Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Michael L. Schlador"'
Publikováno v:
Journal of Biological Chemistry. 275:23295-23302
Endocytosis of agonist-activated G protein-coupled receptors (GPCRs) is required for both resensitization and recycling to the cell surface as well as lysosomal degradation. Thus, this process is crucial for regulation of receptor signaling and cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95966c5857c071434cd9973d9eaa1754
https://doi.org/10.1074/jbc.m002380200
https://doi.org/10.1074/jbc.m002380200
Autor:
Michael L. Schlador, Neil M. Nathanson, Susan E. Hamilton, Renée S. Chmelar, Lise A. McKinnon
Publikováno v:
Journal of Physiology-Paris. 92:275-278
The regulation of muscarinic acetylcholine receptor expression and function was investigated in cultured cells and in knockout mice. Muscarinic agonist exposure causes m2 receptor desensitization and sequestration and decreases the exprssion of cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6355a721768afc33d9d03315a899a83
https://doi.org/10.1016/s0928-4257(98)80032-6
https://doi.org/10.1016/s0928-4257(98)80032-6
Autor:
Neil M. Nathanson, Michael L. Schlador
Publikováno v:
The Journal of biological chemistry. 272(30)
The m2 muscarinic acetylcholine receptor (m2 mAChR) belongs to the superfamily of G protein-coupled receptors and is regulated by many processes that attenuate signaling following prolonged stimulation by agonist. We used a heterologous expression sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d93e1237e6eb8f549c89a419ed3ecba
https://pubmed.ncbi.nlm.nih.gov/9228066
https://pubmed.ncbi.nlm.nih.gov/9228066
Autor:
Michael L. Schlador, Sarabeth L. Thomas, Neil M. Nathanson, Lise A. McKinnon, Marc L. Rosoff, Susan E. Hamilton
Publikováno v:
Life sciences. 60(13-14)
We have investigated the molecular and cellular basis for the regulation of expression and function of the muscarinic acetylcholine receptors. Treatment of cultured chick cardiac cells with the agonist carbachol results in decreased levels of mRNA en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbe5ca8b94bc8bed82ca21e933d2e5d
https://pubmed.ncbi.nlm.nih.gov/9121353
https://pubmed.ncbi.nlm.nih.gov/9121353
Publikováno v:
The Journal of biological chemistry. 271(8)
When the m1 and m2 muscarinic acetylcholine receptors are transiently expressed in JEG-3 cells, the m2, but not the m1, receptor undergoes agonist-induced sequestration. Both receptors exhibit internalization when expressed in Y1 cells. These results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f09c52df60a73c358fe79a335fc0b8
https://pubmed.ncbi.nlm.nih.gov/8626765
https://pubmed.ncbi.nlm.nih.gov/8626765
Publikováno v:
Life Sciences. 64:562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a3334894ae8d9d7293b4d4e20f07703
https://doi.org/10.1016/s0024-3205(99)90480-0
https://doi.org/10.1016/s0024-3205(99)90480-0