Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michael L. J. Ashford"'
Autor:
Paul J. Meakin, Anna Mezzapesa, Eva Benabou, Mary E. Haas, Bernadette Bonardo, Michel Grino, Jean-Michel Brunel, Christèle Desbois-Mouthon, Sudha B. Biddinger, Roland Govers, Michael L. J. Ashford, Franck Peiretti
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent m
Externí odkaz:
https://doaj.org/article/527a3cb8a7ee44ba84d8fe3536cdc213
Autor:
Paul J Meakin, Vicky L Morrison, Claire C Sneddon, Terhi Savinko, Liisa Uotila, Susan M Jalicy, Jennie L Gabriel, Li Kang, Michael L J Ashford, Susanna C Fagerholm
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138872 (2015)
Beta2-integrins are important in leukocyte trafficking and function, and are regulated through the binding of cytoplasmic proteins, such as kindlin-3, to their intracellular domain. Here, we investigate the involvement of beta2-integrins in the regul
Externí odkaz:
https://doaj.org/article/a247e63f017248f79d5c40cb84987b44
Autor:
Julia M, Vlachaki Walker, Josephine L, Robb, Ana M, Cruz, Amrinder, Malhi, Paul G, Weightman Potter, Michael L J, Ashford, Rory J, McCrimmon, Kate L J, Ellacott, Craig, Beall
Publikováno v:
Diabetes, obesitymetabolism. 19(7)
To test the hypothesis that, given the role of AMP-activated protein kinase (AMPK) in regulating intracellular ATP levels, AMPK may alter ATP release from astrocytes, the main sources of extracellular ATP (eATP) within the brain.Measurements of ATP r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79a2a2af5cbdf0c7857b5154730d37af
https://pubmed.ncbi.nlm.nih.gov/28211632
https://pubmed.ncbi.nlm.nih.gov/28211632
Autor:
Elizabeth, Haythorne, D Lee, Hamilton, John A, Findlay, Craig, Beall, Rory J, McCrimmon, Michael L J, Ashford
Publikováno v:
Neuropharmacology. 111
Individuals with Type 1 diabetes (T1D) are often exposed to recurrent episodes of hypoglycaemia. This reduces hormonal and behavioural responses that normally counteract low glucose in order to maintain glucose homeostasis, with altered responsivenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5f20fb376a31cece1ab29f03cba1cdb
https://pubmed.ncbi.nlm.nih.gov/27618741
https://pubmed.ncbi.nlm.nih.gov/27618741
Autor:
Louise, Reilly, Jacqueline, Howie, Krzysztof, Wypijewski, Michael L J, Ashford, Donald W, Hilgemann, William, Fuller
Publikováno v:
The FASEB Journal
The electrogenic Na/Ca exchanger (NCX) mediates bidirectional Ca movements that are highly sensitive to changes of Na gradients in many cells. NCX1 is implicated in the pathogenesis of heart failure and a number of cardiac arrhythmias. We measured NC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ca64c29c5a936640fa090086e6ac519
https://pubmed.ncbi.nlm.nih.gov/26174834
https://pubmed.ncbi.nlm.nih.gov/26174834
Autor:
Krzysztof J, Wypijewski, Michele, Tinti, Wenzhang, Chen, Douglas, Lamont, Michael L J, Ashford, Sarah C, Calaghan, William, Fuller
Publikováno v:
Molecular & Cellular Proteomics : MCP
The lipid raft concept proposes that membrane environments enriched in cholesterol and sphingolipids cluster certain proteins and form platforms to integrate cell signaling. In cardiac muscle, caveolae concentrate signaling molecules and ion transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61c9ab4c65e79bbabe04d0ad808fef8d
https://pubmed.ncbi.nlm.nih.gov/25561500
https://pubmed.ncbi.nlm.nih.gov/25561500
Autor:
Paul J, Meakin, Sudhir, Chowdhry, Ritu S, Sharma, Fiona B, Ashford, Shaun V, Walsh, Rory J, McCrimmon, Albena T, Dinkova-Kostova, John F, Dillon, John D, Hayes, Michael L J, Ashford
Publikováno v:
Molecular and Cellular Biology
Mice lacking the transcription factor NF-E2 p45-related factor 2 (Nrf2) develop more severe nonalcoholic steatohepatitis (NASH), with cirrhosis, than wild-type (Nrf2(+/+)) mice when fed a high-fat (HF) diet for 24 weeks. Although NASH is usually asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d64756dc65c9535439ca62653e238545
https://pubmed.ncbi.nlm.nih.gov/24958099
https://pubmed.ncbi.nlm.nih.gov/24958099
Autor:
D Lee, Hamilton, John A, Findlay, Gemma, Montagut, Paul J, Meakin, Dawn, Bestow, Susan M, Jalicy, Michael L J, Ashford
Publikováno v:
Diabetologia
Aims/hypothesis Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe592de321ba93e4e6eb6f2f8a31d257
https://pubmed.ncbi.nlm.nih.gov/24849570
https://pubmed.ncbi.nlm.nih.gov/24849570
Autor:
Mark A, Smith, Kazunari, Hisadome, Hind, Al-Qassab, Helen, Heffron, Dominic J, Withers, Michael L J, Ashford
Publikováno v:
The Journal of physiology. 578(Pt 2)
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c891b356a84a236a29db5e973fc2ce21
https://pubmed.ncbi.nlm.nih.gov/17068101
https://pubmed.ncbi.nlm.nih.gov/17068101
Autor:
Craig Beall, Kaisa Piipari, Hind Al‑Qassab, Nadeene Parker, David Carling, Benoit Viollet, Dominic J. Withers, Michael L. J. Ashford
Publikováno v:
Biochemical Journal; Jun2010, Vol. 429 Issue 2, p323-333, 11p