Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Michael L. Curtin"'
Autor:
Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
Structures and PC3 viability IC50 data for compounds in Figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f450290df0d613596edbab94a5a07a69
https://doi.org/10.1158/1535-7163.22503433.v1
https://doi.org/10.1158/1535-7163.22503433.v1
Autor:
Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
Supplementary methods, tables S1-S3, and supplementary figures 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e7619544c11452e1775f6d92101867
https://doi.org/10.1158/1535-7163.22503430.v1
https://doi.org/10.1158/1535-7163.22503430.v1
Autor:
Kathy Sarris, Ying Wang, Gary G. Chiang, Yupeng He, Mikkel Algire, Ramzi F. Sweis, Huan-Qiu Li, Marina A. Pliushchev, Zhiqin Ji, Paul L. Richardson, Maricel Torrent, Bailin Shaw, Richard F. Clark, Michael L. Curtin, Justin D. Dietrich, Clarissa G. Jakob, Chaohong Sun, Sujatha Selvaraju, Haizhong Zhu, Hongyu Zhao, Michael R. Michaelides
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1576-1583
Herein we disclose SAR studies of a series of dimethylamino pyrrolidines which we recently reported as novel inhibitors of the PRC2 complex through disruption of EED/H3K27me3 binding. Modification of the indole and benzyl moieties of screening hit 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9b193e84408c501ad0a0b9d7c9b5bc
https://doi.org/10.1016/j.bmcl.2017.02.030
https://doi.org/10.1016/j.bmcl.2017.02.030
Autor:
Nirupama B. Soni, Anil Vasudevan, Jun Guo, Marina A. Pliushchev, Julie L. Wilsbacher, H. Robin Heyman, Michael R. Michaelides, Kathy Sarris, Bryan K. Sorensen, Richard F. Clark, Noah Tu, Min Cheng, George Doherty, Alla Korepanova, Anurupa Shrestha, Michael L. Curtin, Mikkel Algire, Badagnani Ilaria, Kenton L. Longenecker, Chris Tse, Diana Raich, Woller Kevin R, Robin R. Frey, Violeta L. Marin, Gary G. Chiang, T. Matthew Hansen, Ana L. Aguirre, F. Greg Buchanan, Peter Kovar, David Maag, Dong Cheng, Paul L. Richardson, Ramzi F. Sweis
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(15)
Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. Modification of the isoindoline and/or the terminal func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1bc793c61a6d664d259131a9672269
https://pubmed.ncbi.nlm.nih.gov/28610984
https://pubmed.ncbi.nlm.nih.gov/28610984
Autor:
Alla Korepanova, Danli L. Towne, F. Gregory Buchanan, Jun Guo, Stormy L. Koeniger, Diana Raich, Yan Shi, Michael L. Curtin, Gary G. Chiang, Bryan K. Sorensen, Yupeng He, Hua Tang, Vivek C. Abraham, H. Robin Heyman, Richard F. Clark, Kenton L. Longenecker, Saul H. Rosenberg, Paul L. Richardson, Badagnani Ilaria, Wenqing Gao, Julie L. Wilsbacher, Peter Kovar, David Maag, Samuel A.J. Trammell, Dong Cheng, T. Matthew Hansen, Shaun M. McLoughlin, Chris Tse, Min Cheng, Steven Cepa, Michael R. Michaelides, Sujatha Selvaraju, Charles Brenner
Publikováno v:
Molecular cancer therapeutics. 16(7)
Cancer cells are highly reliant on NAD+-dependent processes, including glucose metabolism, calcium signaling, DNA repair, and regulation of gene expression. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme for NAD+ salvage fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52767e3106bf204068387e3e1747ff90
https://pubmed.ncbi.nlm.nih.gov/28468779
https://pubmed.ncbi.nlm.nih.gov/28468779
Autor:
