Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Michael L.-H. Huang"'
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102038- (2021)
Due to the high redox activity of the mitochondrion, this organelle can suffer oxidative stress. To manage energy demands while minimizing redox stress, mitochondrial homeostasis is maintained by the dynamic processes of mitochondrial biogenesis, mit
Externí odkaz:
https://doaj.org/article/f4f7a590afe042cbb00cb3bd867a6c2a
Autor:
Suhelen Egan, Zhixuan Wu, Des R. Richardson, Michael L.-H. Huang, Nor Hawani Salikin, Duraippandi Palanimuthu, Nady Braidy
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Alzheimer's disease (AD) is a multifactorial condition leading to cognitive decline and represents a major global health challenge in ageing populations. The lack of effective AD therapeutics led us to develop multifunctional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4ade11538751492ccd259731828334
https://doi.org/10.1111/bph.14963
https://doi.org/10.1111/bph.14963
Autor:
Sumit Sahni, Shannon Chiang, Danuta S. Kalinowski, Michael L.-H. Huang, Des R. Richardson, Dong-Hun Bae
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
The mitochondrion is an essential organelle important for the generation of ATP for cellular function. This is especially critical for cells with high energy demands, such as neurons for signal transmission and cardiomyocytes for the continuous mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8211a56189b9b18f04992313bb1b05dd
https://doi.org/10.1155/2019/6392763
https://doi.org/10.1155/2019/6392763
Autor:
Danuta S. Kalinowski, Patric J. Jansson, Sumit Sahni, Zaklina Kovacevic, Hiu Chuen Lok, Darius J.R. Lane, Michael L.-H. Huang, Angelica M. Merlot, Des R. Richardson
Publikováno v:
Current Medicinal Chemistry. 26:302-322
Metals are vital cellular elements necessary for multiple indispensable biological processes of living organisms, including energy transduction and cell proliferation. Interestingly, alterations in metal levels and also changes in the expression of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06544ef1d10fbf5c3f182d918e4cfbed
https://doi.org/10.2174/0929867324666170705120809
https://doi.org/10.2174/0929867324666170705120809
Autor:
Sharleen V. Menezes, Bekesho Geleta, Leyla Fouani, Des R. Richardson, Michael L.-H. Huang, Sanaz Maleki, Alexander Richardson, Zaklina Kovacevic
Publikováno v:
Carcinogenesis. 40:805-818
The metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1), plays multifaceted roles in inhibiting oncogenic signaling and can suppress the epithelial mesenchymal transition (EMT), a key step in metastasis. In this investigation, NDRG1 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff6ce13c9fb01850e9985cfb42589c6
https://doi.org/10.1093/carcin/bgy178
https://doi.org/10.1093/carcin/bgy178
Publikováno v:
Free radical biologymedicine. 159
Redox stress is associated with the pathogenesis of a wide variety of disease states. This can be amplified potentially through redox active iron deposits in oxidatively active organelles such as the mitochondrion. There are a number of disease state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb58ef61fb06b5445ffe0646c53fe887
https://pubmed.ncbi.nlm.nih.gov/32739593
https://pubmed.ncbi.nlm.nih.gov/32739593
Autor:
Jasmina Paluncic, Michael L.-H. Huang, Yohan Suryo Rahmanto, Dong-Hun Bae, Darius J.R. Lane, Des R. Richardson, Aritee R. Siafakas, Patric J. Jansson, Robert Sutak
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1866(10)
The iron-containing protein, acireductone dioxygenase 1 (ADI1), is a dioxygenase important for polyamine synthesis and proliferation. Using differential proteomics, the studies herein demonstrated that ADI1 was significantly down-regulated by cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f19b530fa551376a6e6345810ed632
https://pubmed.ncbi.nlm.nih.gov/32480040
https://pubmed.ncbi.nlm.nih.gov/32480040
Autor:
Shannon, Chiang, Danuta S, Kalinowski, Mahendiran, Dharmasivam, Nady, Braidy, Des R, Richardson, Michael L H, Huang
Publikováno v:
Pharmacological research. 155
Friedreich's ataxia (FA) is due to deficiency of the mitochondrial protein, frataxin, which results in multiple pathologies including a deadly, hypertrophic cardiomyopathy. Frataxin loss leads to deleterious accumulations of redox-active, mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05141396316ad758f26b125d44b7bb57
https://pubmed.ncbi.nlm.nih.gov/32032665
https://pubmed.ncbi.nlm.nih.gov/32032665
Autor:
Patric J. Jansson, Shannon Chiang, Danuta S. Kalinowski, Michael L.-H. Huang, Des R. Richardson
Publikováno v:
Neurochemistry International. 117:35-48
Mitochondrial homeostasis is essential for maintaining healthy cellular function and survival. The detrimental involvement of mitochondrial dysfunction in neuro-degenerative diseases has recently been highlighted in human conditions, such as Parkinso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeec702b8fda62db382af9aa6d8c1f69
https://doi.org/10.1016/j.neuint.2017.08.002
https://doi.org/10.1016/j.neuint.2017.08.002
Autor:
Michael L.-H. Huang, Lina Al-Akra, Kyung Chan Park, Patric J. Jansson, Sumit Sahni, Darius J.R. Lane, Des R. Richardson, Dong-Hun Bae
Publikováno v:
Journal of Biological Chemistry. 293:3562-3587
Multidrug resistance (MDR) is a major obstacle in cancer treatment due to the ability of tumor cells to efflux chemotherapeutics via drug transporters (e.g. P-glycoprotein (Pgp; ABCB1)). Although the mechanism of Pgp-mediated drug efflux is known at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0339fecf7815c666cae153ab822db3
https://doi.org/10.1074/jbc.m116.772699
https://doi.org/10.1074/jbc.m116.772699