Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael L. Pritt"'
Autor:
Albert E. Schultze, Enaksha R. Wickremsinhe, Matthew Renninger, April Paulman, Michael L. Pritt
Publikováno v:
Toxicologic Pathology. 44:1013-1020
Sampling blood for toxicokinetic (TK) evaluation in rodents is typically performed using a satellite group of animals to avoid depleting the blood volume and inducing an additional stressor in the main study animals. This practice does not allow for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf5b7e86f5514690208e76911f5738e
https://doi.org/10.1177/0192623316656285
https://doi.org/10.1177/0192623316656285
Autor:
Natalie R Russell, Michael R. Elwell, Michael L. Pritt, Steven D. Sorden, Paul D. Cornwell, John L. Vahle, Manoj Bhaskaran
Publikováno v:
Toxicologic pathology. 46(4)
Inhibitors of Bruton’s tyrosine kinase (BTK) are under development as potential therapies for various autoimmune diseases. In repeat-dose toxicity studies, small-molecule BTK inhibitors (BTKi) have been reported to cause a constellation of histolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39f0ac36ae4cb2c3923c999b51e3701
https://pubmed.ncbi.nlm.nih.gov/29699458
https://pubmed.ncbi.nlm.nih.gov/29699458
Autor:
Holly W. Smith, D. Greg Hall, Bradley W. Main, Michael L. Pritt, H.-Y. Cindy Lee, Wherly P. Hoffman, Bradley L. Ackermann, A. Eric Schultze
Publikováno v:
Toxicologic Pathology. 39:576-588
The authors compared the mortality and cardiac biomarker responses in three outbred stocks of Sprague Dawley rats (CD/IGS, Sasco, Harlan) treated with isoproterenol hydrochloride. Cardiac injury was confirmed by histologic evaluation, and increases i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d3ba43785b83e8859fa6d9da174705
https://doi.org/10.1177/0192623311402219
https://doi.org/10.1177/0192623311402219
Autor:
Michael J. Berna, David E. Watson, Bradley L. Ackermann, Michael L. Pritt, John E. Hale, Zhaoyan Jin, Eugene Y. Zhen
Publikováno v:
PROTEOMICS – Clinical Applications. 1:661-671
Heart fatty acid binding protein (Fabp3) is a cytosolic protein expressed primarily in heart, and to a lesser extent in skeletal muscle, brain, and kidney. During myocardial injury, the Fabp3 level in serum is elevated rapidly, making it an ideal ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4d25e8f2d7b1fb7fae7cfec3a1ed84
https://doi.org/10.1002/prca.200700006
https://doi.org/10.1002/prca.200700006
Autor:
D. Greg Hall, David E. Watson, Kevin K.W. Wang, Darryl W. Ballard, Uwe Müller, Michael L. Pritt, William H. Jordan
Over-activation of calpain and the resulting proteolysis of dozens of proteins has been linked to a variety of degenerative conditions in the brain (Mansouri et al., 2007; Vanderklish & Bahr, 2000), and may be the unifying mechanistic event in stroke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce883dfb3be76d5bf343c49cce4a1ba1
https://europepmc.org/articles/PMC4833023/
https://europepmc.org/articles/PMC4833023/
Autor:
Michael J. Berna, David E. Watson, Hong Liu, Steven K. Engle, Albert E. Schultze, Kelly M. Credille, Michael L. Pritt, Philip F. Solter, Christopher M. Bull, Alan Y. Chiang, Emily C. Rothstein, Stephanie Adams, Michael D. Cockman, Yuefeng Lu
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 114(2)
Chronic treatment with suprapharmacologic doses of peroxisome proliferator-activated receptor (PPAR) agonists has a known potential for causing left ventricular hypertrophy (LVH). The mechanism by which LVH develops is not well understood nor are bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c390d01bf07dfa45aca835490674d6f
https://pubmed.ncbi.nlm.nih.gov/20044590
https://pubmed.ncbi.nlm.nih.gov/20044590
Autor:
Armando R. Irizarry, David E. Watson, Alan Y. Chiang, Paul D. Cornwell, Yumi Yamamoto, A. Eric Schultze, Kathleen M. Heinz-Taheny, Zimmermann John Lyle, Daniel G. Rudmann, David Mendel, William H. Jordan, Myrtle Davis, Steven K. Engle, Michael L. Pritt
Publikováno v:
Toxicologic pathology. 37(5)
Cardiac troponin I is a useful biomarker of myocardial injury, but its use in mice and application to early drug discovery are not well described. The authors investigated the relationship between cTnI concentration in serum and histologic lesions in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca4ff356dfe09e0eaa3315b6c437ba3
https://pubmed.ncbi.nlm.nih.gov/19549929
https://pubmed.ncbi.nlm.nih.gov/19549929
Fabp3 as a biomarker of skeletal muscle toxicity in the rat: comparison with conventional biomarkers
Autor:
Albert E. Schultze, David E. Watson, Nathan P. Yumibe, Kelly M. Credille, David Greg Hall, Michael L. Pritt, Donna D. Brown, Justin Recknor
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 103(2)
Fatty acid binding protein 3 (Fabp3) has been used as a serological biomarker of cardiac injury, but its utility as a preclinical biomarker of injury to skeletal muscle is not well described. Fabp3 concentrations were determined for tissues from Spra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d1e8d9515e7df372438712ea81c8f7
https://pubmed.ncbi.nlm.nih.gov/18308699
https://pubmed.ncbi.nlm.nih.gov/18308699
Autor:
Holly A. Bina, Carma Maples, Nita J. Patel, Naijia Helen Huang, Yu-hua Hui, Lewis Ebbert, Tom Kern, Michael L. Pritt, Alan Chiang
Publikováno v:
Journal of pharmacological and toxicological methods. 56(2)
The evaluation of drug disposition properties of chemical entities in drug discovery research typically involves the conduct of pharmacokinetic studies in rodents that requires blood sampling over several time points, preferably without disrupting th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab24aeea22a5aef82adab6edab8d8d5
https://pubmed.ncbi.nlm.nih.gov/17618130
https://pubmed.ncbi.nlm.nih.gov/17618130
Autor:
Michael L. Pritt, David Greg Hall, Justin Recknor, Kelly M. Credille, Donna D. Brown, Nathan P. Yumibe, Albert Eric Schultze, David E. Watson
Publikováno v:
Toxicological Sciences; Jun2008, Vol. 103 Issue 2, p382-382, 1p