Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael L. Mulhern"'
Autor:
Periyasamy Palsamy, Toshimichi Shinohara, Christian J. Madson, Rajan Elanchezhian, Andrew Troia, Michael L. Mulhern
Publikováno v:
Biomedicine & Aging Pathology. 2:143-150
Retinitis pigmentosa (RP) is associated with the expression of a mutant photoreceptor-specific protein. We hypothesized that missorted mutant rhodopsin induces an evolutionarily conserved compensatory mechanism known as the unfolded protein response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a91131d41a726fb981a825f0918ddac
https://doi.org/10.1016/j.biomag.2012.10.003
https://doi.org/10.1016/j.biomag.2012.10.003
Autor:
Preeti R. Poley, Eyal Margalit, Fang Qui, Michael L. Mulhern, William M Stapleton, David D Ingvoldstad
Publikováno v:
Expert Review of Ophthalmology. 6:195-201
The pathogenesis of choroidal neovascular membrane in neovascular age-related macular degeneration (AMD) is multifactorial and involves angiogenesis, inflammation and other yet to be discovered entities. The role of angiogenesis in this disease proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4e7fabf4395d22d053c687437db918
https://doi.org/10.1586/eop.11.6
https://doi.org/10.1586/eop.11.6
Publikováno v:
Experimental Eye Research. 83:508-516
Cataract is a multifactorial disease, and a large variety of stressors induce cataracts. Many cataractogenic stressors and endoplasmic reticulum (ER) stressors induce the unfolded protein response (UPR) in various cell types. The UPR is known to prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc57e1d002e0b55a7f73d4de9846c1fd
https://doi.org/10.1016/j.exer.2006.01.033
https://doi.org/10.1016/j.exer.2006.01.033
Human lens membranes contain the highest cholesterol concentration of any known biological membranes, but it significantly decreases with age. Oxygenation of cholesterol generates numerous forms of oxysterols (bile acids). We previously showed that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5f5ec7ef3d0961b1857e238432b29a
https://europepmc.org/articles/PMC3156260/
https://europepmc.org/articles/PMC3156260/
Autor:
Thomas Hejkal, David D Ingvoldstad, Jane L. Meza, Eyal Margalit, Michael L. Mulhern, Fang Qiu, Aaron M. Alme
Publikováno v:
BMC Ophthalmology
BMC Ophthalmology, Vol 8, Iss 1, p 23 (2008)
BMC Ophthalmology, Vol 8, Iss 1, p 23 (2008)
Background The Early Treatment for Retinopathy of Prematurity study (ETROP), published in 2003, established new guidelines for treatment of retinopathy of prematurity (ROP) and demonstrated improved outcomes compared to previous guidelines. We examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b5e4911de9c6a038af6c22a69564c0
https://pubmed.ncbi.nlm.nih.gov/19014557
https://pubmed.ncbi.nlm.nih.gov/19014557
Autor:
Michael L, Mulhern, Christian J, Madson, Peter F, Kador, James, Randazzo, Toshimichi, Shinohara
Publikováno v:
Molecular vision. 13
Many cataractogenic stresses also induce endoplasmic reticulum (ER) stress in lens epithelial cells (LECs), which appears to be one of the universal inducers of cell death. In galactosemic rats, activation of ER stress results in the activation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa01b5d8fc0bafb506f9f7f229029082
https://pubmed.ncbi.nlm.nih.gov/17768385
https://pubmed.ncbi.nlm.nih.gov/17768385
Autor:
Todd A. Wyatt, Rebecca E. Slager, Debra J. Romberger, Susanna G. Von Essen, Brent W. Auvermann, Michael L. Mulhern, Anthony A. Floreani, Tracy Mathisen, Jane M. DeVasure
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 293(5)
Individuals exposed to dusts from concentrated animal feeding operations report increased numbers of respiratory tract symptoms, and bronchoalveolar lavage samples from such individuals demonstrate elevated lung inflammatory mediators, including inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667583f1e722b5267154808862139452
https://pubmed.ncbi.nlm.nih.gov/17720876
https://pubmed.ncbi.nlm.nih.gov/17720876
Publikováno v:
Medical hypotheses. 70(2)
A mutation in retinal photoreceptor-specific proteins causes nearly 50% of retinitis pigmentosa (RP) cases; the other 50% is called sporadic RP, the etiology of which is unknown. To alleviate RP development, gene therapies, including insertion of a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83927b3c0d5c3ef13326e96bd2eb1f70
https://pubmed.ncbi.nlm.nih.gov/17590524
https://pubmed.ncbi.nlm.nih.gov/17590524
Autor:
Kengo Ikesugi, Christian J. Madson, Peter F. Kador, Michael L. Mulhern, Toshimichi Shinohara, Ken Ichi Hosoya, Tetsuya Terasaki
Publikováno v:
Current eye research. 31(11)
Diabetic retinopathy is one of the major microvascular complications associated with diabetes mellitus, and the selective degeneration of retinal capillary pericytes is considered to be a hallmark of early retinopathy. Because glucose fluctuations co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5ce50c51413b668ce174677a7b7b0c
https://pubmed.ncbi.nlm.nih.gov/17114120
https://pubmed.ncbi.nlm.nih.gov/17114120
Publikováno v:
Medical hypotheses. 69(3)
Cataract is the leading cause of visual handicap throughout the world, and almost all elderly individuals develop lens opacities. Epidemiological studies have shown that nuclear cataracts in young adults are associated with higher mortality. Many cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96df2f0ae354a847d684c8b96090aee
https://pubmed.ncbi.nlm.nih.gov/17337126
https://pubmed.ncbi.nlm.nih.gov/17337126