Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Michael L. Cunningham"'
Autor:
Anthony M. Musolf, Cristina M. Justice, Zeynep Erdogan-Yildirim, Seppe Goovaerts, Araceli Cuellar, John R. Shaffer, Mary L. Marazita, Peter Claes, Seth M. Weinberg, Jae Li, Craig Senders, Marike Zwienenberg, Emil Simeonov, Radka Kaneva, Tony Roscioli, Lorena Di Pietro, Marta Barba, Wanda Lattanzi, Michael L. Cunningham, Paul A. Romitti, Simeon A. Boyadjiev
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Craniosynostosis (CS) is a major birth defect resulting from premature fusion of cranial sutures. Nonsyndromic CS occurs more frequently than syndromic CS, with sagittal nonsyndromic craniosynostosis (sNCS) presenting as the most common CS p
Externí odkaz:
https://doaj.org/article/f648374bc2b0416ab9f8c6846eee6350
Autor:
Andrew T. Timberlake, MD, PhD, Daniel Quiat, MD, Michael L. Cunningham, MD, PhD, John Persing, MD, Daniela Luquetti, MD PhD, Carrie L. Heike, MD, Jonathan Seidman, PhD, Christine Seidman, PhD
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 11, Iss 4S, Pp 37-38 (2023)
Externí odkaz:
https://doaj.org/article/d436710092004aa48d6bad1045ee0a07
Autor:
Andrew T. Timberlake, Casey Griffin, Carrie L. Heike, Anne V. Hing, Michael L. Cunningham, David Chitayat, Mark R. Davis, Soghra J. Doust, Amelia F. Drake, Milagros M. Duenas-Roque, Jack Goldblatt, Jonas A. Gustafson, Paula Hurtado-Villa, Alexis Johns, Natalya Karp, Nigel G. Laing, Leanne Magee, University of Washington Center for Mendelian Genomics, Sureni V. Mullegama, Harry Pachajoa, Gloria L. Porras-Hurtado, Rhonda E. Schnur, Jennie Slee, Steven L. Singer, David A. Staffenberg, Andrew E. Timms, Cheryl A. Wise, Ignacio Zarante, Jean-Pierre Saint-Jeannet, Daniela V. Luquetti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Despite being a common congenital facial anomaly, the genetic etiology of craniofacial microsomia (CFM) is not well understood. Here, the authors use exome and genome sequencing of 146 individuals with CFM to identify haploinsufficient variants in SF
Externí odkaz:
https://doaj.org/article/d765e285eeb1444f96c9860e6bc243dd
Autor:
Samantha Lapehn, Jonas A. Gustafson, Andrew E. Timms, Michael L. Cunningham, Alison G. Paquette
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5353 (2023)
Craniosynostosis is a birth defect where calvarial sutures close prematurely, as part of a genetic syndrome or independently, with unknown cause. This study aimed to identify differences in gene expression in primary calvarial cell lines derived from
Externí odkaz:
https://doaj.org/article/e3770efabc9440d5a53dcb90b4f2884d
Autor:
Stanley M. Kanai, Caleb Heffner, Timothy C. Cox, Michael L. Cunningham, Francisco A. Perez, Aaron M. Bauer, Philip Reigan, Cristan Carter, Stephen A. Murray, David E. Clouthier
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Auriculocondylar syndrome 2 (ARCND2) is a rare autosomal dominant craniofacial malformation syndrome linked to multiple genetic variants in the coding sequence of phospholipase C β4 (PLCB4). PLCB4 is a direct signaling effector of the endothelin rec
Externí odkaz:
https://doaj.org/article/1018cf0b961340698266dbc93ce8cfff
Publikováno v:
Case Reports in Genetics, Vol 2022 (2022)
Craniosynostosis, the premature fusion of the calvarial bones, has numerous etiologies. Among them, several involve mutations in genes related to the TGFb signaling pathway, a critical molecular mediator of human development. These TGFb pathway-assoc
Externí odkaz:
https://doaj.org/article/d5aaa8b618f342bcaf2d01ac4e626ada
Autor:
Michael L. Cunningham, Bradley J. Collins, Milton R. Hejtmancik, Ronald A. Herbert, Gregory S. Travlos, Molly K. Vallant, Matthew D. Stout
Publikováno v:
PPAR Research, Vol 2010 (2010)
Gemfibrozil is a widely prescribed hypolipidemic agent in humans and a peroxisome proliferator and liver carcinogen in rats. Three-month feed studies of gemfibrozil were conducted by the National Toxicology Program (NTP) in male Harlan Sprague-Dawley
Externí odkaz:
https://doaj.org/article/6efe2e402c234e0883a3bfab29e0c38e
Publikováno v:
PPAR Research, Vol 2010 (2010)
Externí odkaz:
https://doaj.org/article/b8868de0852040589bbfa5b2eeaf81df
Autor:
Mostafa Z. Badr, Alexander Shnyra, Mikhail Zoubine, Maxim Norkin, Betty Herndon, Tim Quinn, Roberto N. Miranda, Michael L. Cunningham, Agostino Molteni
Publikováno v:
PPAR Research, Vol 2007 (2007)
Infection with Mycobacterium tuberculosis (TB) induces pulmonary immunopathology mediated by classical Th1 type of acquired immunity with hepatic involvement in up to 80% of disseminated cases. Since PPAR agonists cause immune responses characterized
Externí odkaz:
https://doaj.org/article/3328e255bd34497b80782c0ea16ec52e
Autor:
Zahra A. Aldawood, Luigi Mancinelli, Xuehui Geng, Shu-Chi A. Yeh, Roberta Di Carlo, Taiana C. Leite, Jonas Gustafson, Katarzyna Wilk, Joseph Yozgatian, Sasan Garakani, Seyed Hossein Bassir, Michael L. Cunningham, Charles P. Lin, Giuseppe Intini
Publikováno v:
Proceedings of the National Academy of Sciences. 120
In newborn humans, and up to approximately 2 y of age, calvarial bone defects can naturally regenerate. This remarkable regeneration potential is also found in newborn mice and is absent in adult mice. Since previous studies showed that the mouse cal