Výsledky vyhledávání - "Michael L. Washburn"

Akademický článek

Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies

Autor: Martin J. Scott, Amanda Jowett, Martin Orecchia, Peter Ertl, Larissa Ouro-Gnao, Julia Ticehurst, David Gower, John Yates, Katie Poulton, Carol Harris, Michael J. Mullin, Kathrine J. Smith, Alan P. Lewis, Nick Barton, Michael L. Washburn, Ruud de Wildt

Publikováno v: mAbs, Vol 12, Iss 1 (2020)

Complex cellular targets such as G protein-coupled receptors (GPCRs), ion channels, and other multi-transmembrane proteins represent a significant challenge for therapeutic antibody discovery, primarily because of poor stability of the target protein

Externí odkaz: https://doaj.org/article/9568bbb2030349d68273fb8c36b14f92

Zobrazit plný text záznamu

Manufacturing‐dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development

Autor: Neeltje Steeghs, Aaron R. Hansen, Glenn J. Hanna, Elena Garralda, Haeseong Park, James Strauss, Michael Adam, Gossett Campbell, Jennifer Carver, Rachael Easton, Katherine Mays, Peter Skrdla, Herbert Struemper, Michael L. Washburn, Christopher Matheny, Sarina A. Piha‐Paul

Publikováno v: Scientia

Biological activity; Solid tumors Actividad biológica; Tumores sólidos Activitat biològica; Tumors sòlids A phase I trial (NCT03447314; 204686) evaluated the safety and efficacy of GSK1795091, a Toll-like receptor 4 (TLR4) agonist, in combination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52a2c776e6853dfc712d9d3e7b04e11
https://doi.org/10.1111/cts.13387

Zobrazit plný text záznamu

Plný text ve formátu HTML

Abstract 1041: Circulating tumor (ct)DNA molecular response rate (MRR) as a potential surrogate for radiologic objective response rate (ORR): A meta-analysis of immunotherapy studies

Autor: Qu Zhang, Andy Houseman, Sammy Yuan, Joe Harding, Helen Zhou, Bin Feng, Michael L. Washburn

Publikováno v: Cancer Research. 83:1041-1041

Background: Previous studies have shown that ctDNA MR defined by 50% reduction of ctDNA levels after immune checkpoint inhibitor (ICI) treatment is significantly associated with improved survival. However, discordance between MR and radiologic respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6a21c94fce0d95f7c5708685c2ebd44
https://doi.org/10.1158/1538-7445.am2023-1041

Zobrazit plný text záznamu

T Cell– and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer

Autor: Zhang Wang, James R. Brown, Victoria N Yi, Katja Remlinger, Ryan C. Fields, Roopa Srinivasan, Amaya I. Wolf, David J. Figueroa, Scott B. Berger, Michael L Washburn, William G. Hawkins, Julie G. Grossman, Stephanie Van Horn, Richard S. Hotchkiss, Heather Madsen, Andrew H. Walton, S. Peter Goedegebuure

Publikováno v: J Immunol

Sepsis is characterized as life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The purpose of this investigation was to determine the differential effect of sepsis on innate versus adaptive immunity, in huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5570a4f7debe961a2b296ba71a9a2674
https://doi.org/10.4049/jimmunol.1900560

Zobrazit plný text záznamu

Akademický článek

LIGHT induces distinct signals to clear an AAV-expressed persistent antigen in the mouse liver and to induce liver inflammation.

Autor: Michael L Washburn, Grigoriy I Kovalev, Ekaterina Koroleva, Yang-Xin Fu, Lishan Su

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10585 (2010)

Infection with adeno-associated virus (AAV) vector with liver tropism leads to persistent expression of foreign antigens in the mouse liver, with no significant liver inflammation or pathology. This provides a model to investigate antigen persistence

Externí odkaz: https://doaj.org/article/0f65472958284bf3bcd02ac75cf3b2c3

Zobrazit plný text záznamu

Efficacy and Safety of Danirixin (GSK1325756) Co-administered With Standard-of-Care Antiviral (Oseltamivir): A Phase 2b, Global, Randomized Study of Adults Hospitalized With Influenza

Autor: Phillip J. Yates, Sumita Roy-Ghanta, G B Roberts, Michael L Washburn, Andrew J. Peat, Michael F. Parry, Yu Tao, Anuradha Madan, Shuguang Chen, Otis Barnum, Micah T. McClain

Publikováno v: Open Forum Infectious Diseases

Background Excessive neutrophil migration has been correlated with influenza symptom severity. Danirixin (GSK1325756), a selective and reversible antagonist of C-X-C chemokine receptor 2, decreases neutrophil activation and transmigration to areas of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd2ee6bdf4a1dd77252a6e6a1f1dda1
http://europepmc.org/articles/PMC6483311

Zobrazit plný text záznamu

Plný text ve formátu HTML

Safety, Pharmacokinetics, and Pharmacodynamics of the TLR4 Agonist GSK1795091 in Healthy Individuals: Results from a Randomized, Double-blind, Placebo-controlled, Ascending Dose Study

Autor: Michael L. Washburn, Christopher Matheny, Xiaowei Wang, Bruce A. Hug, Olivia Burns, Herbert Struemper

Publikováno v: Clinical Therapeutics. 42:1519-1534.e33

Purpose Interest in Toll-like receptor (TLR) agonists for cancer treatment has been renewed after promising preliminary clinical data in combination with checkpoint inhibitors. This first-in-human study assessed the safety, tolerability, and pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78d68e8f9fe79e6dd85e977dcf9f8f7
https://doi.org/10.1016/j.clinthera.2020.05.022

Zobrazit plný text záznamu

Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Tolerability, and Clinical Effect of Danirixin in Adults With Acute, Uncomplicated Influenza

Autor: Jill Walker, Michael L Washburn, Sumita Roy-Ghanta, Phillip J. Yates, Andrew J. Peat, Edward Kerwin, Gary Soucie, G B Roberts, Anuradha Madan, Shuguang Chen

Publikováno v: Open Forum Infectious Diseases

Background Danirixin (DNX), a selective and reversible CXC chemokine receptor 2 antagonist, inhibits neutrophil transmigration and activation. This study assessed the safety, tolerability, and clinical effect of DNX with and without oseltamivir (OSV)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bf4c2018885962312eb8f9d8d39aee
https://pubmed.ncbi.nlm.nih.gov/31024969

Zobrazit plný text záznamu

Reducing the Risk of Adeno-Associated Virus (AAV) Vector Mobilization with AAV Type 5 Vectors

Autor: R. Jude Samulski, Shelley K. Cockrell, Steven J. Gray, F. Curtis Hewitt, Michael L. Washburn, Chengwen Li

Publikováno v: Journal of Virology. 83:3919-3929

Current adeno-associated virus (AAV) gene therapy vectors package a transgene flanked by the terminal repeats (TRs) of AAV type 2 (AAV2). Although these vectors are replication deficient, wild-type (wt) AAV2 prevalent in the human population could le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79282f05f643398ba8ee160d06981bd8
https://doi.org/10.1128/jvi.02466-08

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání