Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Michael L. Heien"'
Autor:
Mitchell J. Bartlett, Lisa Y. So, Lajos Szabò, David P. Skinner, Kate L. Parent, Michael L. Heien, Todd W. Vanderah, Robin Polt, Scott J. Sherman, Torsten Falk
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)
Abstract Objectives Dopamine-replacement utilizing L-DOPA is still the mainstay treatment for Parkinson’s disease (PD), but often leads to development of L-DOPA-induced dyskinesia (LID), which can be as debilitating as the motor deficits. There is
Externí odkaz:
https://doaj.org/article/cc5db2cd57bf470db60b5ad5f7dc43f5
Autor:
Mitchell J. Bartlett, Omar S. Mabrouk, Lajos Szabò, Andrew J. Flores, Kate L. Parent, Jean M. Bidlack, Michael L. Heien, Robert T. Kennedy, Robin Polt, Scott J. Sherman, Torsten Falk
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 20 (2020)
In previous work we evaluated an opioid glycopeptide with mixed μ/δ-opioid receptor agonism that was a congener of leu-enkephalin, MMP-2200. The glycopeptide analogue showed penetration of the blood–brain barrier (BBB) after systemic administrati
Externí odkaz:
https://doaj.org/article/a3cc74abfdc2473e883739d4a7bac3a7
Autor:
Hoseok Choi, Hojin Shin, Hyun U. Cho, Charles D. Blaha, Michael L. Heien, Yoonbae Oh, Kendall H. Lee, Dong Pyo Jang
Publikováno v:
ACS Chemical Neuroscience. 13:2288-2297
Neurotransmitters, such as dopamine and serotonin, are responsible for mediating a wide array of neurologic functions, from memory to motivation. From measurements using fast scan cyclic voltammetry (FSCV), one of the main tools used to detect synapt
Autor:
Michael L. Heien, Blake T. Seaton
Publikováno v:
Anal Bioanal Chem
In vivo electrochemistry is a vital tool of neuroscience that allows for the detection, identification, and quantification of neurotransmitters, their metabolites, and other important analytes. One important goal of in vivo electrochemistry is a bett
Autor:
Daniel F. Hill, Zachary G. Olson, Mitchell J. Bartlett, Torsten Falk, Michael L. Heien, Stephen L. Cowen
Dopamine release in the ventral striatum is fundamental to adaptive appetitive behavior. Frustratingly, technological, and methodological hurdles have limited the investigation of the mechanisms that drive phasic dopamine release. Although dopamine n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f2f05e72e0d9b6eb4021139fc1f633
https://doi.org/10.1101/2022.07.31.502221
https://doi.org/10.1101/2022.07.31.502221
Autor:
Christopher R. Apostol, Kelsey Bernard, Parthasaradhireddy Tanguturi, Gabriella Molnar, Mitchell J. Bartlett, Lajos Szabò, Chenxi Liu, J. Bryce Ortiz, Maha Saber, Katherine R. Giordano, Tabitha R. F. Green, James Melvin, Helena W. Morrison, Lalitha Madhavan, Rachel K. Rowe, John M. Streicher, Michael L. Heien, Torsten Falk, Robin Polt
Publikováno v:
Frontiers in Drug Discovery. 1
There is an unmet clinical need for curative therapies to treat neurodegenerative disorders. Most mainstay treatments currently on the market only alleviate specific symptoms and do not reverse disease progression. The Pituitary adenylate cyclase-act
Autor:
Rohan Jha, J. Hudson Barnett, Kendall H. Lee, Yumin Kang, Aaron E. Rusheen, Sang Mun Hwang, Michael L. Heien, Charles D. Blaha, Abhinav Goyal, Cheonho Park, Hojin Shin, Dong Pyo Jang, Kevin E. Bennet, Yoonbae Oh, Jason Yuen, Hyun-U Cho
Publikováno v:
Anal Chem
Here, we present the development of a novel voltammetric technique, N-shaped multiple cyclic square wave voltammetry (N-MCSWV) and its application in vivo. It allows quantitative measurements of tonic extracellular levels of serotonin in vivo with mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcae182d57671d3c6be015e7b528c04e
https://europepmc.org/articles/PMC9393895/
https://europepmc.org/articles/PMC9393895/
Autor:
Breanna C. Gushiken, James R. Siegenthaler, Michael L. Heien, Daniel F. Hill, Stephen L. Cowen
Publikováno v:
ACS Sensors. 5:1890-1899
Carbon-fiber microelectrodes allow for high spatial and temporal measurements of electroactive neurotransmitter measurements in vivo using fast-scan cyclic voltammetry (FSCV). However, common instrumentation for such measurements systems lack patient
Publikováno v:
Anal Chem
Biofouling is a prevalent issue in studies that involve prolonged implantation of electrochemical probes in the brain. In long-term fast-scan cyclic voltammetry (FSCV) studies, biofouling manifests as a shift in the peak oxidative potential of the ba
Autor:
Michael L. Heien, Scott J. Sherman, Kate L. Parent, Robin Polt, David P Skinner, Lajos Szabo, Todd W. Vanderah, Lisa Y. So, Mitchell J. Bartlett, Torsten Falk
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)
BMC Research Notes
BMC Research Notes
Objectives Dopamine-replacement utilizing L-DOPA is still the mainstay treatment for Parkinson’s disease (PD), but often leads to development of L-DOPA-induced dyskinesia (LID), which can be as debilitating as the motor deficits. There is currently