Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Michael L. Nosella"'
Autor:
Alyssa Pastic, Michael L. Nosella, Annahat Kochhar, Zi Hao Liu, Julie D. Forman-Kay, Damien D’Amours
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114419- (2024)
Summary: The compaction of chromatin into mitotic chromosomes is essential for faithful transmission of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated by the condensin complex, though the exact mechanism used to
Externí odkaz:
https://doaj.org/article/dbfc8f88d5674f159a36f7d4dc387b8c
Autor:
Tae Hun Kim, Michael L. Nosella, Nicolas Bolik-Coulon, Robert W. Harkness, Shuya Kate Huang, Lewis E. Kay
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Epigenetic modifications of chromatin play a critical role in regulating the fidelity of the genetic code and in controlling the translation of genetic information into the protein components of the cell. One key posttranslational modification is ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b762aa1c4dc9822749594faa42076058
https://doi.org/10.1073/pnas.2301063120
https://doi.org/10.1073/pnas.2301063120
Autor:
Jeffrey A. Toretsky, Hyun O Lee, Michael L Nosella, Iva Pritišanac, Julie D. Forman-Kay, P. Andrew Chong, Maria Tereshchenko
Publikováno v:
Journal of the American Chemical Society. 143:11520-11534
Many membraneless organelles are thought to be biomolecular condensates formed by phase separation of proteins and other biopolymers. Post-translational modifications (PTMs) can impact protein phase separation behavior, although for many PTMs this as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d0021368f21baf3e65edf2481dfaac
https://doi.org/10.1021/jacs.1c04194
https://doi.org/10.1021/jacs.1c04194
Autor:
Julie D. Forman-Kay, Yuki Toyama, Michael L Nosella, Tae Hun Kim, Brandon J. Payliss, Ian T W Lee, Lewis E. Kay
Publikováno v:
Proc Natl Acad Sci U S A
The role of biomolecular condensates in regulating biological function and the importance of dynamic interactions involving intrinsically disordered protein regions (IDRs) in their assembly are increasingly appreciated. While computational and theore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743750ca01120b5d173e913c2330a71f
https://pubmed.ncbi.nlm.nih.gov/34074792
https://pubmed.ncbi.nlm.nih.gov/34074792
Autor:
Michael L Nosella, Julie D. Forman-Kay
Publikováno v:
Current opinion in cell biology. 69
Regulation of messenger RNA (mRNA) transcription, processing and translation occurs in the context of biomolecular condensates. How the physical properties of condensates connect with their biological regulatory functions is an ongoing area of intere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3a1dfbd88558e15ebeaac00ab0a1ac
https://pubmed.ncbi.nlm.nih.gov/33450720
https://pubmed.ncbi.nlm.nih.gov/33450720
Autor:
Michael L Nosella, M. Pisiren, R. Fernandez de la Fuente, Brian Tsang, Gabriella Viero, Cristian Bodo, Pietro Fratta, Maria Giovanna Garone, Giampietro Schiavo, Alessandro Rosa, Francesca Mattedi, Oscar G. Wilkins, Elizabeth M. C. Fisher, Agnieszka M. Ule, Jack Humphrey, Seth Jarvis, Julie D. Forman-Kay, P.A. Chong, Nicol Birsa, Anny Devoy
SummaryMutations in the RNA binding protein (RBP) FUS cause amyotrophic lateral sclerosis (ALS) and result in its nuclear depletion and cytoplasmic mislocalisation, with cytoplasmic gain of function thought to be crucial in pathogenesis. Here, we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eb4c516e21f08cc3c507384d236bb23
https://doi.org/10.1101/2020.09.14.296038
https://doi.org/10.1101/2020.09.14.296038
