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pro vyhledávání: '"Michael Laidlaw"'
Practical Synthesis of 7-Bromo-4-chloro-1H-indazol-3-amine: An Important Intermediate to Lenacapavir
Autor:
Naeem Asad, Michael Lyons, Shirley Muniz Machado Rodrigues, Justina M. Burns, Thomas D. Roper, G. Michael Laidlaw, Saeed Ahmad, B. Frank Gupton, Douglas Klumpp, Limei Jin
Publikováno v:
Molecules, Vol 29, Iss 12, p 2705 (2024)
7-Bromo-4-chloro-1H-indazol-3-amine is a heterocyclic fragment used in the synthesis of Lenacapavir, a potent capsid inhibitor for the treatment of HIV-1 infections. In this manuscript, we describe a new approach to synthesizing 7-bromo-4-chloro-1H-i
Externí odkaz:
https://doaj.org/article/58370c2cdc4b470395e7f1bfe475e816
Publikováno v:
Orthopaedic Journal of Sports Medicine
Objectives: The purpose of this study was to quantitatively evaluate the radiographic outcomes of allograft dowels used as bone grafts in two-stage revision anterior cruciate ligament reconstruction (ACLR). Methods: Prospective review of patients who
Publikováno v:
The American Journal of Bioethics. 19:75-77
Contrary to the suggestion in the article, by Priest (2019) watchful waiting with support for gender-dysphoric children and adolescents up to the age of 16 years is the current standard of care wor...
Publikováno v:
Biology of Reproduction. 63:1706-1712
At fertilization in most animals, cortical granules of the egg or oocyte secrete their contents, whose function it is to modify the extracellular matrix. This modified matrix then participates in the block to polyspermy and protection for early embry
Autor:
Yuin-tsee Jennifer Hsu, Gary M. Wessel, Jacqueline M. Brooks, Victor M. Zaydfudim, Michael Laidlaw
Publikováno v:
Development, Growth and Differentiation. 42:507-517
The regulation of yolk storage in oocytes and subsequent utilization in embryos is critical for embryogenesis. In sea urchins, the major yolk protein is made in the intestines, transported to the ovaries and accumulated in developing oocytes within m
Autor:
Jeffrey Harmer, Robert G. Denning, W. Michael Laidlaw, Jennifer C. Green, Amber L. Thompson, Jonathan Boyd
Publikováno v:
Inorganic chemistry. 52(12)
(1)H NMR spectra of the paramagnetic cyanide-bridged mixed-valence compound [(η(5)-C5H5)Fe(CO)2(μ-CN)Ru(NH3)5](CF3SO3)3 (I) have been obtained in several solvents. When traces of partially deuterated water are present, instead of a single cyclopent
Autor:
Michael Laidlaw, Gary M. Wessel
Publikováno v:
Development. 120:1325-1333
Cortical granules are secretory vesicles formed in the eggs of most animals and are essential for the prevention of polyspermy in these organisms. We have studied the biogenesis of cortical granules in sea urchin oocytes by identifying cDNA clones th
Autor:
Robert G. Denning, W. Michael Laidlaw
Publikováno v:
Chemical Communications. :1590
Paramagnetic (hyperfine) NMR shifts in the (13)C cyanide bridge and (31)P resonances in a set of mixed valence complexes [(eta(5)-C(5)R(5))Ru(PPh(3))L((13)CN)Ru(NH(3))(5)](n+) (R = H; L = PPh(3), CO, NO(+); R = Me; L = PPh(3)) are sensitive to the ex
Publikováno v:
Dalton Transactions: An International Journal of Inorganic Chemistry; Nov2008, Vol. 2008 Issue 44, p6257-6264, 8p
Autor:
W. Michael Laidlaw, Robert G. Denning
Publikováno v:
Chemical Communications; Mar2008, Vol. 2008 Issue 13, p1590-1592, 3p