Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michael Lamkin"'
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background A major challenge in evaluating quantitative ChIP-seq analyses, such as peak calling and differential binding, is a lack of reliable ground truth data. Accurate simulation of ChIP-seq data can mitigate this challenge, but existing
Externí odkaz:
https://doaj.org/article/e543aa0c7cba4cc1a494ce2d62737998
Autor:
Arya R Massarat, Michael Lamkin, Ciara Reeve, Amy L Williams, Matteo D’Antonio, Melissa Gymrek
Publikováno v:
Bioinformatics. 39
SummaryLeveraging local ancestry and haplotype information in genome-wide association studies and downstream analyses can improve the utility of genomics for individuals from diverse and recently admixed ancestries. However, most existing simulation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ca122a5abcec587d1090bb91df8dba
https://doi.org/10.1093/bioinformatics/btad104
https://doi.org/10.1093/bioinformatics/btad104
Publikováno v:
Nature machine intelligence, vol 3, iss 2
Nature machine intelligence
Nature machine intelligence
Transcription factors (TFs) bind DNA by recognizing specific sequence motifs, typically of length 6-12bp. A motif can occur many thousands of times in the human genome, but only a subset of those sites are actually bound. Here we present a machine le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de42d5765e2c624e209c3e84c88a7005
https://escholarship.org/uc/item/5v61d9jv
https://escholarship.org/uc/item/5v61d9jv
Autor:
Melissa Gymrek, Bonnie Huang, Michael Lamkin, Ileena Mitra, Richard Yanicky, Nichole Ma, Nima Mousavi, Kirk E. Lohmueller, Sharona Shleizer-Burko
Publikováno v:
Nature, vol 589, iss 7841
Nature
Nature
Autism spectrum disorder (ASD) is an early-onset developmental disorder characterized by deficits in communication and social interaction and restrictive or repetitive behaviours1,2. Family studies demonstrate that ASD has a substantial genetic basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92380092ec6740845a57da179355300
https://escholarship.org/uc/item/51g0f6vg
https://escholarship.org/uc/item/51g0f6vg
Autor:
Bonnie Huang, Kirk E. Lohmueller, Michael Lamkin, Nichole Ma, Nima Mousavi, Ileena Mitra, Melissa Gymrek, Richard Yanicky, Sharona Shleizer-Burko
Autism Spectrum Disorder (ASD) is an early onset developmental disorder characterized by deficits in communication and social interaction and restrictive or repetitive behaviors1,2. Family studies demonstrate that ASD has a significant genetic basis3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c78dc67fa63d96faba98a74c22720bf
https://doi.org/10.1101/2020.03.04.974170
https://doi.org/10.1101/2020.03.04.974170
A major challenge in evaluating quantitative ChIP-seq analyses, such as peak calling and differential binding, is a lack of reliable ground truth data. We present Tulip, a toolkit for rapidly simulating ChIP-seq data using statistical models of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87673893fa9500a4ec13084e09ff158
Autor:
Donald Michael Lamkin
Considerable data demonstrate a high prevalence of depression symptoms in patients with cancer, with some studies showing the prevalence for major depressive disorder (MDD) to be as high as 50%. Because depression researchers have found that a signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f04052c673fd3f6455385047f92b22b7
https://doi.org/10.17077/etd.s2tm95rd
https://doi.org/10.17077/etd.s2tm95rd