Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael L. Denney"'
Autor:
Sau-Chi B. Yan, Michael L. Denney, Valentine J. Klimkowski, Amy J. Smith, Lea M. Johnson, Michael Enrico Richett, Minsheng Zhang, Jefferson Ray Mccowan, Kumiko Takeuchi, Todd J. Kohn, Nickolay Y. Chirgadze, Jolie Anne Bastian, Dianna L. Bailey, Donetta S. Gifford-Moore, Barbara G. Utterback, Gerald F. Smith, Daniel Jon Sall, David K. Clawson, Richard Waltz Harper, David W. Snyder, Stephen L. Briggs, Ho-Shen Lin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:775-780
Potent, subnanomolar thrombin inhibitors 4, 5, and 6 are developed through side chain optimization of novel, benzo[b]thiophene-based small organic entities 2 and 3 and through SAR additivity studies of the new structural elements identified. X-ray cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbe7d35a63ca810bf308f9e6a8bf352
https://doi.org/10.1016/s0960-894x(99)00074-8
https://doi.org/10.1016/s0960-894x(99)00074-8
Autor:
Jolie Anne Bastian, James H. Wikel, Donetta S. Gifford-Moore, Michael L. Denney, Nickolay Y. Chirgadze, Gerald F. Smith, Daniel Jon Sall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:363-368
The preparation and biological evaluation of a series of benzo[ b ]thiophene diamine thrombin inhibitors possessing conformationally restricted C-4″ linkers are reported. Compared to the parent compounds 1a/b , the unsaturated derivatives 3a/b exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16af0723892a3b6e63a4a5f34802325b
https://doi.org/10.1016/s0960-894x(98)00746-x
https://doi.org/10.1016/s0960-894x(98)00746-x
Publikováno v:
ChemInform. 24
The unsubstituted thieno[3,2-c]pyridine ring system was prepared from thiophene-3-carboxaldehyde in 4 steps. The sequence is suitable for scale-up.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a27a85df563bad4a139afc9f17f232a
https://doi.org/10.1002/chin.199338206
https://doi.org/10.1002/chin.199338206
Autor:
Todd J. Kohn, Jefferson Ray Mccowan, Kumiko Takeuchi, Smith Gf, Michael L. Denney, Donetta S. Gifford-Moore, Daniel Jon Sall
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ee54c1abcc81a50fde052ab190eaef8
https://doi.org/10.1002/chin.199926110
https://doi.org/10.1002/chin.199926110
Autor:
Marcia L. Kellam, William J. Coffman, Gerald F. Smith, Michael L. Denney, Daniel Jon Sall, Trelia J. Craft, Dennis R. Berry, Donetta S. Gifford-Moore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1025-1028
Methyl 3-(2-methyl-1-oxopropoxy)[1]benzothieno[3,2-b]furan-2-carboxylate (LY806303; 1) has been characterized as a novel, potent and selective inhibitor thrombin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5cdaf16bce1671d27fdb130370c3c45
https://doi.org/10.1016/s0960-894x(00)80611-3
https://doi.org/10.1016/s0960-894x(00)80611-3
Autor:
Gerald F. Smith, Matthew J. Fisher, John E. Toth, Nickolay Y. Chirgadze, Deborah D. Giera, Dianna L. Bailey, John A. Buben, Amy Clemens-Smith, Michael L. Denney, Michael Enrico Richett, Richard Waltz Harper, Jolie Anne Bastian, Alan David Palkowitz, Minsheng Zhang, Valentine J. Klimkowski, Todd J. Kohn, Jefferson Ray Mccowan, Kumiko Takeuchi, Ho-Shen Lin, Daniel Jon Sall, Donetta S. Gifford-Moore, Lea M. Johnson, David W. Snyder
Publikováno v:
Journal of medicinal chemistry. 43(4)
A systematic investigation of the structure-activity relationships of the C-3 side chain of the screening hit 1a led to the identification of the potent thrombin inhibitors 23c, 28c, and 31c. Their activities (1240, 903, and 1271 x 10(6) L/mol, respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b65bb93c4bac89d1ca25c10915de94
https://pubmed.ncbi.nlm.nih.gov/10691691
https://pubmed.ncbi.nlm.nih.gov/10691691
Autor:
Daniel Jon Sall, Todd J. Kohn, Donetta S. Gifford-Moore, Jefferson Ray Mccowan, Kumiko Takeuchi, Michael L. Denney, Smith Gf
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(5)
A novel series of benzo[b]thiophene diamine thrombin inhibitors with a conformationally restricted C3-side chain 3 was investigated. The constrained C3-side chain by a cyclohexyl ring contributed to not only an additive but also a synergistic effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb79b30e763ce347e11c5dfe9aea21f
https://pubmed.ncbi.nlm.nih.gov/10201843
https://pubmed.ncbi.nlm.nih.gov/10201843
Autor:
Nickolay Y. Chirgadze, Kenneth Lee Hauser, Ho-Shen Lin, Kenneth Jeff Thrasher, Stephen L. Briggs, Gerald F. Smith, Michael L. Denney, Sau-Chi B. Yan, Daniel Jon Sall, John A. Buben, K. Takeuchi, Donetta S. Gifford-Moore, Valentine J. Klimkowski, Jefferson Ray Mccowan, Barbara G. Utterback, David K. Clawson, Jolie Anne Bastian, Alan David Palkowitz, Minsheng Zhang, Richard Waltz Harper, Deborah D. Giera, Todd J. Kohn, Jennifer M. Tinsley
Publikováno v:
Journal of medicinal chemistry. 40(22)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e273868bb2a1580b5d2d0497e3331a9
https://pubmed.ncbi.nlm.nih.gov/9357512
https://pubmed.ncbi.nlm.nih.gov/9357512
Autor:
James H. Wikel, Ann E. Arfsten, Jefferson Ray Mccowan, Mark S. Smyth, Suzane L. Um, Robert Theodore Vasileff, Cathy S. Harms, Barbara G. Utterback, Michael L. Denney, Robert M. Scarborough, Virginia L. Wyss, Daniel Jon Sall, John Michael Morin, Jack W. Rose, Jolie Anne Bastian, Joseph A. Jakubowski
Publikováno v:
Journal of medicinal chemistry. 40(18)
The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa) antagonists is described. The additional conformational restriction offered by the bicyclic nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded371ee6341b52abe82497907ea5b5b
https://pubmed.ncbi.nlm.nih.gov/9288166
https://pubmed.ncbi.nlm.nih.gov/9288166
Publikováno v:
Journal of Heterocyclic Chemistry. 30:289-290
The unsubstituted thieno[3,2-c]pyridine ring system was prepared from thiophene-3-carboxaldehyde in 4 steps. The sequence is suitable for scale-up.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc967a6420e923f5eecaf8d28bf3e0c
https://doi.org/10.1002/jhet.5570300150
https://doi.org/10.1002/jhet.5570300150