Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michael L. Mohler"'
Autor:
Michael L. Mohler, Ramesh Narayanan, Duane D. Miller, Dong Jin Hwang, Yali He, Thirumagal Thiyagarajan, Suriyan Ponnusamy
Publikováno v:
J Med Chem
A series of propanamide derivatives were designed, synthesized, and pharmacologically characterized as selective androgen receptor degraders (SARDs) and pan-antagonists that exert a broad-scope androgen receptor (AR) antagonism. Incorporating differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3694a2be4b545e13a35265286a84a3
https://doi.org/10.1021/acs.jmedchem.1c00439
https://doi.org/10.1021/acs.jmedchem.1c00439
Autor:
Michael L. Mohler, James T. Dalton
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98df38c0b771a842c54c56dd95a6a750
https://doi.org/10.1002/0471266949.bmc055.pub2
https://doi.org/10.1002/0471266949.bmc055.pub2
Autor:
Suriyan Ponnusamy, Duane D. Miller, Dong Jin Hwang, Ramesh Narayanan, Michael L. Mohler, Yali He, Arunima Sikdar
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2124, p 2124 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of the androgen receptor (AR) signaling axis since Huggins et al. discovered that diethylstilbestrol (DES; an estrogen) produced chemical castration and PCa tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8892927c9cb740b5e431f331794aff9
https://www.mdpi.com/1422-0067/22/4/2124
https://www.mdpi.com/1422-0067/22/4/2124
Autor:
Ramesh Narayanan, Muralimohan Yepuru, Christopher C Coss, Zhongzhi Wu, Matthew N Bauler, Christina M Barrett, Michael L Mohler, Yun Wang, Juhyun Kim, Linda M Snyder, Yali He, Nelson Levy, Duane D Miller, James T Dalton
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83380 (2013)
Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation. Increased expression, activating mutations and rearra
Externí odkaz:
https://doaj.org/article/99a4bb75c3cc4be7b28f17e6807eb989
Autor:
Duane D. Miller, Michael L. Mohler, Dong Jin Hwang, Yali He, Thirumagal Thiyagarajan, Ramesh Narayanan, Suriyan Ponnusamy
Publikováno v:
J Med Chem
We report herein the design, synthesis, and pharmacological characterization of a library of novel aryl pyrazol-1-yl-propanamides as selective androgen receptor degraders (SARDs) and pan-antagonists that exert broad-scope AR antagonism. Pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab0d7542920c5aef5171618e5f1309c
https://pubmed.ncbi.nlm.nih.gov/33095584
https://pubmed.ncbi.nlm.nih.gov/33095584
Autor:
Duane D. Miller, Suriyan Ponnusamy, Ramesh Narayanan, Dong Jin Hwang, Thirumagal Thiyagarajan, Michael L. Mohler, Yali He, Iain J. McEwan
Publikováno v:
Journal of medicinal chemistry. 62(2)
In our effort to find small-molecule treatments of advanced prostate cancers (PCs), a novel series of indolyl and indolinyl propanamides (series II and III) were discovered as selective androgen receptor degraders (SARDs). Initial studies of androgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6bb7f55eefdb3f3095b6cd174f296c
https://pubmed.ncbi.nlm.nih.gov/30525603
https://pubmed.ncbi.nlm.nih.gov/30525603
Autor:
Chien-Ming Li, Jianjun Chen, Michael L. Mohler, Wei Li, Zhao Wang, James T. Dalton, Yan Lu, Duane D. Miller
Publikováno v:
Journal of Medicinal Chemistry. 54:4678-4693
In a continued effort to improve upon the previously published 4-substituted methoxybenzoyl-aryl-thiazole (SMART) template, we explored chemodiverse "B" rings and "B" to "C" ring linkage. Further, to overcome the poor aqueous solubility of this serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090f495140803df8d363bade09f60289
https://doi.org/10.1021/jm2003427
https://doi.org/10.1021/jm2003427
Autor:
Ramesh Narayanan, Yali He, Christopher C. Coss, Michael L. Mohler, Kejiang Hu, Zhongzhi Wu, Duane D. Miller, Seoung-Soo Hong, James T. Dalton, Dong Jin Hwang
Publikováno v:
Expert Opinion on Therapeutic Patents. 20:507-534
Nonsteroidal estrogens have been known since the 1930s. However, the relatively recent (1996) discovery of estrogen receptor subtype beta (ERbeta) suggested a possible paradigm shift away from SERM-like selectivity. Selective ERbeta agonism would pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a735164093d62e3cb413e92265c5c03
https://doi.org/10.1517/13543771003657164
https://doi.org/10.1517/13543771003657164
Autor:
Michael L. Mohler, Christopher C. Coss, Miller Duane D, James T. Dalton, Dong Jin Hwang, Casey E. Bohl, Amanda Jones, Yali He, Ramesh Narayanan
Publikováno v:
Journal of Medicinal Chemistry. 52:3597-3617
Interest in the development and therapeutic potential of nonsteroidal tissue-selective androgen receptor modulators (SARMs) has increased dramatically within the past decade. Rapidly expanding knowledge of nuclear hormone receptor structure and funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591b81f5bccbdc01ddf9a317ac6944bf
https://doi.org/10.1021/jm900280m
https://doi.org/10.1021/jm900280m
Publikováno v:
Medicinal Research Reviews. 29:125-195
Diabetes is a disease that affects over 150 million people worldwide for which there are multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, diabetes rates in both developed and developing countries are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4a70ef26eceabb704bc08c25d1e57f
https://doi.org/10.1002/med.20142
https://doi.org/10.1002/med.20142