Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Michael L. McDaniel"'
Autor:
Takashi Izawa, Nidhi Rohatgi, Tomohiro Fukunaga, Qun-Tian Wang, Matthew J. Silva, Michael J. Gardner, Michael L. McDaniel, Nada A. Abumrad, Clay F. Semenkovich, Steven L. Teitelbaum, Wei Zou
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1625-1637 (2015)
ASXL2 is an ETP family protein that interacts with PPARγ. We find that ASXL2−/− mice are insulin resistant, lipodystrophic, and fail to respond to a high-fat diet. Consistent with genetic variation at the ASXL2 locus and human bone mineral densi
Externí odkaz:
https://doaj.org/article/ce0944edd0ab4b6898f393fa3471335c
Autor:
Manu V. Chakravarthy, Yimin Zhu, Li Yin, Trey Coleman, Kirk L. Pappan, Connie A. Marshall, Michael L. McDaniel, Clay F. Semenkovich
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 4, Pp 630-640 (2009)
Obesity promotes insulin resistance and chronic inflammation. Disrupting any of several distinct steps in lipid synthesis decreases adiposity, but it is unclear if this approach coordinately corrects the environment that propagates metabolic disease.
Externí odkaz:
https://doaj.org/article/136c070a5f4a455f908c56e57236950b
Autor:
Haytham Aly, Nidhi Rohatgi, Connie A Marshall, Tiffani C Grossenheider, Hiroyuki Miyoshi, Thaddeus S Stappenbeck, Scot J Matkovich, Michael L McDaniel
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66131 (2013)
Our previous studies demonstrated that Wnt/GSK-3/β-catenin and mTOR signaling are necessary to stimulate proliferative processes in adult human β-cells. Direct inhibition of GSK-3, that engages Wnt signaling downstream of the Wnt receptor, increase
Externí odkaz:
https://doaj.org/article/5fd82f224eb0466dbcad8713a11f8da7
Autor:
Nidhi Rohatgi, Haytham Aly, Connie A Marshall, William G McDonald, Rolf F Kletzien, Jerry R Colca, Michael L McDaniel
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62012 (2013)
Major bottlenecks in the expansion of human β-cell mass are limited proliferation, loss of β-cell phenotype, and increased apoptosis. In our previous studies, activation of Wnt and mTOR signaling significantly enhanced human β-cell proliferation.
Externí odkaz:
https://doaj.org/article/bc975e54597c422dabc6f327d40e0ddf
Autor:
Michael L. McDaniel
Publikováno v:
23rd AIAA Lighter-Than-Air Systems Technology Conference.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d240569f25d462d291765450fae164a
https://doi.org/10.2514/6.2017-4135
https://doi.org/10.2514/6.2017-4135
Autor:
Michael L. McDaniel
Publikováno v:
AIAA Flight Testing Conference.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d88066b195a08e5f82fb43c2d89f78e
https://doi.org/10.2514/6.2017-3138
https://doi.org/10.2514/6.2017-3138
Autor:
Fumihiko Urano, Rebecca J. Godar, Maria S. Remedi, Paul Saftig, John T. Murphy, Krzysztof L. Hyrc, Nidhi Rohatgi, Abhinav Diwan, Xiucui Ma, Babak Razani, Haiyan Liu, Jana Mahadevan, Ali Javaheri, Michael L. McDaniel, Connie A. Marshall
Obesity-induced diabetes is characterized by hyperglycemia, insulin resistance, and progressive beta cell failure. In islets of mice with obesity-induced diabetes, we observe increased beta cell death and impaired autophagic flux. We hypothesized tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a951201952045e9b2d679846ec0b3c
Autor:
Theresa Weber, Stephanie Vernier, Timothy McPherson, Phuong Nguyen, Andrew S. Greenberg, Joseph Schober, Connie A. Marshall, Michael L. McDaniel, Mark Luer, Nidhi Rohatgi, Angela Chiu, Guim Kwon, Paul E. Wanda
Publikováno v:
Islets
The aim of this study was to assess multifactorial β-cell responses to metabolic perturbations in primary rat and human islets. Treatment of dispersed rat islet cells with elevated glucose and free fatty acids (FFAs, oleate:palmitate = 1:1 v/v) resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5615d8415849f365cdbc81e4a3a461
http://europepmc.org/articles/PMC3605166
http://europepmc.org/articles/PMC3605166
Autor:
Michael L. McDaniel, Trey Coleman, Li Yin, Manu V. Chakravarthy, Connie A. Marshall, Kirk L. Pappan, Clay F. Semenkovich, Yimin Zhu
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 4, Pp 630-640 (2009)
Journal of Lipid Research
Journal of Lipid Research
Obesity promotes insulin resistance and chronic inflammation. Disrupting any of several distinct steps in lipid synthesis decreases adiposity, but it is unclear if this approach coordinately corrects the environment that propagates metabolic disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1799652f66771ae76f0cbb049245c0e
http://www.sciencedirect.com/science/article/pii/S0022227520308609
http://www.sciencedirect.com/science/article/pii/S0022227520308609
Autor:
Michael L. McDaniel, Connie A. Marshall, Clay F. Semenkovich, Manu V. Chakravarthy, Trey Coleman, Kirk L. Pappan, Yimin Zhu, Mitchell B. Wice
Publikováno v:
Diabetes
OBJECTIVE—Low birth weight is associated with diabetes in adult life. Accelerated or “catch-up” postnatal growth in response to small birth size is thought to presage disease years later. Whether adult disease is caused by intrauterine β-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2570febb16b91871866cfca80e59b4c
https://doi.org/10.2337/db08-0404
https://doi.org/10.2337/db08-0404