Kenneth M. Comess, Steven Kennedy, Donald J. Osterling, Michael L. Curtin, Masoud Vedadi, Ramzi F. Sweis, Guillermo Senisterra, Mikkel Algire, Evelyne Lima-Fernandes, Dalia Barsyte-Lovejoy, Justin D. Dietrich, William N. Pappano, Bailin Shaw, David Maag, Dong Cheng, Cheryl H. Arrowsmith, Fengling Li, Marina A. Pliushchev, Kelly L Klinge, Jun Guo, Chaohong Sun, Andrew M. Petros, Gary G. Chiang, Magdalena M. Szewczyk, Huan-Qiu Li, Maricel Torrent, Scott Galasinski, Sujatha Selvaraju, Yupeng He, David Lindley, Clarissa G. Jakob, Sanjay C. Panchal, Wenqing Gao, Lance J Bigelow, Haizhong Zhu, Fritz G. Buchanan, Qin Wu
Publikováno v:
Nature chemical biology. 13(4)
Polycomb repressive complex 2 (PRC2) is a regulator of epigenetic states required for development and homeostasis. PRC2 trimethylates histone H3 at lysine 27 (H3K27me3), which leads to gene silencing, and is dysregulated in many cancers. The embryoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df1801f71a6c72b86efbe30951bf648
https://pubmed.ncbi.nlm.nih.gov/28853738
https://pubmed.ncbi.nlm.nih.gov/28853738
Autor:
Patrick A. Marcotte, Jun Guo, Michael R. Michaelides, Steven K. Davidsen, David R. Reuter, Junling Li, Yanping Luo, Lori J. Pease, Chris Tse, Terrance J. Magoc, Ru-Qi Wei, Paul Tapang, Eric F. Johnson, Cherrie K. Donawho, Zehan Chen, Amanda M. Olson, Donald J. Osterling, Daniel H. Albert, Michael L. Curtin, Keith B. Glaser, Jennifer J. Bouska, Mai H. Bui, Robin R. Frey
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:617-627
ABT-348 [1-(4-(4-amino-7-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)phenyl)-3-(3-fluorophenyl)urea] is a novel ATP-competitive multitargeted kinase inhibitor with nanomolar potency (IC(50)) for inhibiting binding and cellular autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ff4def0b6e7aabec77986594da503f
https://doi.org/10.1124/jpet.112.197087
https://doi.org/10.1124/jpet.112.197087
Autor:
Melinda Yates, Lori J. Pease, Patrick A. Marcotte, Jennifer J. Bouska, Niru B. Soni, Daniel H. Albert, Robin R. Frey, Steven K. Davidsen, Michael L. Curtin, Keith B. Glaser, Michael R. Michaelides, Peter J. Dandliker, Asma A Ahmed, Paul Rafferty, Kent D. Stewart, Maria D Moskey, Candace Black-Schaefer, Peter F. Bousquet, H. Robin Heyman, George A. Cunha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1246-1249
A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0affa478acc38849cf981621ca7094cd
https://doi.org/10.1016/j.bmcl.2006.12.015
https://doi.org/10.1016/j.bmcl.2006.12.015
Autor:
Teresa Barlozzari, Shannon S Arries, Keith B. Glaser, Michael L. Curtin, Lori J. Pease, Patrick A. Marcotte, Robin R. Frey, Daniel H. Albert, Neil Wishart, George A. Cunha, Yan Guo, Jennifer J. Bouska, Lee D. Arnold, Jun Guo, Michael R. Michaelides, Kennan C. Marsh, Steven K. Davidsen, Joy Bauch, Asma A Ahmed, Peter F. Bousquet, Maria D Moskey, Paul Tapang, Kent D. Stewart, Yujia Dai, Zhiqin Ji, Vincent S. Stoll, Junling Li
Publikováno v:
Journal of Medicinal Chemistry. 48:6066-6083
A series of novel thienopyrimidine-based receptor tyrosine kinase inhibitors has been discovered. Investigation of structure-activity relationships at the 5- and 6-positions of the thienopyrimidine nucleus led to a series of N,N'-diaryl ureas that po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b70dc03317044f34818ffeb418063c2
https://doi.org/10.1021/jm050458h
https://doi.org/10.1021/jm050458h
Autor:
Michael L. Curtin, Keith B. Glaser
Publikováno v:
Current Medicinal Chemistry. 10:2373-2392
Histone deacetylase inhibitors have generated significant interest as anti-cancer agents due to their ability to cause growth arrest, terminal differentiation and/ or apoptosis in carcinoma cells. Abbott entered this area after the serendipitous disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18ad286d833a0bbd0707f949a3c63f2
https://doi.org/10.2174/0929867033456576
https://doi.org/10.2174/0929867033456576