherapy. Their exact mode of action is an ongoing matter of debate, and several factors have recently been reported to affect an early stage of artemisinin resistance of the most importan
Externí odkaz:
https://doaj.org/article/80aec3c117b048aab371a5c43075b7a3